GenomeNet

Database: UniProt
Entry: J3QS39
LinkDB: J3QS39
Original site: J3QS39 
ID   J3QS39_HUMAN            Unreviewed;        93 AA.
AC   J3QS39;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   02-JUN-2021, entry version 70.
DE   SubName: Full=Polyubiquitin-B {ECO:0000313|Ensembl:ENSP00000464510};
DE   Flags: Fragment;
GN   Name=UBB {ECO:0000313|Ensembl:ENSP00000464510};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000464510, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000464510, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000464510}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
RN   [3] {ECO:0007829|PDB:6NJ9, ECO:0007829|PDB:6NOG}
RP   STRUCTURE BY ELECTRON MICROSCOPY (2.96 ANGSTROMS) OF 1-76.
RX   PubMed=30765112; DOI=10.1016/j.cell.2019.02.002;
RA   Worden E.J., Hoffmann N.A., Hicks C.W., Wolberger C.;
RT   "Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by
RT   Dot1L.";
RL   Cell 176:1490-1501.e12(2019).
RN   [4] {ECO:0007829|PDB:7BU0}
RP   X-RAY CRYSTALLOGRAPHY (2.43 ANGSTROMS) OF 1-75.
RX   PubMed=33136002; DOI=10.7554/elife.58114;
RA   Liu S., Luo J., Zhen X., Qiu J., Ouyang S., Luo Z.Q.;
RT   "Interplay between bacterial deubiquitinase and ubiquitin E3 ligase
RT   regulates ubiquitin dynamics on Legionella phagosomes.";
RL   Elife 9:0-0(2020).
RN   [5] {ECO:0007829|PDB:7BBD}
RP   X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 1-74.
RA   Kiss L., Clift D., Neuhaus D., James L.C.;
RT   "RING domains act as both substrate and enzyme in a catalytic arrangement
RT   to drive self-anchored ubiquitination.";
RL   Submitted (DEC-2020) to the PDB data bank.
CC   -!- INTERACTION:
CC       J3QS39; PRO_0000449621 [P0DTD1]: rep; Xeno; NbExp=6; IntAct=EBI-25691162, EBI-25492388;
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC093484; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PDB; 6NJ9; EM; 2.96 A; L=1-76.
DR   PDB; 6NOG; EM; 3.90 A; L=1-76.
DR   PDB; 7BBD; X-ray; 2.20 A; B=1-74.
DR   PDB; 7BU0; X-ray; 2.43 A; C/D=1-75.
DR   PDBsum; 6NJ9; -.
DR   PDBsum; 6NOG; -.
DR   PDBsum; 6OAM; -.
DR   PDBsum; 6TBM; -.
DR   SMR; J3QS39; -.
DR   IntAct; J3QS39; 1.
DR   SwissPalm; J3QS39; -.
DR   MaxQB; J3QS39; -.
DR   PeptideAtlas; J3QS39; -.
DR   PRIDE; J3QS39; -.
DR   Antibodypedia; 4579; 639 antibodies.
DR   Ensembl; ENST00000578706; ENSP00000464510; ENSG00000170315.
DR   UCSC; uc060bsc.1; human.
DR   HGNC; HGNC:12463; UBB.
DR   OpenTargets; ENSG00000170315; -.
DR   VEuPathDB; HostDB:ENSG00000170315.13; -.
DR   GeneTree; ENSGT00940000162439; -.
DR   HOGENOM; CLU_010412_6_3_1; -.
DR   ChiTaRS; UBB; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000170315; Expressed in hypothalamus and 248 other tissues.
DR   ExpressionAtlas; J3QS39; baseline and differential.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR019954; Ubiquitin_CS.
DR   InterPro; IPR019956; Ubiquitin_dom.
DR   Pfam; PF00240; ubiquitin; 1.
DR   PRINTS; PR00348; UBIQUITIN.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS00299; UBIQUITIN_1; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:6NJ9, ECO:0007829|PDB:6NOG};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:J3QS39};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN          1..76
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50053"
FT   NON_TER         93
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000464510"
SQ   SEQUENCE   93 AA;  10469 MW;  666B0F57D365A5A7 CRC64;
     MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN
     IQKESTLHLV LRLRGGMQIF VKTLTGKTIT LEV
//
DBGET integrated database retrieval system