ID K9B0S6_9MICO Unreviewed; 615 AA.
AC K9B0S6;
DT 06-FEB-2013, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2013, sequence version 1.
DT 28-JAN-2026, entry version 53.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=C272_05744 {ECO:0000313|EMBL:EKU48387.1};
OS Brevibacterium casei S18.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Micrococcales;
OC Brevibacteriaceae; Brevibacterium.
OX NCBI_TaxID=1229781 {ECO:0000313|EMBL:EKU48387.1, ECO:0000313|Proteomes:UP000009879};
RN [1] {ECO:0000313|EMBL:EKU48387.1, ECO:0000313|Proteomes:UP000009879}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S18 {ECO:0000313|EMBL:EKU48387.1,
RC ECO:0000313|Proteomes:UP000009879};
RA Sharma R., Singh A., Jangir P.K.;
RT "Genome Sequence of Brevibacterium casei S18.";
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKU48387.1}.
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DR EMBL; AMSP01000003; EKU48387.1; -; Genomic_DNA.
DR RefSeq; WP_009376752.1; NZ_AMSP01000003.1.
DR AlphaFoldDB; K9B0S6; -.
DR PATRIC; fig|1229781.4.peg.1154; -.
DR eggNOG; COG3276; Bacteria.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000009879; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:EKU48387.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000009879}.
FT DOMAIN 1..170
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 615 AA; 64960 MW; 378CCF2DCEB78C8B CRC64;
MFVVATAGHV DHGKSTLVKA LTGMEPDRWE EERRRGLTID LGFAWTTLPS GRELAFVDVP
GHERFLANML AGVGPAPIVC FVIAADKGWQ AQSSDHRDAI AALGIDRGLV VVTRADLAPD
TVTETEAQVR AELRGTTLAD APIVTVSATT GQGMDELIAR LDEVTAAAPA PDADARVRLW
IDRAFSITGA GTVVTGTLTA GTLRAGDRVR VVGESVDLVT GIRGMQSRES SAEVVTPAAR
VAVNVRDVPV DDIHRGDALI TPDAWPIVEV LDVRRTMGEA LDDGVHELML HIGTAAVPVR
LRPFDAEHAR LTLERPLPLQ LGDRMVLRNP GSRNVFAGVV VLDVDPPELG RRGDGARRAA
ALASRPVTGD VLAEVARRGA VERVVLVRFG LTVPEALPSG VEALGAWLVH APTLQAWVTA
AKEVVAKQLA AQPMAPGVPV KAVVEALRRV DPPLPSAGAQ PAASPGSGTG IGALVAEVIR
RAGLEAADGV VRPPGHRADL GPAEAGVAKV EQRLKANPFD APEADDLRAL CLGARELAVA
EKAGRVLRLG DGVVVSPRTP AQAMRLLAGL DQPFTTSQAR RALGTTRRVV IPLLEHLDSR
GWTRRLDGSH REVVR
//
