ID L1KM34_9ACTN Unreviewed; 323 AA.
AC L1KM34;
DT 06-MAR-2013, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 1.
DT 18-JUN-2025, entry version 35.
DE SubName: Full=2-dehydropantoate 2-reductase {ECO:0000313|EMBL:EKX61851.1};
DE EC=1.1.1.169 {ECO:0000313|EMBL:EKX61851.1};
GN ORFNames=STRIP9103_08310 {ECO:0000313|EMBL:EKX61851.1};
OS Streptomyces ipomoeae 91-03.
OC Bacteria; Bacillati; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=698759 {ECO:0000313|EMBL:EKX61851.1, ECO:0000313|Proteomes:UP000010411};
RN [1] {ECO:0000313|EMBL:EKX61851.1, ECO:0000313|Proteomes:UP000010411}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91-03 {ECO:0000313|EMBL:EKX61851.1,
RC ECO:0000313|Proteomes:UP000010411};
RA Huguet-Tapia J.C., Durkin A.S., Pettis G.S., Badger J.H.;
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC {ECO:0000256|ARBA:ARBA00007870}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKX61851.1}.
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DR EMBL; AEJC01000558; EKX61851.1; -; Genomic_DNA.
DR RefSeq; WP_009331694.1; NZ_AEJC01000558.1.
DR AlphaFoldDB; L1KM34; -.
DR PATRIC; fig|698759.3.peg.7447; -.
DR OrthoDB; 9796561at2; -.
DR Proteomes; UP000010411; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:TreeGrafter.
DR GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:UniProtKB-EC.
DR FunFam; 1.10.1040.10:FF:000017; 2-dehydropantoate 2-reductase; 1.
DR FunFam; 3.40.50.720:FF:000307; 2-dehydropantoate 2-reductase; 1.
DR Gene3D; 1.10.1040.10; N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR051402; KPR-Related.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR NCBIfam; NF005089; PRK06522.1-4; 1.
DR PANTHER; PTHR21708:SF45; 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EKX61851.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010411}.
FT DOMAIN 3..104
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 196..314
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
SQ SEQUENCE 323 AA; 34223 MW; 6E88320295631B0D CRC64;
MKVAVLGAGA IGAYVGAALH RGGADVHLVA RGPHLAAMRR DGVRILSPRG DFTARAHATD
DPAEIGPVDF VFLGLKANSY AACGPLIEPL LHDTTAVIAA QNGIPWWYFH RHGGPHDGHR
VESVDPDGAV SAVLAPERAI GCVVYAATEL EGPGVVRHLE GTRFSIGEPD RTVSTRCRAF
SEAMRAGGLK CPVEPDIRGD IWIKLLGNIS FNPISALARA TMRQMCLHGG TRKVIETMMA
ETLAVAEALG CEVGVSIERR MAGAERVGDH RTSTLQDLER GKPLELDVLL AAVVELADIT
GVDVPTLRTV HAISDLLALR SAA
//
