ID H2LGP0_ORYLA Unreviewed; 3124 AA.
AC H2LGP0;
DT 21-MAR-2012, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 28-JAN-2026, entry version 65.
DE SubName: Full=FRAS1 related extracellular matrix 2a {ECO:0000313|Ensembl:ENSORLP00000005138.2};
GN Name=FREM2 {ECO:0000313|Ensembl:ENSORLP00000005138.2};
GN Synonyms=frem2a {ECO:0000313|Ensembl:ENSORLP00000005138.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|Ensembl:ENSORLP00000005138.2, ECO:0000313|Proteomes:UP000001038};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000005138.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000005138.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|Ensembl:ENSORLP00000005138.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000005138.2};
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSORLP00000005138.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000005138.2};
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SIMILARITY: Belongs to the FRAS1 family.
CC {ECO:0000256|ARBA:ARBA00005529}.
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DR RefSeq; XP_004076347.2; XM_004076299.4.
DR FunCoup; H2LGP0; 100.
DR STRING; 8090.ENSORLP00000005138; -.
DR Ensembl; ENSORLT00000005139.2; ENSORLP00000005138.2; ENSORLG00000004105.2.
DR GeneID; 101170864; -.
DR eggNOG; KOG1306; Eukaryota.
DR eggNOG; KOG2090; Eukaryota.
DR eggNOG; KOG3597; Eukaryota.
DR GeneTree; ENSGT00940000155313; -.
DR HOGENOM; CLU_000394_0_0_1; -.
DR InParanoid; H2LGP0; -.
DR OrthoDB; 430044at2759; -.
DR Proteomes; UP000001038; Chromosome 14.
DR Bgee; ENSORLG00000004105; Expressed in testis and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0033334; P:fin morphogenesis; IEA:Ensembl.
DR FunFam; 2.60.40.2030:FF:000008; FRAS1-related extracellular matrix protein 2; 1.
DR Gene3D; 2.60.40.2030; -; 5.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR039005; CSPG_rpt.
DR InterPro; IPR045658; FRAS1-rel_N.
DR InterPro; IPR051561; FRAS1_ECM.
DR PANTHER; PTHR45739:SF4; FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 2; 1.
DR PANTHER; PTHR45739; MATRIX PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF16184; Cadherin_3; 12.
DR Pfam; PF03160; Calx-beta; 3.
DR Pfam; PF19309; Frem_N; 1.
DR SMART; SM00237; Calx_beta; 5.
DR SUPFAM; SSF141072; CalX-like; 5.
DR PROSITE; PS51854; CSPG; 12.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..3124
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017358701"
FT TRANSMEM 3058..3082
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 271..367
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 390..478
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 499..611
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 636..742
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 763..854
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 880..972
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1001..1103
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1124..1217
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1238..1334
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1355..1447
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1467..1556
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT REPEAT 1590..1687
FT /note="CSPG"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01201"
FT DOMAIN 1694..1793
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 1806..1917
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 1932..2038
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 2053..2155
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 2173..2277
