ID I4ESB6_MODI5 Unreviewed; 426 AA.
AC I4ESB6;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 28-JAN-2026, entry version 56.
DE SubName: Full=Cyclopropane-fatty-acyl-phospholipid synthase {ECO:0000313|EMBL:CCH86279.1};
GN OrderedLocusNames=MODMU_0828 {ECO:0000313|EMBL:CCH86279.1};
OS Modestobacter italicus (strain DSM 44449 / CECT 9708 / BC 501).
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Modestobacter.
OX NCBI_TaxID=2732864 {ECO:0000313|EMBL:CCH86279.1, ECO:0000313|Proteomes:UP000006461};
RN [1] {ECO:0000313|EMBL:CCH86279.1, ECO:0000313|Proteomes:UP000006461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BC 501 {ECO:0000313|Proteomes:UP000006461};
RX PubMed=22887672; DOI=10.1128/JB.01029-12;
RA Normand P., Gury J., Pujic P., Chouaia B., Crotti E., Brusetti L.,
RA Daffonchio D., Vacherie B., Barbe V., Medigue C., Calteau A.,
RA Ghodhbane-Gtari F., Essoussi I., Nouioui I., Abbassi-Ghozzi I., Gtari M.;
RT "Genome Sequence of Radiation-Resistant Modestobacter marinus Strain BC501,
RT a Representative Actinobacterium That Thrives on Calcareous Stone
RT Surfaces.";
RL J. Bacteriol. 194:4773-4774(2012).
CC -!- SIMILARITY: Belongs to the CFA/CMAS family.
CC {ECO:0000256|ARBA:ARBA00010815}.
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DR EMBL; FO203431; CCH86279.1; -; Genomic_DNA.
DR AlphaFoldDB; I4ESB6; -.
DR STRING; 477641.MODMU_0828; -.
DR KEGG; mmar:MODMU_0828; -.
DR PATRIC; fig|477641.3.peg.774; -.
DR eggNOG; COG2230; Bacteria.
DR HOGENOM; CLU_026434_6_2_11; -.
DR OMA; WKPGELG; -.
DR OrthoDB; 9782855at2; -.
DR Proteomes; UP000006461; Chromosome.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR050723; CFA/CMAS.
DR InterPro; IPR003333; CMAS.
DR InterPro; IPR020803; MeTfrase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR43667; CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE; 1.
DR PANTHER; PTHR43667:SF1; CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE; 1.
DR Pfam; PF02353; CMAS; 1.
DR PIRSF; PIRSF003085; CMAS; 1.
DR SMART; SM00828; PKS_MT; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000006461};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 157..419
FT /note="Polyketide synthase-like methyltransferase"
FT /evidence="ECO:0000259|SMART:SM00828"
FT REGION 118..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 426 AA; 46603 MW; DDB483FB601A77F4 CRC64;
MTKKRTVADR LAEALGAVLG TTELPVRLRG WDGSITGPAG APVVAVHSRR ALRRMLWSPG
QLGIGRAYVA GEIDMEDDVF ATFSALRTDS RLAQEKPPSN WSWRDRLTLL GTALRLGAIG
PEPEPPAEEA RPASGNRHTR VRDAAAIAHH YDVGNDFYEL VLGPSMVYSC AVWASPETGL
DAAQEAKLDL VCRKLGLAPG SRLLDVGCGW GSMAIHAAQR YGATVVGVTL SEEQARMARK
RVAEAGLTDK IDIRVQDYRA VDDEPFDAIS SIGMAEHVGR AQMPEYVAQL DRLLRPGGRL
LNHAISWNAG VSTWRPDSFI ARYVFPDGEL LNLGETVSLL ESRDLEVLDV EALRQHYALT
LRAWVQHLEQ NWDAAVAASS EGRARVWRLY MAASALTFEA GDMGVNQVLL QKTGGEQPPL
RRTAWL
//
