GenomeNet

Database: UniProt
Entry: H3BR01
LinkDB: H3BR01
Original site: H3BR01 
ID   H3BR01_HUMAN            Unreviewed;       240 AA.
AC   H3BR01;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   29-SEP-2021, entry version 57.
DE   SubName: Full=Kunitz-type protease inhibitor 1 {ECO:0000313|Ensembl:ENSP00000456015};
DE   Flags: Fragment;
GN   Name=SPINT1 {ECO:0000313|Ensembl:ENSP00000456015};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000456015, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000456015, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S.,
RA   Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R.,
RA   Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0007829|PubMed:18669648}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [3] {ECO:0000313|Ensembl:ENSP00000456015}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC012476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PeptideAtlas; H3BR01; -.
DR   PRIDE; H3BR01; -.
DR   ProteomicsDB; 41934; -.
DR   Antibodypedia; 1540; 444 antibodies.
DR   Ensembl; ENST00000566928; ENSP00000456015; ENSG00000166145.
DR   UCSC; uc059hvx.1; human.
DR   HGNC; HGNC:11246; SPINT1.
DR   OpenTargets; ENSG00000166145; -.
DR   VEuPathDB; HostDB:ENSG00000166145; -.
DR   GeneTree; ENSGT00940000161683; -.
DR   ChiTaRS; SPINT1; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000166145; Expressed in lower esophagus mucosa and 187 other tissues.
DR   ExpressionAtlas; H3BR01; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   CDD; cd00109; KU; 2.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 4.10.410.10; -; 2.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR002223; Kunitz_BPTI.
DR   InterPro; IPR036880; Kunitz_BPTI_sf.
DR   InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR   InterPro; IPR042482; Spint1.
DR   PANTHER; PTHR46750; PTHR46750; 2.
DR   Pfam; PF00014; Kunitz_BPTI; 2.
DR   PRINTS; PR00759; BASICPTASE.
DR   SMART; SM00131; KU; 2.
DR   SUPFAM; SSF57362; SSF57362; 2.
DR   PROSITE; PS00280; BPTI_KUNITZ_1; 2.
DR   PROSITE; PS50279; BPTI_KUNITZ_2; 2.
PE   1: Evidence at protein level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|MaxQB:H3BR01,
KW   ECO:0007829|PeptideAtlas:H3BR01};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        216..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          68..118
FT                   /note="BPTI/Kunitz inhibitor"
FT                   /evidence="ECO:0000259|PROSITE:PS50279"
FT   DOMAIN          151..201
FT                   /note="BPTI/Kunitz inhibitor"
FT                   /evidence="ECO:0000259|PROSITE:PS50279"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000456015"
FT   NON_TER         240
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000456015"
SQ   SEQUENCE   240 AA;  27328 MW;  3D41B8E60C47BBD0 CRC64;
     XVENTDWRLL RGDTDVRVER KDPNQVELWG LKEGTYLFQL TVTSSDHPED TANVTVTVLS
     TKQTEDYCLA SNKVGRCRGS FPRWYYDPTE QICKSFVYGG CLGNKNNYLR EEECILACRG
     VQGPSMERRH PDTSGFDELQ RIHFPSDKGH CVDLPDTGLC KESIPRWYYN PFSEHCARFT
     YGGCYGNKNN FEEEQQCLES CRGISKKDVF GLRREIPIPS TGSVEMAVAV FLVICIVVVV
//
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