ID I4EUX5_MODI5 Unreviewed; 579 AA.
AC I4EUX5;
DT 05-SEP-2012, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2012, sequence version 1.
DT 28-JAN-2026, entry version 63.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN Name=selB {ECO:0000313|EMBL:CCH87188.1};
GN OrderedLocusNames=MODMU_1749 {ECO:0000313|EMBL:CCH87188.1};
OS Modestobacter italicus (strain DSM 44449 / CECT 9708 / BC 501).
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Geodermatophilales;
OC Geodermatophilaceae; Modestobacter.
OX NCBI_TaxID=2732864 {ECO:0000313|EMBL:CCH87188.1, ECO:0000313|Proteomes:UP000006461};
RN [1] {ECO:0000313|EMBL:CCH87188.1, ECO:0000313|Proteomes:UP000006461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BC 501 {ECO:0000313|Proteomes:UP000006461};
RX PubMed=22887672; DOI=10.1128/JB.01029-12;
RA Normand P., Gury J., Pujic P., Chouaia B., Crotti E., Brusetti L.,
RA Daffonchio D., Vacherie B., Barbe V., Medigue C., Calteau A.,
RA Ghodhbane-Gtari F., Essoussi I., Nouioui I., Abbassi-Ghozzi I., Gtari M.;
RT "Genome Sequence of Radiation-Resistant Modestobacter marinus Strain BC501,
RT a Representative Actinobacterium That Thrives on Calcareous Stone
RT Surfaces.";
RL J. Bacteriol. 194:4773-4774(2012).
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; FO203431; CCH87188.1; -; Genomic_DNA.
DR AlphaFoldDB; I4EUX5; -.
DR STRING; 477641.MODMU_1749; -.
DR KEGG; mmar:MODMU_1749; -.
DR PATRIC; fig|477641.3.peg.1647; -.
DR eggNOG; COG3276; Bacteria.
DR HOGENOM; CLU_023030_1_1_11; -.
DR OMA; HYAMLIV; -.
DR Proteomes; UP000006461; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:CCH87188.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000006461}.
FT DOMAIN 1..168
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 579 AA; 60487 MW; 2F809FAEFD6A7E0F CRC64;
MIATAGHVDH GKSALVRALT GMEPDRWEEE RRRGLTIDLG FAWTTLPSGR RVAVVDVPGH
ERFIGNMLAG VGSVPTALVV VAADDGWSAQ TAEHVAVLDA LGVRAGLLAV TKADLADPAP
VLADARERLA GTSLGRLPAV AVSARTGAGL PELTAALERV LAGLPAPDPA APVRLWVDRA
FTIRGAGTVV TGTLAAGTLT AGDRLDLGGR TVTVRGLQSL GAPVETAVAT ARVALNLRGV
AVEEISRGDA LLTPDAFRRT ADLDVTLVAP VEGTLPAEAV VHIGSATVAA RVRPLDGTAV
RLRLAHELPL RVGDRLLLRD PGVRRVLGAD VRDVDPPELR RRGAARSRAA ELAEQPAGAE
GAAADLARRR FVRRADFVAM GWPVPAGTTT VGPWLVAPGL ADELAARVPQ VVARYRQLRP
LEPGPPLAVL RSALELPDVE LVPAVVRAPL ELREGRVVAA DPGLPAAVQR AVDGIRARLA
AEPFAAPEAG DLVAAGLGTR ELAAAVRAEQ LVRIADGVYL APGVAEVARA RLAGLPSPFT
LSEARQAWGT TRRVAVPLAE WLDARGITVR LPDNTRRLR
//
