ID J7S8G4_HUIN7 Unreviewed; 658 AA.
AC J7S8G4;
DT 31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 1.
DT 28-JAN-2026, entry version 48.
DE RecName: Full=DBF4-type domain-containing protein {ECO:0000259|PROSITE:PS51265};
GN Name=KNAG0H01060 {ECO:0000313|EMBL:CCK71519.1};
GN OrderedLocusNames=KNAG_0H01060 {ECO:0000313|EMBL:CCK71519.1};
OS Huiozyma naganishii (strain ATCC MYA-139 / BCRC 22969 / CBS 8797 / KCTC
OS 17520 / NBRC 10181 / NCYC 3082 / Yp74L-3) (Yeast) (Kazachstania
OS naganishii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Huiozyma.
OX NCBI_TaxID=1071383 {ECO:0000313|EMBL:CCK71519.1, ECO:0000313|Proteomes:UP000006310};
RN [1] {ECO:0000313|EMBL:CCK71519.1, ECO:0000313|Proteomes:UP000006310}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520
RC / NBRC 10181 / NCYC 3082 {ECO:0000313|Proteomes:UP000006310};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., Oheigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
RN [2] {ECO:0000313|Proteomes:UP000006310}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520
RC / NBRC 10181 / NCYC 3082 {ECO:0000313|Proteomes:UP000006310};
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Genome sequence of Kazachstania naganishii.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; HE978321; CCK71519.1; -; Genomic_DNA.
DR RefSeq; XP_022465764.1; XM_022609360.1.
DR AlphaFoldDB; J7S8G4; -.
DR STRING; 1071383.J7S8G4; -.
DR GeneID; 34527251; -.
DR KEGG; kng:KNAG_0H01060; -.
DR eggNOG; KOG4139; Eukaryota.
DR HOGENOM; CLU_023948_0_0_1; -.
DR OMA; IITLEWK; -.
DR OrthoDB; 21380at2759; -.
DR Proteomes; UP000006310; Chromosome 8.
DR GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:EnsemblFungi.
DR GO; GO:0031431; C:Dbf4-dependent protein kinase complex; IEA:EnsemblFungi.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:EnsemblFungi.
DR GO; GO:0043539; F:protein serine/threonine kinase activator activity; IEA:EnsemblFungi.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006270; P:DNA replication initiation; IEA:EnsemblFungi.
DR GO; GO:0033314; P:mitotic DNA replication checkpoint signaling; IEA:EnsemblFungi.
DR GO; GO:0001100; P:negative regulation of exit from mitosis; IEA:EnsemblFungi.
DR GO; GO:1903468; P:positive regulation of DNA replication initiation; IEA:EnsemblFungi.
DR GO; GO:0060903; P:positive regulation of meiosis I; IEA:EnsemblFungi.
DR GO; GO:0006279; P:premeiotic DNA replication; IEA:EnsemblFungi.
DR FunFam; 6.10.250.3410:FF:000001; Protein DBF4 homolog A; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 6.10.250.3410; DBF zinc finger; 1.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR055116; DBF4_BRCT.
DR InterPro; IPR013939; Regulatory_Dfp1/Him1.
DR InterPro; IPR051590; Replication_Regulatory_Kinase.
DR InterPro; IPR006572; Znf_DBF.
DR InterPro; IPR038545; Znf_DBF_sf.
DR PANTHER; PTHR15375; ACTIVATOR OF S-PHASE KINASE-RELATED; 1.
DR PANTHER; PTHR15375:SF26; PROTEIN CHIFFON; 1.
DR Pfam; PF22437; DBF4_BRCT; 1.
DR Pfam; PF08630; Dfp1_Him1_M; 1.
DR Pfam; PF07535; zf-DBF; 1.
DR SMART; SM00586; ZnF_DBF; 1.
DR PROSITE; PS51265; ZF_DBF4; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000006310};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00600}.
FT DOMAIN 608..657
FT /note="DBF4-type"
FT /evidence="ECO:0000259|PROSITE:PS51265"
FT REGION 32..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 442..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..43
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 658 AA; 75017 MW; FD4B07BA83FC2740 CRC64;
MSLTSLNLEK YRKDQNNIHT HIHVHIVHRQ TVLPPPTHSP HPSPSMSVPL KTTNRSPLRE
TDANLKPQSA LGPRACPESH ATAAAAPSTK KRALDRLEHS LVKQQRVKRT RSIEGAVLLN
KPAGKPVAAR AQALQPKELV EWQNNWLRIL KRDTRIFFDV REDKKSGRLR HKLEEKRELL
VAGFELLGAE ISPFYDNRTT IVITTRSAED IAQEMDSNDI LVRARKNSIK VWGFEKAFRF
LSNLNVEIDT FRLEDPQFKK LDSPDITAQT HLARASKTGT LSTLLKNEKI FGSNDRDPRT
RRDDIHYFKY PHVYMYDLWQ TWAPIITLEW KPQELADVEH LPYPTLKMGT FGRCPFIGDK
LCDERSEKRV IKRYSRDQEN RKHATELHIW YQHHAQPDFH NMHVPTMTIP HICNDSRYMY
LQFPPHFEDL FGKINDDKSV MEEEALSTST HSDNTAAADA EKHAATWREP ATPQLKHAKL
ARQETEEFPD DLCNSFKKHS QVPFEIKASG VHQSNDVATS FGNGLGPTKA SVTSKKIKTL
NRLVVDRKLV SKTPSQANKT RHSSHKDVPA GSNLKISSNA SSKLAPPAQV PAPAPTKMRA
AKPAKRPVVR NPGYCENCRV KYEALEEHIL SDKHLAFAEN GLNFECIDSL IDKLKFQF
//