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
SQ SEQUENCE 3124 AA; 346478 MW; 3EB07DD2CB6BA037 CRC64;
MLLRGLLFLC FSVTGIVLAQ RDSSGLFYAL RSELSEDAIL VANNGLRVPF GRSVFIDPIN
DLVIQTQPGD RCSITVLDND PLSQRPGHLS PKKFPCDFGP RDVTYFHYGS RSPAKDRVRL
QLRYDTQTET IIIPFMMEVD VLFTQLELLT KNMPLTVVRL QGISNPIDKK ILEFTYDRDS
FKCEVGLFSS ESSLPRYGKL LDGGKLSTMT DCDEITQAGI RYQHTFNHKS PNKDYIPMVV
ELHDKEDNLV KQECFHLMVR IKEGEENTPP KPSFASMMML EVSQFVMTAV TPDMLAAEDA
ESDPEELIFN ITSSLSYEEG YIVSTDDRNL PITSFYQRDL RDLKIAYVPP SLDSDTERIF
QLEFEVVDTE GAVSDPFAFM IVVKPMNTLA PIVTRNTGQL LYEGQSRPLI SSHNLEISDE
DNLDAVTITV VDGLRHGDLL VLGSHSKFFT SADLTTGIVL YQHDGSDTYS DNIVFKMTDG
KNEVEFLFPI TIVPTDDEPP IINANTGLVL FRNEMVPLSP HMLSAADIDS EDSTIKFTIV
PPFSTIGTVL LRQSDAPEDP SSWKFNTEDE VYEKEVSEWL QKDIIDGKLF YRHTGPHSSG
TVTDQFVFTV QDDNDPPNLS GENSFIIRVL PVDDVPPELF PGTTLQMTVE EYKVTHFSKE
VLRYTDLDSE DRDLKYTVIQ PPMDTDENNP ITFGSLVLTD NPDIKVTEFT QAQVNHHKLS
YAPPDVELGI TAHVVQFRYT VEDTAGNSAE GAFTIYLQPV NNKPPQITNT GFGVFERGMH
IITQAELDAV DLDTKSEEIT FTLSQPPKHG HIQFAFSDLD KKGAFRLADI SNGKISYMHN
GEETVNDGFL LDVSDGIHVV TVTVKVHVKP VDDETPIVTL PAGTVGSRID VLENGATEIT
TDVIQGHDDD TDDLQLTFIV EDPPSLGEIL VKGLPATRFT QADVINGVVV YAHTSGEIGL
NILQDGFNLT LTDMSDDWTV GGNKVSGVHV RVTILPVDNQ APQVGIGIQF SVIEGEKYAI
SPEHVNAEDK DTPSDDILCT IIVQPTAGYL ENISPAPGSE KSRSGTAISA FTIRDIRDGS
IYYVQSIHKG VEPVEDRFTL RCTDGINFSE NHIFPIVIIP ANDEKPEIYL REIVLMEGMN
IVIDTPILNG ADVDVPSEEL VFIISKPPKH GTILNQLSTG SVLVTNFTLE QIKEASSIIY
EHDDSEVSED SFEVILTDGK YSVQKTAMVM IIPVDDETPR MSINDGLEVN IGETKEINNK
VLKATDLDSD DSTLSFIVRF GPSQGHLQRK TSSGSLENVT LGMNFTQAEI DAGLVLYTHN
GQEGIRDLIK FDVTDGINSL IDRYFYITVG SIDMVFPDVV SKGVSLKEGG RVTLTTDLLS
TSDINSPDEN LVFTVTRAPV RGHLECTDTP GMPIVLFSQL QLAGSKIFYV HTSDDEVKMD
SFEFEVTDGY NPVFRTFRIS IVDVDNKKPV LTIKSLVVTE GQLKLITPFE LNAEDQDTNE
KMIRFTVTQL PIHGKLLFNK STPVASFTKQ DLNENLISYK HDGTESSEDS ISFTITDGTH
TDFFVFPDTV YETRRPQTMK ITIVAVDNGV PQIVVNKGAL TLKILTTGHL GLPISPKVLR
AEDRDSRPAS LLFHITTQPK HGYVVNLGHG NNSVDTFSQA DIDDLHICYV LRNEENATSD
VFYFSVEDKG GNKLKDQQFR LDWAWISLEK EYYVVDEEDK HLDVVLRRRG YLGETSFIGI
GTQDGSAKKN EDFKGKLQKQ VQFNPGQTKA TWRVRILADG KYEQAETFQI LLSEPVMGVM
EFPVVATVEI LDPKDESSVF FPEQVHLVEE DVGELFIPVH RSGDVSEELM VICHTQQGSA
KGTIPTTVLS YSDYISRPEE HSSLLRFDRG EREKLCRVVI IDDSLYEGEE SFNLTLSMPV
GGRLGKHYTT TKVNIVEDLD DAPVFYFGEA EYYADESDGY VEVKVWRTGT DLSKAGTVTV
HSRKTEPASA EAGSDYVGLS HNLDFAPGVS MQTFRVFILD DLGQPELEGT ERFELVLRLP
LNGILGEPGK ATVFINDSVS DLPKVQFRKP LYTGEESDGL ITAMVYRSGD IRHKSSVRCY
TRQGSAQVAS DFDERPNTDA SVISFLPGEV EKPCVLTLVD DTLYEEGEEL RLVLGSPRSS
SQFGASVGAP NETLVKIKDT ADKPIIRFLE TKFSVSEPKE AGAVAIVRVP VVRMGDTSKV
SVVRVHTKDG SAVSGEDYYP VSQDIEFRQG DKQHVVQVEV LFDGVREMRE AFTLHLKPDD
NMVAETEMTK VIVYIEESNS MADVTFPSLP HVVSLLHYDD VARTPHNLQP PAGYPVICVT
ACNTKYPDYD KTGSICVSEH INNTLTRYRW LISAPAGPDG VTSPMREVDF DTFFTSSKII
TLDSVYFQAG SRVQCAARAV NSDGDEGLEL SSPIAVISME EGMCQPRKMG TVGAEPFSAK
LRYTGADDPK HPNLIKVTVT MPHIDGMLPV ISTRPLVNFD LTLSPDGTRV GNHRCSNLLD
FSEVTTGHGF ITASTRNPES MGDSAPYQFS SALRGNSTLR FYRNLNLEAC LWEFSSYFHM
SELLTDCGGT IGTDGQVLNL VQSYVTLRVP LYVSYVFHSP VGTGGWQHFD LQSELRLTFV
YDTAILWKDG IGSPPQAELQ GSLFPTSMRI NKQGRLVVNF RTKAHFRGLF VQSHSPGRIK
RSVSSLSMVM SVDNPGLTIN LTLVRSEPTY NQPVQQWIFI SDFAVRDYSG TYTVKLIPCT
TAQTIEYSVP PICSPREPIS FDLNIRFQQV SDPVAVEFSL NTQMFLLSKR SLWLSDGSTN
FGQESDVAFS EGDTIYGRVM VDPVQNLGDS FFCSIEKVFL CTGADGYVPK YNPTNFEFGC
LADSPSLLYR FKILDKAQPE TQALVFGEIG FNAVLAVDDP SALSLVRQPG SDGFRLDSSA
MFQVAAGREW YIHTIYTVRS KDAVSRGIGK RSLEYHSFVS TTDSRALSAR PEAPRKRRSA
GDAIPAVAED IGIDNSRGTN IMHIFLDRTK RKSRVSDELF AGGLEPDELN ADDTEEGLLT
VVGGLVGVLL TVLIIVIITL ILRSKQKDWK EGGRGGVQKV VKGSVSTEPM LVVRMQDCHN
SSEV
//
