ID G0RU71_HYPJQ Unreviewed; 483 AA.
AC G0RU71;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 28-JAN-2026, entry version 47.
DE SubName: Full=Sphingosine kinase {ECO:0000313|EMBL:EGR45335.1};
GN ORFNames=TRIREDRAFT_68412 {ECO:0000313|EMBL:EGR45335.1};
OS Hypocrea jecorina (strain QM6a) (Trichoderma reesei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=431241 {ECO:0000313|Proteomes:UP000008984};
RN [1] {ECO:0000313|EMBL:EGR45335.1, ECO:0000313|Proteomes:UP000008984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QM6a {ECO:0000313|EMBL:EGR45335.1,
RC ECO:0000313|Proteomes:UP000008984};
RX PubMed=18454138; DOI=10.1038/nbt1403;
RA Martinez D., Berka R.M., Henrissat B., Saloheimo M., Arvas M., Baker S.E.,
RA Chapman J., Chertkov O., Coutinho P.M., Cullen D., Danchin E.G.,
RA Grigoriev I.V., Harris P., Jackson M., Kubicek C.P., Han C.S., Ho I.,
RA Larrondo L.F., de Leon A.L., Magnuson J.K., Merino S., Misra M., Nelson B.,
RA Putnam N., Robbertse B., Salamov A.A., Schmoll M., Terry A., Thayer N.,
RA Westerholm-Parvinen A., Schoch C.L., Yao J., Barabote R., Nelson M.A.,
RA Detter C., Bruce D., Kuske C.R., Xie G., Richardson P., Rokhsar D.S.,
RA Lucas S.M., Rubin E.M., Dunn-Coleman N., Ward M., Brettin T.S.;
RT "Genome sequencing and analysis of the biomass-degrading fungus Trichoderma
RT reesei (syn. Hypocrea jecorina).";
RL Nat. Biotechnol. 26:553-560(2008).
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DR EMBL; GL985080; EGR45335.1; -; Genomic_DNA.
DR RefSeq; XP_006968777.1; XM_006968715.1.
DR AlphaFoldDB; G0RU71; -.
DR STRING; 431241.G0RU71; -.
DR GeneID; 18487704; -.
DR KEGG; tre:TRIREDRAFT_68412; -.
DR VEuPathDB; FungiDB:TRIREDRAFT_68412; -.
DR eggNOG; KOG1116; Eukaryota.
DR HOGENOM; CLU_013399_0_1_1; -.
DR OrthoDB; 3853857at2759; -.
DR Proteomes; UP000008984; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0016020; C:membrane; IEA:TreeGrafter.
DR GO; GO:0001727; F:lipid kinase activity; IEA:TreeGrafter.
DR GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:UniProtKB-ARBA.
DR GO; GO:0046512; P:sphingosine biosynthetic process; IEA:TreeGrafter.
DR Gene3D; 2.60.200.40; -; 1.
DR Gene3D; 3.40.50.10330; Probable inorganic polyphosphate/atp-NAD kinase, domain 1; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR055916; DUF7493.
DR InterPro; IPR050187; Lipid_Phosphate_FormReg.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR PANTHER; PTHR12358:SF31; ACYLGLYCEROL KINASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR Pfam; PF24321; DUF7493; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:EGR45335.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008984};
KW Transferase {ECO:0000313|EMBL:EGR45335.1}.
FT DOMAIN 111..250
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..20
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 483 AA; 52622 MW; FB945728E6DF0171 CRC64;
MILLTDPDGK SRKKAAKGKA GKQPSEDISC FGCLPWQAAD GKGKHTIPLY NVLWAEVRDN
ALVVDYAAPR KSSLKLQQWT FALPTPELET GDPSPEAFVA ALIAAAYGEA KPRKRAYVLI
NPHSGPGGAL GKWKKHVKPF FEAARMELDV VTLSRGGEAT ELSEKVDIER FDTIMALSGD
GTPYEIFNGL GKRPDAAKAL AKIAVSHIPC GSGNAFSLNC NGSNDAGVSA LAVVKGVVMP
LDLVSITQGD RRVLSFLSQS LGIIAESDLG TENMRWMGNK RFEIGLATRV LKKKCYPFDL
SVKVEVDGKE MIKQHYKKHV EDHSLLSVDA VTDGAEGLPQ LKYGTVQDEV PADWETQSYD
NIGTFYVGNM AYMSPDANFF SAALPTDGLM DLVMMPANIS PMAVTKALLS VETGKFFDNP
IVSYKKISAY RITPRNQQDG YISIDGERIP FEPFQAEIHR GLGRVISKRG LYEAEGPTGW
KEA
//
