ID   G3T352_LOXAF            Unreviewed;       730 AA.
AC   G3T352;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   10-JUN-2026, entry version 59.
DE   SubName: Full=Progesterone immunomodulatory binding factor 1 {ECO:0000313|Ensembl:ENSLAFP00000007647.3};
GN   Name=PIBF1 {ECO:0000313|Ensembl:ENSLAFP00000007647.3};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000007647.3, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000007647.3}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000007647.3};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000007647.3}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000007647.3};
RG   Ensembl;
RL   Submitted (JAN-2026) to UniProtKB.
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DR   AlphaFoldDB; G3T352; -.
DR   FunCoup; G3T352; 368.
DR   STRING; 9785.ENSLAFP00000007647; -.
DR   Ensembl; ENSLAFT00000009121.3; ENSLAFP00000007647.3; ENSLAFG00000009121.3.
DR   eggNOG; ENOG502QRKC; Eukaryota.
DR   GeneTree; ENSGT00390000015293; -.
DR   HOGENOM; CLU_014616_0_0_1; -.
DR   InParanoid; G3T352; -.
DR   OMA; KCERDTF; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0005136; F:interleukin-4 receptor binding; IEA:Ensembl.
DR   GO; GO:0007080; P:mitotic metaphase chromosome alignment; IEA:Ensembl.
DR   GO; GO:0090307; P:mitotic spindle assembly; IEA:Ensembl.
DR   GO; GO:0032695; P:negative regulation of interleukin-12 production; IEA:Ensembl.
DR   GO; GO:0032815; P:negative regulation of natural killer cell activation; IEA:Ensembl.
DR   GO; GO:0031393; P:negative regulation of prostaglandin biosynthetic process; IEA:Ensembl.
DR   GO; GO:1905515; P:non-motile cilium assembly; IEA:Ensembl.
DR   GO; GO:0032733; P:positive regulation of interleukin-10 production; IEA:Ensembl.
DR   GO; GO:0071539; P:protein localization to centrosome; IEA:Ensembl.
DR   InterPro; IPR026205; PIBF1.
DR   PANTHER; PTHR18950; PROGESTERONE-INDUCED BLOCKING FACTOR 1; 1.
DR   PANTHER; PTHR18950:SF1; PROGESTERONE-INDUCED-BLOCKING FACTOR 1; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          703..730
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          78..155
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          205..430
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          474..550
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          595..667
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..11
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        707..730
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   730 AA;  86511 MW;  371061C85573E4E4 CRC64;
     MSRKIPKESK KVNVSSSLES EDISLETTVP TDDVSSSEER DGKIKITRQL IERKELLHNI
     QLLKIELSQK NMMIDNLKMD YLTKIEELEE KLNDALHQKQ LLTLRLDNQL SFQQKDARKY
     QELLKQEMET ILLRQKQLEE TNLQLREKAG DIRRNLRDFE LAEEQYMKLK AFPEDQLSIP
     EYVSIRFYEL VTPLRKEICE LQVKKNDLSE ELSANKGQLK QLMEVRMEER RSCSELQNRC
     QRLALELADT KQLIQQGDYR QENYDKVKSE RDALEQEATE FRRKHEILEA SLKTQVKERS
     ELSKEVATLQ QTITLLQKDK EYLNRQNMEL SVRCAHEEDR LERLQAQLEE TKKSREEMYE
     KYVTSRDHYK TEYENKLRDE LEQIRLKTNQ EIDQLRSASR EMYERENRNL REARDNAVAE
     KDRAVMAEKD ALEKHDQLLD RYRELQLSEE SKVTEFLHQS KLKSFECERV QLLQEETARN
     LTQCQLECEK YQKKLEVLTK EFYSLQASSE KRITELQAQN SEHQARLDIY EKLEKELDEI
     IMQTAEIENE DEAERILFSY GYGANVPTTA KRRLKQSVHL ARRVLQLEKQ NSLILKDLEH
     QKDQVTQLSQ ELDRANSLLN QAQQPYRYLI ESVRQRDSKI DSLKGCVAQL EKDVSNLNKE
     KSALLQMKNQ MALDLEQLLN HREELAAMKQ ILINMRSKPH EGSLLLTKKD SKTVTENQKS
     ETLDVPREHD
//