ID G2LEF0_CHLTF Unreviewed; 629 AA.
AC G2LEF0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 28-JAN-2026, entry version 75.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN OrderedLocusNames=Cabther_A0856 {ECO:0000313|EMBL:AEP11613.1};
OS Chloracidobacterium thermophilum (strain B).
OC Bacteria; Pseudomonadati; Acidobacteriota; Terriglobia; Terriglobales;
OC Acidobacteriaceae; Chloracidobacterium.
OX NCBI_TaxID=981222 {ECO:0000313|EMBL:AEP11613.1, ECO:0000313|Proteomes:UP000006791};
RN [1] {ECO:0000313|EMBL:AEP11613.1, ECO:0000313|Proteomes:UP000006791}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B {ECO:0000313|EMBL:AEP11613.1,
RC ECO:0000313|Proteomes:UP000006791};
RX PubMed=21951563; DOI=10.1111/j.1462-2920.2011.02592.x;
RA Garcia Costas A.M., Liu Z., Tomsho L.P., Schuster S.C., Ward D.M.,
RA Bryant D.A.;
RT "Complete genome of Candidatus Chloracidobacterium thermophilum, a
RT chlorophyll-based photoheterotroph belonging to the phylum Acidobacteria.";
RL Environ. Microbiol. 14:177-190(2012).
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CP002514; AEP11613.1; -; Genomic_DNA.
DR RefSeq; WP_014099351.1; NC_016024.1.
DR AlphaFoldDB; G2LEF0; -.
DR STRING; 981222.Cabther_A0856; -.
DR KEGG; ctm:Cabther_A0856; -.
DR HOGENOM; CLU_023030_3_0_0; -.
DR OrthoDB; 9804504at2; -.
DR Proteomes; UP000006791; Chromosome 1.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:AEP11613.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000006791}.
FT DOMAIN 2..174
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 629 AA; 69110 MW; 7177C4CF10397F37 CRC64;
MERSVIIGTA GHIDHGKTSL VQALTGTNPD RLPEEQRRGM TIDLGFAHLN YRDWRFAFVD
VPGHERFIKN MLAGAHGIDL VLLVIAADEG VMPQTVEHLS ICQLLGLSHG VIALTKCDLV
EPDWLALIRD DVARFTQGTF LAGKPVVAVS AHTGAGCEAL LQALAGEAAA VRPHAVACPP
RLPIDRIFTR PGFGTVVTGT LISGTFAVGE EVSIEPGGIV TRIRGLEVHG VARKEVHAGE
RVALNLTSLE VGDLRRGDVV TPLHRFHPTS RLDVQLELLA DAPGPLTDNT RVRLHHGTSE
VMARVTLLDG RHELPPGNVC FAQLRLEAPL LALPDDRFIL RRYSPATTIG GGKILDVHPP
RRRGRSRQTD DVLKQLAAGG DQRRMAFVRR TGATGLTLAE LASLTGDSDA ELEAFARRTP
ECVFLGPARR LVAQTALDQL CQNITTTLET LHRERPRQPD LPREEIRQRT AHNLPTEVFQ
HAVTRLVHEQ RIVADAHAMR LASHQVQLSA SDTAQKQTVE QLCRQAGWHM PTLPDLCRLT
NRPATQVLAD VQLLIIEGRL VRVGDFFLHA EAASELLARL RQAKTKGETL DVGAFKVLFD
LPRKYAIPLL EWLDQTGVTR RYGNIRLMA
//
