ID L8GSN9_ACACF Unreviewed; 398 AA.
AC L8GSN9;
DT 03-APR-2013, integrated into UniProtKB/TrEMBL.
DT 03-APR-2013, sequence version 1.
DT 08-OCT-2025, entry version 33.
DE SubName: Full=Adhesion regulating molecule region protein, putative {ECO:0000313|EMBL:ELR15116.1};
GN ORFNames=ACA1_215980 {ECO:0000313|EMBL:ELR15116.1};
OS Acanthamoeba castellanii (strain ATCC 30010 / Neff).
OC Eukaryota; Amoebozoa; Discosea; Longamoebia; Centramoebida;
OC Acanthamoebidae; Acanthamoeba.
OX NCBI_TaxID=1257118 {ECO:0000313|EMBL:ELR15116.1, ECO:0000313|Proteomes:UP000011083};
RN [1] {ECO:0000313|EMBL:ELR15116.1, ECO:0000313|Proteomes:UP000011083}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Neff {ECO:0000313|EMBL:ELR15116.1,
RC ECO:0000313|Proteomes:UP000011083};
RX PubMed=23375108; DOI=10.1186/gb-2013-14-2-r11;
RA Clarke M., Lohan A.J., Liu B., Lagkouvardos I., Roy S., Zafar N.,
RA Bertelli C., Schilde C., Kianianmomeni A., Burglin T.R., Frech C.,
RA Turcotte B., Kopec K.O., Synnott J.M., Choo C., Paponov I., Finkler A.,
RA Soon Heng Tan C., Hutchins A.P., Weinmeier T., Rattei T., Chu J.S.,
RA Gimenez G., Irimia M., Rigden D.J., Fitzpatrick D.A., Lorenzo-Morales J.,
RA Bateman A., Chiu C.H., Tang P., Hegemann P., Fromm H., Raoult D., Greub G.,
RA Miranda-Saavedra D., Chen N., Nash P., Ginger M.L., Horn M., Schaap P.,
RA Caler L., Loftus B.;
RT "Genome of Acanthamoeba castellanii highlights extensive lateral gene
RT transfer and early evolution of tyrosine kinase signaling.";
RL Genome Biol. 14:R11-R11(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KB008036; ELR15116.1; -; Genomic_DNA.
DR RefSeq; XP_004337129.1; XM_004337081.1.
DR AlphaFoldDB; L8GSN9; -.
DR STRING; 1257118.L8GSN9; -.
DR GeneID; 14915644; -.
DR KEGG; acan:ACA1_215980; -.
DR VEuPathDB; AmoebaDB:ACA1_215980; -.
DR OMA; RSPQFMQ; -.
DR OrthoDB; 340431at2759; -.
DR Proteomes; UP000011083; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:TreeGrafter.
DR GO; GO:0061133; F:endopeptidase activator activity; IEA:TreeGrafter.
DR GO; GO:0070628; F:proteasome binding; IEA:TreeGrafter.
DR CDD; cd13314; PH_Rpn13; 1.
DR FunFam; 2.30.29.70:FF:000001; Proteasomal ubiquitin receptor ADRM1; 1.
DR Gene3D; 1.10.2020.20; -; 1.
DR Gene3D; 2.30.29.70; Proteasomal ubiquitin receptor Rpn13/ADRM1; 1.
DR InterPro; IPR044867; DEUBAD_dom.
DR InterPro; IPR006773; Rpn13/ADRM1.
DR InterPro; IPR044868; Rpn13/ADRM1_Pru.
DR InterPro; IPR038633; Rpn13/ADRM1_Pru_sf.
DR InterPro; IPR032368; RPN13_DEUBAD.
DR InterPro; IPR038108; RPN13_DEUBAD_sf.
DR PANTHER; PTHR12225; ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN; 1.
DR PANTHER; PTHR12225:SF0; PROTEASOMAL UBIQUITIN RECEPTOR ADRM1; 1.
DR Pfam; PF04683; Rpn13_ADRM1_Pru; 1.
DR Pfam; PF16550; RPN13_C; 1.
DR PROSITE; PS51916; DEUBAD; 1.
DR PROSITE; PS51917; PRU; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteasome {ECO:0000256|ARBA:ARBA00022942};
KW Reference proteome {ECO:0000313|Proteomes:UP000011083}.
FT DOMAIN 29..143
FT /note="Pru"
FT /evidence="ECO:0000259|PROSITE:PS51917"
FT DOMAIN 257..362
FT /note="DEUBAD"
FT /evidence="ECO:0000259|PROSITE:PS51916"
FT REGION 180..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..232
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..368
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 398 AA; 41638 MW; A3F1CBAB363979EA CRC64;
MKVQSNFKYL RNVVGTRIYT RILNPCMFGP QKPLVEFKAG KMLIRGKMVI PDKRKGKIEL
AQSPDDQLMH FRWKDRSTGQ VETDLIIFPD EAVFKKVKQC TTGRVFLLEW KSTERRLFFW
MQEPSDEKDA ELCEKVNKAL NSPPAAEGGE AGAGGVPGLA GMSQEQLLAM MGMGGLGGMG
GGGGARRGSA RGAAAASAPP SGAQPAAGGA RSAAPTPSTP APTTTARSTD ASIGEQQLQN
ILRELGAAQG GGAGAAGGQA PEDVDLSSVM TSEALLPLLS NPAVAEQLLP YLPEGQRNPE
ELRELVRSPQ FHQALQAFNS ALQSGALADV LPALGLPASA AGGGVQDFLR ALQEQSQRQS
GGQQQQQGGS QGGNEPAGGE KKDDKDGSSG KDGDMDTS
//
