ID H3BDP7_LATCH Unreviewed; 484 AA.
AC H3BDP7;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 10-JUN-2026, entry version 59.
DE RecName: Full=Centrosomal protein 57kDa-like protein 1 {ECO:0000256|ARBA:ARBA00041218};
DE AltName: Full=Cep57-related protein {ECO:0000256|ARBA:ARBA00042578};
GN Name=CEP57L1 {ECO:0000313|Ensembl:ENSLACP00000020018.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000020018.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Ensembl:ENSLACP00000020018.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JAN-2026) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC -!- SIMILARITY: Belongs to the translokin family.
CC {ECO:0000256|ARBA:ARBA00008179}.
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DR EMBL; AFYH01040103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01040104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01040105; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01040106; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01040107; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H3BDP7; -.
DR Ensembl; ENSLACT00000020156.1; ENSLACP00000020018.1; ENSLACG00000017598.2.
DR GeneTree; ENSGT00530000063695; -.
DR HOGENOM; CLU_034321_0_0_1; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000017598; Expressed in pectoral fin and 2 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR Gene3D; 1.20.58.90; -; 1.
DR InterPro; IPR051756; Centrosomal_MT-associated.
DR InterPro; IPR025913; Cep57_CLD.
DR InterPro; IPR024957; Cep57_MT-bd_dom.
DR PANTHER; PTHR19336:SF10; CENTROSOMAL PROTEIN CEP57L1; 1.
DR PANTHER; PTHR19336; UNCHARACTERIZED DUF1167; 1.
DR Pfam; PF14073; Cep57_CLD; 1.
DR Pfam; PF06657; Cep57_MT_bd; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 58..233
FT /note="Cep57 centrosome localisation"
FT /evidence="ECO:0000259|Pfam:PF14073"
FT DOMAIN 337..407
FT /note="Cep57 centrosome microtubule-binding"
FT /evidence="ECO:0000259|Pfam:PF06657"
FT REGION 233..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 56..218
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 380..431
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 242..251
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 484 AA; 55350 MW; 7BB17A4FB9EEFADD CRC64;
MESSVHNRFL GSFYLPREKL SAFAFPTYKQ AESPTVDTGS ERLTGQTTGM RSASNSQALA
TALKTLQEKI HRLELERSKA ADNFKQLSSQ TTLYGKVLEH EKDLEYAGLT KQNNELSCQL
SAAKARCSIL EKQLEYMREM MENAEAEKNI LLEKQQSSLQ NEKSTNPVEL HTKLEKLENL
ERECLKLTTT QNATEDKIQQ LQQKLHEEEH QRKLIQDKAA QLQTGLEMNR ILLTSVSPQK
EPKKKIKKKQ SSKQNASLKE ETSQTRVSKK HAELPFVAGK SASPSHSLRA NVQNVLYMMK
HYRPQMCERK PRSCYHRVLR NKNIKQEVGR PVSACSTSSS VSFEGLSELL LALQDELGQM
SFEHQELVKQ IHETKNTAVR EDLERELDSL VKQMELKGDQ ISNLKKHQVK VQTLKQKAQQ
MKKKRTHAKS RGGKVNGVQK QMVTPRQIHG KTPPGQKSKV SLQLLKDVQK LQMTLKKDDI
MWEQ
//
