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Database: UniProt
Entry: G3XCK4
LinkDB: G3XCK4
Original site: G3XCK4 
ID   G3XCK4_PSEAI            Unreviewed;       293 AA.
AC   G3XCK4; A0A1S1C5A7;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   07-APR-2021, entry version 75.
DE   RecName: Full=Glucose-1-phosphate thymidylyltransferase {ECO:0000256|ARBA:ARBA00012461, ECO:0000256|RuleBase:RU003706};
DE            EC=2.7.7.24 {ECO:0000256|ARBA:ARBA00012461, ECO:0000256|RuleBase:RU003706};
GN   Name=rmlA {ECO:0000313|EMBL:CAC82197.1};
GN   Synonyms=rfbA {ECO:0000313|EMBL:RPM18169.1}, rmlA1
GN   {ECO:0000313|EMBL:VFT43480.1};
GN   ORFNames=CAZ10_00575 {ECO:0000313|EMBL:OTI65806.1}, E4V10_15605
GN   {ECO:0000313|EMBL:TGA88496.1}, IPC1295_11285
GN   {ECO:0000313|EMBL:RPM18169.1}, IPC1323_07775
GN   {ECO:0000313|EMBL:TEH37742.1}, IPC1481_07225
GN   {ECO:0000313|EMBL:TEF46654.1}, IPC1505_02770
GN   {ECO:0000313|EMBL:TEE28760.1}, IPC1509_10375
GN   {ECO:0000313|EMBL:TEE27462.1}, IPC620_02790
GN   {ECO:0000313|EMBL:TEJ27108.1}, NCTC13621_05427
GN   {ECO:0000313|EMBL:VFT43480.1}, PAMH19_2921
GN   {ECO:0000313|EMBL:CEI13536.1};
OS   Pseudomonas aeruginosa.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=287 {ECO:0000313|EMBL:CAC82197.1};
RN   [1] {ECO:0000313|EMBL:CAC82197.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PA01 {ECO:0000313|EMBL:CAC82197.1};
RA   Maeki M.;
RT   "Cloning and characterization of the rmlA gene of Pseudomonas aeruginosa.";
RL   Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CEI13536.1, ECO:0000313|Proteomes:UP000043988}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MH19 {ECO:0000313|EMBL:CEI13536.1,
RC   ECO:0000313|Proteomes:UP000043988};
RA   Wibberg Daniel;
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:OTI65806.1, ECO:0000313|Proteomes:UP000194857}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S567_C10_BS {ECO:0000313|EMBL:OTI65806.1,
RC   ECO:0000313|Proteomes:UP000194857};
RA   Song R., Chenine A.L., Ruprecht R.M.;
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:RPM18169.1, ECO:0000313|Proteomes:UP000284767}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PA-W36 {ECO:0000313|EMBL:RPM18169.1,
RC   ECO:0000313|Proteomes:UP000284767};
RA   Feschi L., Jeukens J., Emond-Rheault J.-G., Kukavica-Ibrulj I., Boyle B.,
RA   Levesque R.C.;
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|Proteomes:UP000297232, ECO:0000313|Proteomes:UP000297361, ECO:0000313|Proteomes:UP000297499}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=110238627 {ECO:0000313|EMBL:TEE27462.1,
RC   ECO:0000313|Proteomes:UP000297232}, 4094345258
RC   {ECO:0000313|EMBL:TEF46654.1, ECO:0000313|Proteomes:UP000297560},
RC   5024382749-13 {ECO:0000313|EMBL:TEE28760.1,
RC   ECO:0000313|Proteomes:UP000298413}, 5999.2
RC   {ECO:0000313|EMBL:TEH37742.1, ECO:0000313|Proteomes:UP000297361}, and
RC   PA-CL524 {ECO:0000313|EMBL:TEJ27108.1,
RC   ECO:0000313|Proteomes:UP000297499};
RA   Jeukens J., Luca F., Kukavica-Ibrulj I., Emond-Rheault J.-G., Allard C.,
RA   Barbeau J., Cantin A., Charette S.J., Deziel E., Malouin F., Milot J.,
RA   Nguyen D., Popa C., Boyle B., Levesque R.C.;
RT   "The Pseudomonas aeruginosa population among Cystic Fibrosis patients in
RT   Quebec, Canada: a hotspot in CF with no epidemic isolates.";
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:RPM18169.1, ECO:0000313|Proteomes:UP000284767}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PA-W36 {ECO:0000313|EMBL:RPM18169.1,
RC   ECO:0000313|Proteomes:UP000284767};
RA   Freschi L., Vincent A.T., Jeukens J., Emond-Rheault J.-G.,
RA   Kukavica-Ibrulj I., Dupont M.-J., Charette S.J., Boyle B., Levesque R.C.;
RT   "The Pseudomonas aeruginosa pan-genome provides new insights on its
RT   population structure, horizontal gene transfer and pathogenicity.";
RL   Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:TGA88496.1, ECO:0000313|Proteomes:UP000297845}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F815101 {ECO:0000313|EMBL:TGA88496.1,
RC   ECO:0000313|Proteomes:UP000297845};
RA   Corey B., Hoang L., Ferris D., Wang B., Wilber A., Krajden M., Kwak Y.,
RA   Mcgann P., Jones A.;
RT   "BCCDC submission to MRSN (WRAIR), pending publication.";
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:VFT43480.1, ECO:0000313|Proteomes:UP000344659}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC13621 {ECO:0000313|EMBL:VFT43480.1,
RC   ECO:0000313|Proteomes:UP000344659};
RG   Pathogen Informatics;
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the formation of dTDP-glucose, from dTTP and
CC       glucose 1-phosphate, as well as its pyrophosphorolysis.
