ID I3N5N8_ICTTR Unreviewed; 707 AA.
AC I3N5N8;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 28-JAN-2026, entry version 63.
DE RecName: Full=Zinc finger protein 750 {ECO:0000256|ARBA:ARBA00040216};
GN Name=ZNF750 {ECO:0000313|Ensembl:ENSSTOP00000019684.1};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000019684.1, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000019684.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2025) to UniProtKB.
RN [3] {ECO:0000313|Ensembl:ENSSTOP00000019684.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AGTP01117550; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01117551; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005342029.1; XM_005341972.3.
DR RefSeq; XP_040124238.1; XM_040268304.1.
DR AlphaFoldDB; I3N5N8; -.
DR FunCoup; I3N5N8; 1023.
DR STRING; 43179.ENSSTOP00000019684; -.
DR Ensembl; ENSSTOT00000025597.2; ENSSTOP00000019684.1; ENSSTOG00000023707.2.
DR GeneID; 101973040; -.
DR KEGG; iti:101973040; -.
DR CTD; 79755; -.
DR eggNOG; ENOG502QU7X; Eukaryota.
DR GeneTree; ENSGT00530000063870; -.
DR HOGENOM; CLU_023455_0_0_1; -.
DR InParanoid; I3N5N8; -.
DR OMA; PSAYDHY; -.
DR OrthoDB; 8933073at2759; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0061436; P:establishment of skin barrier; IEA:Ensembl.
DR GO; GO:0044091; P:membrane biogenesis; IEA:Ensembl.
DR GO; GO:0010719; P:negative regulation of epithelial to mesenchymal transition; IEA:Ensembl.
DR GO; GO:2000304; P:positive regulation of ceramide biosynthetic process; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR InterPro; IPR039363; ZNF750.
DR InterPro; IPR039064; ZNF750_Znf.
DR PANTHER; PTHR14678; PROLINE-RICH PROTEIN 35-RELATED; 1.
DR PANTHER; PTHR14678:SF1; ZINC FINGER PROTEIN 750; 1.
DR Pfam; PF15269; zf-C2H2_7; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 6..57
FT /note="Zinc finger protein 750-like zinc finger"
FT /evidence="ECO:0000259|Pfam:PF15269"
FT REGION 60..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 631..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..362
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..392
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..662
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 707 AA; 75680 MW; E721CCA07F41E34B CRC64;
MSLLKERKPK KPHYIPRPPG KPFKYKCFQC PFTCNEKSHL FNHMKYGLCK NSITLVSEQD
RGPRCPRAHA PDPRPPRQQA PTAQLASPQP LTDGLPGFDP KPQQGSGKED VQESLKLQAR
RTHALPQKPG LQQEEAPEAA RGTQPALDLA RPSAFIPVGE HRLKGPENTE GPETLSSTNP
TTKATAFHTK SAFHAPGYPW KAGSPFLPPE FPHKIPPTKG FSAISPYVHP TIPEYPPPFY
AEHGLAAIYS PYLLAGSAPE CDTTLLSVYG APDQRHFLPP PGPLPKHLTP SPSTYDHYRF
LQQFHPSLPV PYGFYRPESA FSSYSLRLPP LAGITREQSS RLLEEATLAH PASSPSELSP
SNSHKKHTEF EKESPIPEAK DPSKDGQRDL EGAKMSPRAG SAATGSPGRP SPTNFTQTSQ
ACEGLCDLSN KGSPSALGWR PQPEQSPTAF RPVPKNTDCP HSQVPANSTE SPHSLEAGNG
DPPAQTASPL PTTEAAHAIP EDGSRTGPLN LSKKSEPRPA AAGGAMYPGS AKAEAPGFTE
LQDLPLNLSV KDPCNARAPR PAVPSPLQSA EPAAAPRTGR GSPRDGSSCA EAQQEEGPGG
KAPASRVVDS SDEQKQTAAV ALCQLAAYSP GNVRVGEGEP TTQESGCQDA PTPSSTESQG
TQCDLRPKGQ KRASQRDTGK PQQGSKKTKP SDTAARVFTL RKRTRVS
//
