ID G7YVU8_CLOSI Unreviewed; 518 AA.
AC G7YVU8;
DT 25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT 25-JAN-2012, sequence version 1.
DT 04-NOV-2026, entry version 56.
DE RecName: Full=Splicing factor U2AF subunit {ECO:0000256|RuleBase:RU364135};
DE AltName: Full=U2 snRNP auxiliary factor large subunit {ECO:0000256|RuleBase:RU364135};
GN ORFNames=CLF_112107 {ECO:0000313|EMBL:GAA57078.1};
OS Clonorchis sinensis (Chinese liver fluke).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC Rhabditophora; Neodermata; Trematoda; Digenea; Opisthorchiida;
OC Opisthorchiata; Opisthorchiidae; Clonorchis.
OX NCBI_TaxID=79923 {ECO:0000313|EMBL:GAA57078.1, ECO:0000313|Proteomes:UP000008909};
RN [1] {ECO:0000313|EMBL:GAA57078.1, ECO:0000313|Proteomes:UP000008909}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=henan {ECO:0000313|Proteomes:UP000008909};
RX PubMed=22023798; DOI=10.1186/gb-2011-12-10-r107;
RA Wang X., Chen W., Huang Y., Sun J., Men J., Liu H., Luo F., Guo L., Lv X.,
RA Deng C., Zhou C., Fan Y., Li X., Huang L., Hu Y., Liang C., Hu X., Xu J.,
RA Yu X.;
RT "The draft genome of the carcinogenic human liver fluke Clonorchis
RT sinensis.";
RL Genome Biol. 12:R107-R107(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Henan;
RA Wang X., Huang Y., Chen W., Liu H., Guo L., Chen Y., Luo F., Zhou W.,
RA Sun J., Mao Q., Liang P., Zhou C., Tian Y., Men J., Lv X., Huang L.,
RA Zhou J., Hu Y., Li R., Zhang F., Lei H., Li X., Hu X., Liang C., Xu J.,
RA Wu Z., Yu X.;
RT "The genome and transcriptome sequence of Clonorchis sinensis provide
RT insights into the carcinogenic liver fluke.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Necessary for the splicing of pre-mRNA.
CC {ECO:0000256|RuleBase:RU364135}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364135}.
CC -!- SIMILARITY: Belongs to the splicing factor SR family.
CC {ECO:0000256|RuleBase:RU364135}.
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DR EMBL; DF144528; GAA57078.1; -; Genomic_DNA.
DR AlphaFoldDB; G7YVU8; -.
DR STRING; 79923.G7YVU8; -.
DR OrthoDB; 10266058at2759; -.
DR Proteomes; UP000008909; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046660; P:female sex differentiation; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-ARBA.
DR CDD; cd12230; RRM1_U2AF65; 1.
DR CDD; cd12231; RRM2_U2AF65; 1.
DR CDD; cd12232; RRM3_U2AF65; 1.
DR FunFam; 3.30.70.330:FF:000074; U2 snRNP auxiliary factor large subunit; 1.
DR FunFam; 3.30.70.330:FF:000097; U2 snRNP auxiliary factor large subunit; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR010519; Tra.
DR InterPro; IPR006529; U2AF_lg.
DR NCBIfam; TIGR01642; U2AF_lg; 1.
DR PANTHER; PTHR23139; RNA-BINDING PROTEIN; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF06495; Transformer; 1.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50102; RRM; 2.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW ECO:0000256|RuleBase:RU364135};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187,
KW ECO:0000256|RuleBase:RU364135};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364135};
KW Reference proteome {ECO:0000313|Proteomes:UP000008909};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU364135}.
SQ SEQUENCE 518 AA; 57832 MW; D900B7F7836DD00E CRC64;
MADYYTGGEF GSSGPGFENQ AQVATESNGN FNNYGNYDRD GESDINSTEY LDRKDRSPRH
RKRDSSSEDR GRDRKRDKKR SRSRSRSRER RRHSRDRHRD RSRERRSKHR HSRHRSETPP
LIYKYWDVPP PGFEHVTPAQ YKAMQASGQI PVNVYAAGQI PMPAHAPNAP LTLTTNIPFA
GSAVCRQARR LYVGNIPFTA TEENMMEFFN KQMRAQGLVQ AEGSPIIAVQ INMEKNFAFL
EFRSVDETTQ GLALDGILFH NQALKLRRPR DYAPLPGVSE TPSVIVPGVV STVVQDSPHK
VFVGGLPNYL NEDQVKELLL SFGPLKGFNL VKDGSTGLSK GYAFCEYVDP NVTDHACAGL
NGMQLGDKKL IVQRASVGAK HNATTAAPAL LQLPGLTDTL VQNTTGTGNI TIRSGGPPTE
VLCLMNMIDP AELEDDEEYE DIVEDVRAEC SKYGVVRSLE IPRPIRGVEV PGVGKIYVEF
ASLIDCQKAA TALTGRKFNQ RLVVTSFFNP DNYHRREF
//