CC       {ECO:0000256|RuleBase:RU003706}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate +
CC         dTDP-alpha-D-glucose; Xref=Rhea:RHEA:15225, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37568, ChEBI:CHEBI:57477,
CC         ChEBI:CHEBI:58601; EC=2.7.7.24;
CC         Evidence={ECO:0000256|ARBA:ARBA00001095,
CC         ECO:0000256|RuleBase:RU003706};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SIMILARITY: Belongs to the glucose-1-phosphate thymidylyltransferase
CC       family. {ECO:0000256|ARBA:ARBA00010480, ECO:0000256|RuleBase:RU003706}.
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DR   EMBL; AJ298592; CAC82197.1; -; Genomic_DNA.
DR   EMBL; CDAZ01000009; CEI13536.1; -; Genomic_DNA.
DR   EMBL; NFFZ01000001; OTI65806.1; -; Genomic_DNA.
DR   EMBL; NSNE01000005; RPM18169.1; -; Genomic_DNA.
DR   EMBL; RWMJ01000003; TEE27462.1; -; Genomic_DNA.
DR   EMBL; RWMN01000001; TEE28760.1; -; Genomic_DNA.
DR   EMBL; RWNG01000004; TEF46654.1; -; Genomic_DNA.
DR   EMBL; RWOM01000002; TEH37742.1; -; Genomic_DNA.
DR   EMBL; RWPP01000001; TEJ27108.1; -; Genomic_DNA.
DR   EMBL; SRHR01000021; TGA88496.1; -; Genomic_DNA.
DR   EMBL; CAADJP010000010; VFT43480.1; -; Genomic_DNA.
DR   RefSeq; WP_003105518.1; NZ_WXZT01000015.1.
DR   STRING; 287.DR97_2531; -.
DR   EnsemblBacteria; CEI13536; CEI13536; PAMH19_2921.
DR   EnsemblBacteria; OTI65806; OTI65806; CAZ10_00575.
DR   PATRIC; fig|287.1479.peg.4101; -.
DR   eggNOG; COG1209; Bacteria.
DR   OrthoDB; 1004719at2; -.
DR   Proteomes; UP000043988; Unassembled WGS sequence.
DR   Proteomes; UP000194857; Unassembled WGS sequence.
DR   Proteomes; UP000284767; Unassembled WGS sequence.
DR   Proteomes; UP000297232; Unassembled WGS sequence.
DR   Proteomes; UP000297361; Unassembled WGS sequence.
DR   Proteomes; UP000297499; Unassembled WGS sequence.
DR   Proteomes; UP000297560; Unassembled WGS sequence.
DR   Proteomes; UP000297845; Unassembled WGS sequence.
DR   Proteomes; UP000298413; Unassembled WGS sequence.
DR   Proteomes; UP000344659; Unassembled WGS sequence.
DR   GO; GO:0008879; F:glucose-1-phosphate thymidylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR   CDD; cd02538; G1P_TT_short; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR005907; G1P_thy_trans_s.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR43532; PTHR43532; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   TIGRFAMs; TIGR01207; rmlA; 1.
PE   3: Inferred from homology;
KW   Magnesium {ECO:0000256|RuleBase:RU003706};
KW   Metal-binding {ECO:0000256|RuleBase:RU003706};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU003706,
KW   ECO:0000313|EMBL:CEI13536.1};
KW   Transferase {ECO:0000256|RuleBase:RU003706, ECO:0000313|EMBL:CAC82197.1}.
FT   DOMAIN          4..240
FT                   /note="NTP_transferase"
FT                   /evidence="ECO:0000259|Pfam:PF00483"
SQ   SEQUENCE   293 AA;  32457 MW;  1E249F4359DC0553 CRC64;
     MKRKGIILAG GSGTRLHPAT LAISKQLLPV YDKPMIYYPL STLMLAGIRE ILIISTPQDT
     PRFQQLLGDG SNWGLDLQYA VQPSPDGLAQ AFLIGESFIG NDLSALVLGD NLYYGHDFHE
     LLGSASQRQT GASVFAYHVL DPERYGVVEF DQGGKAISLE EKPLEPKSNY AVTGLYFYDQ
     QVVDIARDLK PSPRGELEIT DVNRAYLERG QLSVEIMGRG YAWLDTGTHD SLLEAGQFIA
     TLENRQGLKV ACPEEIAYRQ KWIDAAQLEK LAAPLAKNGY GQYLKRLLTE TVY
//
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