ID K6DE86_9BACI Unreviewed; 570 AA.
AC K6DE86;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 18-JUN-2025, entry version 34.
DE RecName: Full=Rqc2 homolog RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
DE Short=RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN Name=rqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN ORFNames=BABA_16532 {ECO:0000313|EMBL:EKN66373.1};
OS Neobacillus bataviensis LMG 21833.
OC Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae;
OC Neobacillus.
OX NCBI_TaxID=1117379 {ECO:0000313|EMBL:EKN66373.1, ECO:0000313|Proteomes:UP000006316};
RN [1] {ECO:0000313|EMBL:EKN66373.1, ECO:0000313|Proteomes:UP000006316}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 21833T {ECO:0000313|Proteomes:UP000006316};
RX PubMed=23087684;
RA Heylen K., Keltjens J.;
RT "Redundancy and modularity in membrane-associated dissimilatory nitrate
RT reduction in Bacillus.";
RL Front. Microbiol. 3:371-371(2012).
CC -!- FUNCTION: Key component of the ribosome quality control system (RQC), a
CC ribosome-associated complex that mediates the extraction of
CC incompletely synthesized nascent chains from stalled ribosomes and
CC their subsequent degradation. RqcH recruits Ala-charged tRNA, and with
CC RqcP directs the elongation of stalled nascent chains on 50S ribosomal
CC subunits, leading to non-templated C-terminal alanine extensions (Ala
CC tail). The Ala tail promotes nascent chain degradation. May add between
CC 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.
CC {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SUBUNIT: Associates with stalled 50S ribosomal subunits. Binds to RqcP.
CC {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SIMILARITY: Belongs to the NEMF family. {ECO:0000256|HAMAP-
CC Rule:MF_00844}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKN66373.1}.
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DR EMBL; AJLS01000118; EKN66373.1; -; Genomic_DNA.
DR RefSeq; WP_007086302.1; NZ_AJLS01000118.1.
DR AlphaFoldDB; K6DE86; -.
DR STRING; 1117379.BABA_16532; -.
DR PATRIC; fig|1117379.3.peg.3434; -.
DR eggNOG; COG1293; Bacteria.
DR OrthoDB; 9766163at2; -.
DR Proteomes; UP000006316; Unassembled WGS sequence.
DR GO; GO:1990112; C:RQC complex; IEA:TreeGrafter.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProtKB-UniRule.
DR FunFam; 2.30.310.10:FF:000004; Fibronectin-binding protein A; 1.
DR Gene3D; 1.10.8.50; -; 1.
DR Gene3D; 3.40.970.40; fibrinogen binding protein from staphylococcus aureus domain like; 1.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR HAMAP; MF_00844_B; RqcH_B; 1.
DR InterPro; IPR051608; RQC_Subunit_NEMF.
DR InterPro; IPR043682; RqcH_bacterial.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF18297; NFACT-R_2; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 3: Inferred from homology;
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_00844}; Reference proteome {ECO:0000313|Proteomes:UP000006316};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00844};
KW rRNA-binding {ECO:0000256|ARBA:ARBA00022730, ECO:0000256|HAMAP-
KW Rule:MF_00844};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|HAMAP-
KW Rule:MF_00844}.
SQ SEQUENCE 570 AA; 64848 MW; A76A4FEDCD127C6D CRC64;
MSFDGLFTKA MVDELVRSLK GGRINKVHQP YKNEVILTIR ANGVNQKLLL SAHPSYARVQ
LTNESYDNPS EPPMFCMLLR KHIEGHILED LYQVENDRMI IFEIKGRNEI GDISNKQLII
EIMGRHSNIV IVDKTRNVIL DSIKHVSFAV NSHRAILPGQ PYIFPPAQNK INPYEAVEED
VVKTVDFIGG KLDRQLVEHF AGTSPLFAKE VIFQSGLANR TTVPGTFIRL IKKIADGDIS
PSIISANGKD SFYLFPLEHL QGEIKTFPTL SELLDRFYFG KAERDRVKQQ GNDIERFISN
EKDKNEKKIR KLEDTLKEAE RAEQFQRYGE LLTANLYSAK KGMKEIEVLD YYDELGGTIV
IPLDPRKTPS ENAQKYFSKY QKAKNAVAVV VEQIEKAHLE VVYFDNLLQQ VLAASPKDIQ
EIREELIDGG YIRERKKRSG KKTQNIKPVL DHFIASDGTD IIVGKNNKQN DYLTNKLAAR
DEIWLHTKDI PGSHVVIRSK EPSDETIKEA AVLAAYYSKA RNSSSVPVDF TKVRYVKKPS
GAKPGFVIYD NQQTVYITPD EEIVLKLKKK
//
