ID K7F896_PELSI Unreviewed; 817 AA.
AC K7F896;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 18-JUN-2025, entry version 71.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN Name=RNF19A {ECO:0000313|Ensembl:ENSPSIP00000004256.1};
OS Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC Trionychidae; Pelodiscus.
OX NCBI_TaxID=13735 {ECO:0000313|Ensembl:ENSPSIP00000004256.1, ECO:0000313|Proteomes:UP000007267};
RN [1] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RG Soft-shell Turtle Genome Consortium;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Daiwa-1 {ECO:0000313|Proteomes:UP000007267};
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
RN [3] {ECO:0000313|Ensembl:ENSPSIP00000004256.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the RBR family. RNF19 subfamily.
CC {ECO:0000256|ARBA:ARBA00061087}.
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DR EMBL; AGCU01082058; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01082059; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01082060; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01082061; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01082062; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01082063; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01082064; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01082065; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01082066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGCU01082067; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006122481.1; XM_006122419.2.
DR AlphaFoldDB; K7F896; -.
DR STRING; 13735.ENSPSIP00000004256; -.
DR Ensembl; ENSPSIT00000004279.1; ENSPSIP00000004256.1; ENSPSIG00000004011.1.
DR GeneID; 102461157; -.
DR KEGG; pss:102461157; -.
DR CTD; 25897; -.
DR eggNOG; KOG1815; Eukaryota.
DR GeneTree; ENSGT00940000158703; -.
DR HOGENOM; CLU_016793_1_0_1; -.
DR OMA; HQCSISL; -.
DR OrthoDB; 1431934at2759; -.
DR TreeFam; TF324777; -.
DR Proteomes; UP000007267; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd20362; BRcat_RBR_RNF19A; 1.
DR CDD; cd20355; Rcat_RBR_RNF19; 1.
DR CDD; cd16775; RING-HC_RBR_RNF19A; 1.
DR FunFam; 1.20.120.1750:FF:000001; RBR-type E3 ubiquitin transferase; 1.
DR FunFam; 2.20.25.20:FF:000004; RBR-type E3 ubiquitin transferase; 1.
DR FunFam; 3.30.40.10:FF:000052; RBR-type E3 ubiquitin transferase; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 2.20.25.20; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR Pfam; PF01485; IBR; 2.
DR SMART; SM00647; IBR; 2.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007267};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT TRANSMEM 343..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 110..333
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 114..162
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 604..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 682..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..642
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..665
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..698
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 817 AA; 88187 MW; 49945281D560C0DA CRC64;
MLTFNILLMN VLDMSLHRQM GSDRDLQSSA SSVSLPSVKK APKKRRISLA SIFRRKKDTK
RKSRDLNGGV DGIASIESIH SEMCTDKNSI FSTYTSSDSG TTSISKPSGD FMECPLCLLR
HSKDRFPEIM TCHHRSCVDC LRQYLRIEIS ESRVNISCPE CSERFNPHDI RLILNDDILM
EKYEEFMLRR WLVADPDCRW CPAPDCGYAV IAFGCASCPK LTCGREGCGT EFCYHCKQIW
HPNQTCDAAR QERAHSLRLR TIRSSSISYS QESGAAADDI KPCPRCAAYI IKMNDGSCNH
MTCAVCGCEF CWLCMKEISD LHYLSPSGCT FWGKKPWSRK KKILWQLGTL VGAPVGIALI
AGIAIPAMII GIPVYVGRKI HNRYEGKDIS KHKRNLAIAG GVTLSVIVSP VVAAVTVGIG
VPIMLAYVYG VVPISLCRSG GCGVSAGNGK GVRIEFDDEN DINVGGTNAA VDTTSVAEAR
NNPSIGEGSV GGLTGSLSAS GSHMDRIGAI RDNLSETAST MALAGASITG SLSGSAMVSC
FNRLEVQADV QKERYSLSGE SGTVSLGTVS DNASTKAMAG SILNSYIPLD REGNSMEVQV
DIESKPAKFR HNSGSSSVDD GSAPGRSNAG CSSSCLPESK SSATKWSKET TAGKKCKGKL
RKKSSMKINE TREDMDAQLL EQQSTNSSEF DSPSLSDSIP SVADSHSSHF SEFSCSDMES
MKTSCSHGSN DYHTRFTTVS VLPEVENDRL ENSPHQSGIP VLAPPAPSTE VPQLSYITEE
CVNNGTSTDV GVGLGETLKE TNNNHAVELN TALQTEI
//
