UniProt: K6UEQ4

Database: UniProt
Entry: K6UEQ4_PLACD

LinkDB:  K6UEQ4_PLACD 
Original site:  K6UEQ4_PLACD

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Ontology (7)   
   GO (7)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (11)   
   InterPro (6)   
   Pfam (2)   
   PROSITE (2)   
   SMART (1)   
Literature (1)   
   PubMed (1)   
All databases (23)   

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ID   K6UEQ4_PLACD            Unreviewed;      1421 AA.
AC   K6UEQ4;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   08-OCT-2025, entry version 54.
DE   SubName: Full=NUDIX hydrolase {ECO:0000313|EMBL:GAB68756.1};
GN   ORFNames=PCYB_141840 {ECO:0000313|EMBL:GAB68756.1};
OS   Plasmodium cynomolgi (strain B).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX   NCBI_TaxID=1120755 {ECO:0000313|EMBL:GAB68756.1, ECO:0000313|Proteomes:UP000006319};
RN   [1] {ECO:0000313|EMBL:GAB68756.1, ECO:0000313|Proteomes:UP000006319}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B {ECO:0000313|EMBL:GAB68756.1,
RC   ECO:0000313|Proteomes:UP000006319};
RX   PubMed=22863735; DOI=10.1038/ng.2375;
RA   Tachibana S., Sullivan S.A., Kawai S., Nakamura S., Kim H.R., Goto N.,
RA   Arisue N., Palacpac N.M.Q., Honma H., Yagi M., Tougan T., Katakai Y.,
RA   Kaneko O., Mita T., Kita K., Yasutomi Y., Sutton P.L., Shakhbatyan R.,
RA   Horii T., Yasunaga T., Barnwell J.W., Escalante A.A., Carlton J.M.,
RA   Tanabe K.;
RT   "Plasmodium cynomolgi genome sequences provide insight into Plasmodium
RT   vivax and the monkey malaria clade.";
RL   Nat. Genet. 44:1051-1055(2012).
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the Nudix hydrolase family. DCP2 subfamily.
CC       {ECO:0000256|ARBA:ARBA00005279}.
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DR   EMBL; DF157106; GAB68756.1; -; Genomic_DNA.
DR   RefSeq; XP_004224703.1; XM_004224655.1.
DR   GeneID; 14695134; -.
DR   KEGG; pcy:PCYB_141840; -.
DR   VEuPathDB; PlasmoDB:PCYB_141840; -.
DR   eggNOG; KOG2937; Eukaryota.
DR   OMA; FNEMEMM; -.
DR   OrthoDB; 18996at2759; -.
DR   PhylomeDB; K6UEQ4; -.
DR   Proteomes; UP000006319; Chromosome 14.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0140933; F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity; IEA:InterPro.
DR   GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR   CDD; cd03672; NUDIX_Dcp2p_Nudt20; 1.
DR   FunFam; 3.90.79.10:FF:000045; mRNA-decapping enzyme 2; 1.
DR   Gene3D; 1.10.10.1050; Dcp2, box A domain; 1.
DR   Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR   InterPro; IPR007722; DCP2_BoxA.
DR   InterPro; IPR036189; DCP2_BoxA_sf.
DR   InterPro; IPR044099; Dcp2_NUDIX.
DR   InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR   InterPro; IPR020084; NUDIX_hydrolase_CS.
DR   InterPro; IPR000086; NUDIX_hydrolase_dom.
DR   PANTHER; PTHR23114; M7GPPPN-MRNA HYDROLASE; 1.
DR   PANTHER; PTHR23114:SF17; M7GPPPN-MRNA HYDROLASE; 1.
DR   Pfam; PF05026; DCP2; 1.
DR   Pfam; PF00293; NUDIX; 1.
DR   SMART; SM01125; DCP2; 1.
