ID H3D9K6_TETNG Unreviewed; 1174 AA.
AC H3D9K6;
DT 18-APR-2012, integrated into UniProtKB/TrEMBL.
DT 18-APR-2012, sequence version 1.
DT 28-JAN-2026, entry version 62.
DE SubName: Full=Bromodomain adjacent to zinc finger domain, 1B {ECO:0000313|Ensembl:ENSTNIP00000017197.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|Ensembl:ENSTNIP00000017197.1, ECO:0000313|Proteomes:UP000007303};
RN [1] {ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|Ensembl:ENSTNIP00000017197.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSTNIP00000017197.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00475}.
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DR AlphaFoldDB; H3D9K6; -.
DR FunCoup; H3D9K6; 708.
DR STRING; 99883.ENSTNIP00000017197; -.
DR Ensembl; ENSTNIT00000017413.1; ENSTNIP00000017197.1; ENSTNIG00000014185.1.
DR GeneTree; ENSGT00940000156831; -.
DR InParanoid; H3D9K6; -.
DR OMA; KVCRRKV; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0090535; C:WICH complex; IEA:InterPro.
DR GO; GO:0042393; F:histone binding; IEA:TreeGrafter.
DR GO; GO:0140801; F:histone H2AXY142 kinase activity; IEA:InterPro.
DR GO; GO:0006974; P:DNA damage response; IEA:TreeGrafter.
DR InterPro; IPR047174; BAZ1B.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR028942; WHIM1_dom.
DR InterPro; IPR028941; WHIM2_dom.
DR InterPro; IPR013136; WSTF_Acf1_Cbp146.
DR PANTHER; PTHR46802; TYROSINE-PROTEIN KINASE BAZ1B; 1.
DR PANTHER; PTHR46802:SF1; TYROSINE-PROTEIN KINASE BAZ1B; 1.
DR Pfam; PF10537; WAC_Acf1_DNA_bd; 1.
DR Pfam; PF15612; WHIM1; 1.
DR Pfam; PF15613; WSD; 1.
DR SMART; SM00571; DDT; 1.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS51136; WAC; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00475}; Reference proteome {ECO:0000313|Proteomes:UP000007303}.
FT DOMAIN 24..130
FT /note="WAC"
FT /evidence="ECO:0000259|PROSITE:PS51136"
FT DOMAIN 605..669
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 445..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 851..870
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 536..574
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 149..170
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..195
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..420
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..832
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1174 AA; 134293 MW; E7190F7CE389CD45 CRC64;
MAPLLGRKPY PLAKPLTEPP GPGDEIYTIE HTKEAFRNKE EYEARLQRYK ERIWTCKSTG
SSQLTHQEAW EEEQEVTALL EEEFPRWFEK PVLEIVHHNT VSLDKLVEKA WLEILTKYAV
GEECDFLVGK DKTLQVKIVK IHPLEHPEGE AAEKKLDGTC DSPSSDKENA SQEAQSKVPS
SREESRREMP SDQARRSPRK LPTAMKEEKK KWVMPKFLPY KYDVKLINED KVISDVPADS
LYRTERPPTK EIMRYFIRHK ALRLGMGESS PWVVEDELVK KFNLPSKLSD FLLHPHKFLA
ENPSVKRRSL TSPDGRPQKK HKTSITSGKD SEVWLRADLQ KMMAGHLISS IVKSIYLQNS
NSMQEKIKMN GSPLKVTNSG TPKKGEGKSS GLTTSKSGKK SGDKKDGKKN GKGADKKLDV
LKASKKDIKA GAQPKMKQMT LLHLAKSTPA ASPKKRSRSS GMSSPKLGKP LHPMALHLLR
YYKENKGKED KKNALSSLIS KAAKNLPSEE WGRLPEELKE LVQKRWELLE HKKRWAAMSE
EEKQEEMKKK REELKEKLRE KAKERREKEM LVRREMSRRY EDQEIDDGKS LPAFKLVDMP
EGLPNTLFGN VALIVDFLYC YTELLMPDDQ YPITAVALME ALAGERSGFL YLNRVLVVLL
QTLLQDELAE GYSELDMPLS EIPLTMHSAS ELARLCLRPC DSQDEASGRG SEKSAGFGDF
DDVVSSEFLE KLETCEVFEL TPEEKVNLLV ALCHRILMTY SVEDHVYAKQ QRAAELWKER
AAMLKEVNDR KRAERQKQKE KEGKGQWEQK PCEKKKDGTS KDKIKKEVKV EPEPEDMIST
VKSRRLMSMQ AKKEKEEMDR QNKERMEKEA EEERIRRQKA AAERAFQDGI TKAKLVLRRT
PLGTDRNHNR YWLFSDLVPG LYIEKGWVHE SIEYSFTPPD EKPAEFDAVD EVDTGSDTAN
HSQGHGAAAA DICIETTAPK QGQNLWFICD THGEFEELVE SLHPQGVRES ELKLNIQNRY
QEILHSIHLT RKSKLSLRSC DGYAELLKYL RSDIQEIASR LQKGGLGYLD DNVDIEDQLG
NMESLKDFGE CVISIQAGVI KKFLQGFMAP KQKKKRKGGE ESSKAEEFDE EKRLAEEARV
ATAVENWKNA IREAQTFSRM HVLLGMLDAS IKWD
//
