ID G7QD14_9BACT Unreviewed; 639 AA.
AC G7QD14;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 28-JAN-2026, entry version 69.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=DFW101_0303 {ECO:0000313|EMBL:EHJ46320.1};
OS Solidesulfovibrio carbinoliphilus subsp. oakridgensis.
OC Bacteria; Pseudomonadati; Thermodesulfobacteriota; Desulfovibrionia;
OC Desulfovibrionales; Desulfovibrionaceae; Solidesulfovibrio.
OX NCBI_TaxID=694327 {ECO:0000313|EMBL:EHJ46320.1, ECO:0000313|Proteomes:UP000004662};
RN [1] {ECO:0000313|Proteomes:UP000004662}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FW-101-2B {ECO:0000313|Proteomes:UP000004662};
RX PubMed=25767232;
RA Ramsay B.D., Hwang C., Woo H.L., Carroll S.L., Lucas S., Han J.,
RA Lapidus A.L., Cheng J.F., Goodwin L.A., Pitluck S., Peters L., Chertkov O.,
RA Held B., Detter J.C., Han C.S., Tapia R., Land M.L., Hauser L.J.,
RA Kyrpides N.C., Ivanova N.N., Mikhailova N., Pagani I., Woyke T.,
RA Arkin A.P., Dehal P., Chivian D., Criddle C.S., Wu W., Chakraborty R.,
RA Hazen T.C., Fields M.W.;
RT "High-Quality Draft Genome Sequence of Desulfovibrio carbinoliphilus FW-
RT 101-2B, an Organic Acid-Oxidizing Sulfate-Reducing Bacterium Isolated from
RT Uranium(VI)-Contaminated Groundwater.";
RL Genome Announc. 3:0-0(2015).
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CM001368; EHJ46320.1; -; Genomic_DNA.
DR RefSeq; WP_009179767.1; NZ_CM001368.1.
DR AlphaFoldDB; G7QD14; -.
DR STRING; 694327.DFW101_0303; -.
DR eggNOG; COG3276; Bacteria.
DR HOGENOM; CLU_023030_3_0_7; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000004662; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd03696; SelB_II; 1.
DR CDD; cd15491; selB_III; 1.
DR FunFam; 3.40.50.300:FF:001064; Selenocysteine-specific translation elongation factor; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR PANTHER; PTHR43721:SF11; SELENOCYSTEINE-SPECIFIC ELONGATION FACTOR; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:EHJ46320.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000004662}.
FT DOMAIN 1..173
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 639 AA; 68882 MW; D5DEA1B917B9952E CRC64;
MPVIMGTAGH IDHGKTTLIK ALTGIDCDRL AEEKKRGITI ELGFAFMDLP GGTRLGIIDV
PGHERFVKNM VAGAAGIDFV TLVIAADEGV MPQTREHLDI CTLLGVTTGV VALTKADMVD
ADWLAMVTED VRGELAGTFL ADAPIFPVSS HTGAGLPELR EALAALAAGF APRRRSDLAR
LPIDRVFTLK GYGTVVTGTL IAGSFKVGDD VRLFPSEKRS KIRSLQSHGE TVEASPAGRR
TAVNLAGLEV EDVERGEVLA LPGTLFPDLS WEVELTCLPG APRGIKHRTE VHFHHGTREV
LARIHLLDRD KLEPGQTAVC QIRFPEPMAG VHGDRVVVRS GAPLRTMAGG RVLSPMARKV
KRFDEAALAS LAALATAAGP DLIALHLSRA GTDGLGFARL MTLTDLESKA LDKALSGLCD
KGAAALVDRE GKEGRHFVHG TVIADLAASL LDAVAAFHKR EPLKLGLSRS ELASTWGKGL
SPKLFHFVVE RQLRAGKLAT DQDVLRLAGH KVSLASDQAK LRATLLDAYQ KGGLTPPNVK
DILEPLSLTF KEAQPVYKVL QDEGRIVKAQ ENMYFDAEAI KGLIEKVQAY YQAGAADMGP
AEFRELTGLS RKFLIALLEY LDKEKITVRV GDKRQLRKR
//
