ID H2XMI6_CIOIN Unreviewed; 1432 AA.
AC H2XMI6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 18-JUN-2025, entry version 79.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0008006|Google:ProtNLM};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|Ensembl:ENSCINP00000030869.1, ECO:0000313|Proteomes:UP000008144};
RN [1] {ECO:0000313|Proteomes:UP000008144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12481130; DOI=10.1126/science.1080049;
RA Dehal P., Satou Y., Campbell R.K., Chapman J., Degnan B., De Tomaso A.,
RA Davidson B., Di Gregorio A., Gelpke M., Goodstein D.M., Harafuji N.,
RA Hastings K.E., Ho I., Hotta K., Huang W., Kawashima T., Lemaire P.,
RA Martinez D., Meinertzhagen I.A., Necula S., Nonaka M., Putnam N., Rash S.,
RA Saiga H., Satake M., Terry A., Yamada L., Wang H.G., Awazu S., Azumi K.,
RA Boore J., Branno M., Chin-Bow S., DeSantis R., Doyle S., Francino P.,
RA Keys D.N., Haga S., Hayashi H., Hino K., Imai K.S., Inaba K., Kano S.,
RA Kobayashi K., Kobayashi M., Lee B.I., Makabe K.W., Manohar C., Matassi G.,
RA Medina M., Mochizuki Y., Mount S., Morishita T., Miura S., Nakayama A.,
RA Nishizaka S., Nomoto H., Ohta F., Oishi K., Rigoutsos I., Sano M.,
RA Sasaki A., Sasakura Y., Shoguchi E., Shin-i T., Spagnuolo A., Stainier D.,
RA Suzuki M.M., Tassy O., Takatori N., Tokuoka M., Yagi K., Yoshizaki F.,
RA Wada S., Zhang C., Hyatt P.D., Larimer F., Detter C., Doggett N.,
RA Glavina T., Hawkins T., Richardson P., Lucas S., Kohara Y., Levine M.,
RA Satoh N., Rokhsar D.S.;
RT "The draft genome of Ciona intestinalis: insights into chordate and
RT vertebrate origins.";
RL Science 298:2157-2167(2002).
RN [2] {ECO:0000313|Ensembl:ENSCINP00000030869.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=wild type {ECO:0000313|Ensembl:ENSCINP00000030869.1};
RX PubMed=18854010; DOI=10.1186/gb-2008-9-10-r152;
RA Satou Y., Mineta K., Ogasawara M., Sasakura Y., Shoguchi E., Ueno K.,
RA Yamada L., Matsumoto J., Wasserscheid J., Dewar K., Wiley G.B.,
RA Macmil S.L., Roe B.A., Zeller R.W., Hastings K.E., Lemaire P.,
RA Lindquist E., Endo T., Hotta K., Inaba K.;
RT "Improved genome assembly and evidence-based global gene model set for the
RT chordate Ciona intestinalis: new insight into intron and operon
RT populations.";
RL Genome Biol. 9:R152-R152(2008).
RN [3] {ECO:0000313|Ensembl:ENSCINP00000030869.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
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DR EMBL; EAAA01001966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR FunCoup; H2XMI6; 28.
DR STRING; 7719.ENSCINP00000030869; -.
DR Ensembl; ENSCINT00000034381.1; ENSCINP00000030869.1; ENSCING00000022464.1.
DR GeneTree; ENSGT00940000153954; -.
DR HOGENOM; CLU_245006_0_0_1; -.
DR InParanoid; H2XMI6; -.
DR OMA; SEAPRRC; -.
DR TreeFam; TF300805; -.
DR Proteomes; UP000008144; Chromosome 4.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR CDD; cd20347; BRcat_RBR_CUL9; 1.
DR CDD; cd20359; Rcat_RBR_CUL9; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 3.30.230.130; Cullin, Chain C, Domain 2; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR004939; APC_su10/DOC_dom.
DR InterPro; IPR056405; ARM_CUL7_CUL9.
DR InterPro; IPR047561; BRcat_RBR_CUL9.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR047560; Rcat_RBR_CUL9.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR22771:SF4; CULLIN 7-RELATED; 1.
