ID K5BFJ1_MYCHD Unreviewed; 268 AA.
AC K5BFJ1;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 18-JUN-2025, entry version 42.
DE SubName: Full=2-dehydropantoate 2-reductase family protein {ECO:0000313|EMBL:EKF23942.1};
DE EC=1.1.1.- {ECO:0000313|EMBL:EKF23942.1};
GN ORFNames=C731_2044 {ECO:0000313|EMBL:EKF23942.1};
OS Mycolicibacterium hassiacum (strain DSM 44199 / CIP 105218 / JCM 12690 /
OS 3849) (Mycobacterium hassiacum).
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Mycobacteriaceae; Mycolicibacterium.
OX NCBI_TaxID=1122247 {ECO:0000313|EMBL:EKF23942.1, ECO:0000313|Proteomes:UP000006265};
RN [1] {ECO:0000313|EMBL:EKF23942.1, ECO:0000313|Proteomes:UP000006265}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44199 / CIP 105218 / JCM 12690 / 3849
RC {ECO:0000313|Proteomes:UP000006265};
RX PubMed=23209251; DOI=10.1128/JB.01880-12;
RA Tiago I., Maranha A., Mendes V., Alarico S., Moynihan P.J., Clarke A.J.,
RA Macedo-Ribeiro S., Pereira P.J., Empadinhas N.;
RT "Genome sequence of Mycobacterium hassiacum DSM 44199, a rare source of
RT heat-stable mycobacterial proteins.";
RL J. Bacteriol. 194:7010-7011(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKF23942.1}.
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DR EMBL; AMRA01000052; EKF23942.1; -; Genomic_DNA.
DR AlphaFoldDB; K5BFJ1; -.
DR STRING; 1122247.GCA_000379865_00059; -.
DR PATRIC; fig|1122247.3.peg.1965; -.
DR eggNOG; COG1893; Bacteria.
DR Proteomes; UP000006265; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1040.10; N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR051402; KPR-Related.
DR InterPro; IPR013332; KPR_N.
DR NCBIfam; NF005091; PRK06522.2-2; 1.
DR NCBIfam; NF009541; PRK12921.1-1; 1.
DR PANTHER; PTHR21708:SF26; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:EKF23942.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006265}.
FT DOMAIN 26..117
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 143..262
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 268 AA; 28609 MW; D4119FBEED72BBED CRC64;
MTLCGRTPRA SIEVRPDDGP PILLPGPVHT DPADVDGPVD VVLLAVKDTQ NRQAAAWLER
LCDERTVVCA LQNGVEQIDR VGPLCRGAQV VPAAIWISAE PTAEGWVRVR TGTRLVLPVG
PAAERIAELF DGTAVRVELD PDFVSAAWHK LLVNAVVGLM VLAGRRAGMF RRDDVAELGR
RYLTECLAVA RADGARLGEE VVDQIIDMLR ASPPDITTSM LTDREAGRAL EWDIRNGVIA
RKAAAYGLPA PISAVLVPLL AAASDGPG
//
