ID I1HE44_BRADI Unreviewed; 1065 AA.
AC I1HE44;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 28-JAN-2026, entry version 65.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=LOC100842535 {ECO:0000313|EnsemblPlants:KQK03708};
GN ORFNames=BRADI_2g09427v3 {ECO:0000313|EMBL:KQK03708.1};
OS Brachypodium distachyon (Purple false brome) (Trachynia distachya).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Stipodae; Brachypodieae; Brachypodium.
OX NCBI_TaxID=15368 {ECO:0000313|EMBL:KQK03708.1};
RN [1] {ECO:0000313|EMBL:KQK03708.1, ECO:0000313|EnsemblPlants:KQK03708}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQK03708.1,
RC ECO:0000313|EnsemblPlants:KQK03708};
RX PubMed=20148030; DOI=10.1038/nature08747;
RG International Brachypodium Initiative;
RT "Genome sequencing and analysis of the model grass Brachypodium
RT distachyon.";
RL Nature 463:763-768(2010).
RN [2] {ECO:0000313|EMBL:KQK03708.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQK03708.1};
RG The International Brachypodium Initiative;
RA Lucas S., Harmon-Smith M., Lail K., Tice H., Grimwood J., Bruce D.,
RA Barry K., Shu S., Lindquist E., Wang M., Pitluck S., Vogel J.P.,
RA Garvin D.F., Mockler T.C., Schmutz J., Rokhsar D., Bevan M.W.;
RT "WGS assembly of Brachypodium distachyon.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQK03708}
RP IDENTIFICATION.
RC STRAIN=cv. Bd21 {ECO:0000313|EnsemblPlants:KQK03708};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; CM000881; KQK03708.1; -; Genomic_DNA.
DR RefSeq; XP_003565611.1; XM_003565563.4.
DR AlphaFoldDB; I1HE44; -.
DR FunCoup; I1HE44; 452.
DR STRING; 15368.I1HE44; -.
DR EnsemblPlants; KQK03708; KQK03708; BRADI_2g09427v3.
DR GeneID; 100842535; -.
DR Gramene; KQK03708; KQK03708; BRADI_2g09427v3.
DR KEGG; bdi:100842535; -.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_000837_25_2_1; -.
DR OMA; WNSSFRN; -.
DR OrthoDB; 597744at2759; -.
DR Proteomes; UP000008810; Chromosome 2.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0098542; P:defense response to other organism; IBA:GO_Central.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR055414; LRR_R13L4/SHOC2-like.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1227; OS11G0462500 PROTEIN; 1.
DR Pfam; PF23598; LRR_14; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000008810};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 10..93
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 205..354
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 552..913
FT /note="Disease resistance R13L4/SHOC-2-like LRR"
FT /evidence="ECO:0000259|Pfam:PF23598"
SQ SEQUENCE 1065 AA; 118446 MW; EDA3E6F0D2D06EE9 CRC64;
METAVATAFL TKIAPKLFAF LQEKHKRRQN LERDIQYIRK EFRMIAAAIQ DHDRRRGLQR
SDGDDVQRVW IQLVRDLAYS IEDCVDRFTH RVRLPPPPKP DGSTPSWLRK TVHGVKTATT
RSKFATAVRE LRKISEEASK LRACYIGSGG GGGCQSSTSG LSASSSTFFS SCETTTHTIA
ADLVGMDVPR DEVLQLMRET QGQPKQLKVI SIVGFGGLGK TLLAREVYDE SGDGQYEPRA
WVRAAERGAG DVLKEILHEL GMQVPDGGDI NKLSTSIRDC LGSKRFFIVI DDMRKEFWNI
IKNAFPAVSG VSSRVVVTTA VHSIANACSS FAHGHVYMMR TLDEENSRRL FFKQASLDDP
PPDAGLGSEA LKKSDGLPLA LVTVAQFLQS RGNPTRTEWA KLCNNLGELL ETKDTLARMN
RVLADSYSSL TDHVLKACLL YMGIFPGGRP VRTESLLRRL LAEGFVEECG VANDRFKELV
DRSIVLPVAV NNNTELKTCQ THGMMLEFIL RKSVQESFVT LLHGQDRPPG DGKIRWLSLN
HYSGNPSNDL SHVRSLTVFG KAHKSVLEFS KYELLRVLDL EECDDYLDDK HLLEICNLLL
LRYLSLRGNK TITVLPKEIS KLKYLETLDL TRTKIEVLPI QVLKMTSLIH LFGAFKLEDV
GRKVSKLQAF LSEKSKLETL KGFVADESQI FAQLLQHMEH LTKVKIRWVP TVDGSSNLNH
LSDAIQGFIE RSTNMNDAHS LSLGSTEWPQ DLLNFSLENS CYLHSLKLHG NSICSLPPFV
TMLGGLTELC LSSPNNQLSG DILASVSTVR CLHYLKLTAN QLGSLEIENG VLGSLRGLCI
VVQSMAGLDI KKGALQRLES LRLLCKDLDG RVLCGINMEC LRQLKEVALH DGVSDGAKQD
WKEAAKKHPK QPKVLFMQTM EDVDWMQMGS SNENSESCAA PTPMSEDDVQ TQVGSVMQKS
PAGTIARLIH GSKRTNNHLG HHLCEFDNQS KQELEAAASK QPKRPKVLFV GTVEDVDVTM
QMEHSAATAT VAVADVQMRP SEGREHSIAG KIAGLTRHFK RRRFL
//
