ID H2AX84_KAZAF Unreviewed; 220 AA.
AC H2AX84;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2012, sequence version 1.
DT 04-NOV-2026, entry version 50.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CCF58984.1};
GN Name=KAFR0F03880 {ECO:0000313|EMBL:CCF58984.1};
GN ORFNames=KAFR_0F03880 {ECO:0000313|EMBL:CCF58984.1};
OS Kazachstania africana (strain ATCC 22294 / BCRC 22015 / CBS 2517 / CECT
OS 1963 / NBRC 1671 / NRRL Y-8276) (Yeast) (Kluyveromyces africanus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX NCBI_TaxID=1071382 {ECO:0000313|EMBL:CCF58984.1, ECO:0000313|Proteomes:UP000005220};
RN [1] {ECO:0000313|EMBL:CCF58984.1, ECO:0000313|Proteomes:UP000005220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22294 / BCRC 22015 / CBS 2517 / CECT 1963 / NBRC 1671 /
RC NRRL Y-8276 {ECO:0000313|Proteomes:UP000005220};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., Oheigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; HE650826; CCF58984.1; -; Genomic_DNA.
DR AlphaFoldDB; H2AX84; -.
DR STRING; 1071382.H2AX84; -.
DR KEGG; kaf:KAFR_0F03880; -.
DR eggNOG; KOG3319; Eukaryota.
DR HOGENOM; CLU_072117_2_1_1; -.
DR InParanoid; H2AX84; -.
DR OMA; AAWCFSQ; -.
DR OrthoDB; 1932233at2759; -.
DR Proteomes; UP000005220; Chromosome 6.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:InterPro.
DR GO; GO:0017059; C:serine palmitoyltransferase complex; IEA:EnsemblFungi.
DR GO; GO:0090156; P:intracellular sphingolipid homeostasis; IEA:EnsemblFungi.
DR GO; GO:0090155; P:negative regulation of sphingolipid biosynthetic process; IEA:EnsemblFungi.
DR GO; GO:0006986; P:response to unfolded protein; IEA:EnsemblFungi.
DR InterPro; IPR007203; ORMDL.
DR PANTHER; PTHR12665; ORMDL PROTEINS; 1.
DR Pfam; PF04061; ORMDL; 1.
DR PIRSF; PIRSF018147; ORMDL; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005220};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 83..102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..24
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 220 AA; 25273 MW; 4F3B7BD7F75AFA72 CRC64;
MNERISRTRT NTNSSSLSRS RANSYLTRSR TNSNKSMAEP FKDHRRKRSS SIISHVEQES
MEDINDQNLL PNMNATWVDQ RGAWIIHIVI IILLKLFFNL LPGITNESAW SLTNTIYVIG
SYIMFHLIKG TPFDFNGGAY DNLTMWEQID DETLYTPTRK FLIILPIILL LISNHYAKFS
YNLFTMNSLI ILFLGVVPKL PSTHRLRIQI PGLIGPAQIT
//
