ID G3P2B5_GASAC Unreviewed; 480 AA.
AC G3P2B5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 27-NOV-2024, sequence version 2.
DT 10-JUN-2026, entry version 61.
DE RecName: Full=Centrosomal protein 57kDa-like protein 1 {ECO:0000256|ARBA:ARBA00041218};
DE AltName: Full=Cep57-related protein {ECO:0000256|ARBA:ARBA00042578};
OS Gasterosteus aculeatus aculeatus (three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=481459 {ECO:0000313|Ensembl:ENSGACP00000011738.2, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000011738.2, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lake Benthic {ECO:0000313|Ensembl:ENSGACP00000011738.2,
RC ECO:0000313|Proteomes:UP000007635};
RX PubMed=33598708;
RA Nath S., Shaw D.E., White M.A.;
RT "Improved contiguity of the threespine stickleback genome using long-read
RT sequencing.";
RL G3 (Bethesda) 11:0-0(2021).
RN [2] {ECO:0000313|Ensembl:ENSGACP00000011738.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JAN-2026) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC -!- SIMILARITY: Belongs to the translokin family.
CC {ECO:0000256|ARBA:ARBA00008179}.
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DR RefSeq; XP_040017335.1; XM_040161401.1.
DR AlphaFoldDB; G3P2B5; -.
DR STRING; 69293.ENSGACP00000011738; -.
DR Ensembl; ENSGACT00000011762.2; ENSGACP00000011738.2; ENSGACG00000008882.2.
DR KEGG; gat:120808457; -.
DR CTD; 285753; -.
DR eggNOG; ENOG502QTVF; Eukaryota.
DR GeneTree; ENSGT00530000063695; -.
DR InParanoid; G3P2B5; -.
DR OMA; METYHDQ; -.
DR Proteomes; UP000007635; Chromosome XVIII.
DR Bgee; ENSGACG00000008882; Expressed in head kidney and 12 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR Gene3D; 1.20.58.90; -; 1.
DR InterPro; IPR051756; Centrosomal_MT-associated.
DR InterPro; IPR025913; Cep57_CLD.
DR InterPro; IPR024957; Cep57_MT-bd_dom.
DR PANTHER; PTHR19336:SF10; CENTROSOMAL PROTEIN CEP57L1; 1.
DR PANTHER; PTHR19336; UNCHARACTERIZED DUF1167; 1.
DR Pfam; PF14073; Cep57_CLD; 1.
DR Pfam; PF06657; Cep57_MT_bd; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 59..237
FT /note="Cep57 centrosome localisation"
FT /evidence="ECO:0000259|Pfam:PF14073"
FT DOMAIN 347..414
FT /note="Cep57 centrosome microtubule-binding"
FT /evidence="ECO:0000259|Pfam:PF06657"
FT REGION 35..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 57..91
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 203..230
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 40..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..259
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 480 AA; 54327 MW; AB5288768E4035BB CRC64;
METYHDQIFD SPSKNSYIGS YYQPPNRIVP TARQLEFPGR SSNSTDPQMT TKPKIDSTAV
VDALKTLQEK IRRLELERKQ AQKSYGQFSQ DAWRRPEVTG SLAVHSQAVA GQPATGNSGK
KELDSKMQSA ETRCKVLEKQ LDYMRKMVES AKKERNVLME NQASLQNQQP CSSNTQCQRD
KLEKLESECL KLSQTQTLAE TKLAILEQKL LKEEHERKIV QEKADQLQRE LEINFQLSVP
TADEIKPKKK TPKNPKKTSR QTELPSPRGP RHKIMPFVAG TSTSPSHSVH ANVQSILHMM
KHHQPQLCER VSTLHRSGCG AKKSLQRDFV SSSTTSPETD GDPIQAEHPL GSLSELLLAL
QDELGQMSFE HQELVHQIES TQHCKQKPDL QRELESLIAR MEEKGAQITK LRKHQQKVHK
LCAEEHAAKT SGAIRPPVPS PVKAKSKRTK GGANHNNLQL LRDTQKFRNS LKQDDLSWET
//