DR PANTHER; PTHR22771; CULLIN AND GALACTOSE-BINDING DOMAIN-CONTAINING; 1.
DR Pfam; PF03256; ANAPC10; 1.
DR Pfam; PF24742; ARM_CUL7_CUL9; 1.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF22191; IBR_1; 1.
DR SMART; SM01337; APC10; 1.
DR SMART; SM00647; IBR; 2.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51284; DOC; 1.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008144};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 91..270
FT /note="DOC"
FT /evidence="ECO:0000259|PROSITE:PS51284"
FT DOMAIN 975..1191
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 979..1027
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 383..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1356..1432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1380..1404
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1413..1432
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1432 AA; 162468 MW; 679030FDE0E383CA CRC64;
QVAEDIVAVL YQLADLDKDF AVELCSLDAK QTINRLLDKH TSIPKTVELR DLIGSCEKQR
ILHNKLLAVV LGGCISTALQ CVEEARNRCS DINIPLFSQL LENLCKGADV EMKEERCWER
LEASTNQRHV LKLTDGNPKT YWESNGSSGG HWVNVYIKKG VIIRKMTITV AQEDSSYMPS
RIVVLGGTSP LDVSTQLSCI NVMSSDREVV LLENMKKFWP MVRISVRRCQ QGGIDTRLHC
LEVVGPKPSF WPILRRQLYV RTSLSYSVQA HVWATEACRG NTEDLKQHQI LDVPAIKYEQ
GFADNFLPNS ECATVLGQAC RVALSSPVFS VLLKTEGEEK QSLLHKLLLA YVTADKDEDR
VFTLKMRKLC RFLMDLDAGI PSPASSKAPE SGSKENSSTW SRKVQPRSGK SDVALCWASI
VFSQFSEIIK NSFSNLQEPL QPSECFKLVE KILSKYKFLQ QSMKNIFGPK SHVSIMLATG
IWRSFLSLTL ETSVRLSYVL SCVIDTIIET YSFKSRPNLL RLKELLPISS GTDFCHVFEH
LYSLFMMERL IRDPPCLEVE EECCGYLLPC FSKHQPSNLL QDAVYSNQLH ERFISKTLEE
HDIDSKNRDQ KWGQYLFLLD GGFRTLIFRQ NVTSFSVVQK GVVGKYLSRL DCRLYSLMHS
FERFYRGQRE ESCLRLTAAS NQTIKWTGEG YAVVFDTLTN KEIRVTTVQM ILLLYFNENK
VVDLEDWKLA FPNQWKVALD VLLKKKVVRE VGDGKFEACE EVLEDLDCSP DVYAPIRSLW
NKTEKIKQHH DRRSSIIDCK IIKKMKQKTE CLSDEIIEEV LRKSTEEEDG FIPEVEHIQA
RCEHLINLGY LTRISRRSIR YNIDSIVNPS AGQLTFLTTA RPLKAWESET EVSVLPSLPI
HSNTLTSDQV ITEIRTEISR LAEILSESVE TAEALLLQFD WHSDKLIESY AVARETTLAS
VGISENSPQK SAEIGSMSCP VCMNALEKGD CVSPICGHLC CKTCWRSYLE MQLSLDKSST
TTCPLNDCTV RPTLSLYRFV FGDDSKNVDK YELGLVRSYV DANKQRSWCH NPRGCDRIVQ
NSGNDVGWCN ACGWQTCFAC TYVEAHSPAS CGHMSQWMDD GGFYEGMNED ARSKHLARLI
AKRCPNCQAN IEKNDGCLHM KCAKCTHDFC WRCLQPWRPS HRDYYNCGTK VSKLAQAGVK
FVEFNKRCRF HHKAKQFAFD LRRRLLSIND SPSPANLQLC LNMCTKLAEF RKVLAYCNVF
QYYSVDSEKL DPIGLYSVAL ENKTLALQEH IGNVLLCCAD IQHTVATVKQ TDLIKGQRLM
NDCEDTVKRL TTFAKQDMKV ALPSSTNQTI KVTDGGTVVV TNDEDNTTFG ANSRPAGDSQ
DNDQDEGNLA SDDDYEYDQS DDDIFSSSQA MQESDDLEYD DDDDDEDDES DP
//