DR   SUPFAM; SSF140586; Dcp2 domain-like; 1.
DR   SUPFAM; SSF55811; Nudix; 1.
DR   PROSITE; PS51462; NUDIX; 1.
DR   PROSITE; PS00893; NUDIX_BOX; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:GAB68756.1};
KW   Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006319};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT   DOMAIN          134..263
FT                   /note="Nudix hydrolase"
FT                   /evidence="ECO:0000259|PROSITE:PS51462"
FT   REGION          372..414
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          598..668
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          826..874
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1284..1314
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1336..1355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        601..636
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        642..656
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        861..874
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1296..1306
FT                   /note="Low complexity"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1346..1355
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1421 AA;  159623 MW;  6629971793B4FA73 CRC64;
     MNLIKGAKNK PQKHSQNKYV NNNTKCKKIF SAHRIKQLAK DKKLLDDALL DCYGRFIALL
     PEFLLKDHVH LYFQIQEAYW WYDDMWQEKY PDKLPKLSLK TFGYLICDDC PILKKYVPPS
     AHEKFSLNWR RYCRTIPLRG AILLNHNLKK CLLVKGWSTD SWSFPKGKVD ELEEDSVCAC
     REIYEEIGID IFPYIDEQVF IETHIEDQPI KLFIIPGVKE DTKFQPKTRK EIGAIRWFEI
     EKLLEHINLK NKKSILFEIK WIEVLRRSVH AKDLKGGNSF ISGSIQAYKY QISGVDEAVI
     KKLQTVNLNS KEIINIGLFK SDDDLEEYDD ENLNENVNEN DKLLPKDVDE EMVSKQISTS
     YANYNSAIKV PGVDKNRGSF TNEEGVKNSS TSSSVSNRKM DKRSLGPNTK QNSTNYYNQE
     MVSIRGEGTV GQGLPLYDDM NCNDSRHSLD PMLEEGAYVE ESTYSRMEKE LMGNKKVYEH
     VDDAIVPLRR KDILLSSSAH YPDPAILGEV LNENNYSSDV GNNYKNNAMS GTYNTISTNS
     SCTKKMSKEV KKNDSRGNVA HKDLHAVESY PSAVSEVNSS AVKIPPKQNS LMVNHSENKK
     NSVSINSSGS GNGSSNNNNY NNNNNYNNSK NNYNNNMAYH GPSSSSAYKK TSNAHGNNYG
     KHYGENDPAG AKGYRYSLNK MRMGGHLSAL RLKEVGLRSF DDQDMDKRKN FHLQVYGNKD
     KFNCDKKEIQ NRYKKLSLKN PYHSLDDASV YYVPTKNKTL DACNDKTFGE NHTNGWSAED
     MFKLNEEKFG IHSTYNIEEY TTPLVYKEEK ISRYNKSAKV KEGINPHLVG SSNKQGGGYN
     IKISGPAEGG SPVLGRGIYG SSSSNNNDRN ENNLVSRSKG EFQNNEGKGN PIHSLNPNAY
     INVNALLARR MKMTQSGNPL LLNDKSSKKS VSCVSSNMSD SSREIGLVKS SNASVNFING
     CYVHHERNGD ADPRTTSQVD IHDSSHAHLL NGINGVSGMN SVSTANGTNG AGKNHVSKNH
     VSKNHVSKNR AGKNPSVNFN QAVSPMEERR SNVSVDVIRN EMLRKYKLKE GYGVMQRGSA
     NQKEVNNFVD LHNRSIGYTN MSADKNYKTE PQMNSSGNTP VSNEYMLNAT NRNNKMNIIS
     GDVNYKNRNA CYDVSYMKTG KDNNNYANKS NVGEYLNESI LGLTNDGMSG EGIHEYRSVQ
     SRSSLGGSSN GKNNMLIQGG LSVNREVIDK REYSHLDGEG RMGLYQINEM GIAASKKASQ
     GSNNSSSHSN EPGKYLLNLI KGTGKSGVES DPNLTNNNRN NASRASVLSG SNAKPLSEKE
     ILSKFYSNEA GNHAFTKKVN SARSSTGDKK NSINNRERHD NYRNVIPKDN LNMQKNRNRM
     SAEHLTYDGA GRRDAQEESN FNEMEMMEKL SKHLNSYNPF E
//

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