ID M1E4A1_9BACT Unreviewed; 626 AA.
AC M1E4A1;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 28-JAN-2026, entry version 59.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=Thena_0233 {ECO:0000313|EMBL:AEE13882.1};
OS Thermodesulfobium narugense DSM 14796.
OC Bacteria; Pseudomonadati; Thermodesulfobiota; Thermodesulfobiia;
OC Thermodesulfobiales; Thermodesulfobiaceae; Thermodesulfobium.
OX NCBI_TaxID=747365 {ECO:0000313|EMBL:AEE13882.1, ECO:0000313|Proteomes:UP000011765};
RN [1] {ECO:0000313|EMBL:AEE13882.1, ECO:0000313|Proteomes:UP000011765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14796 {ECO:0000313|EMBL:AEE13882.1,
RC ECO:0000313|Proteomes:UP000011765};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Han J., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L.,
RA Kyrpides N., Mavromatis K., Pagani I., Ivanova N., Ovchinnikova G.,
RA Zhang X., Saunders L., Detter J.C., Tapia R., Han C., Land M., Hauser L.,
RA Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Spring S.,
RA Schroeder M., Brambilla E., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Thermodesulfobium narugense DSM 14796.";
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP002690; AEE13882.1; -; Genomic_DNA.
DR RefSeq; WP_013755612.1; NC_015499.1.
DR AlphaFoldDB; M1E4A1; -.
DR STRING; 747365.Thena_0233; -.
DR KEGG; tnr:Thena_0233; -.
DR eggNOG; COG3276; Bacteria.
DR HOGENOM; CLU_023030_3_0_9; -.
DR OrthoDB; 9804504at2; -.
DR Proteomes; UP000011765; Chromosome.
DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:AEE13882.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000011765}.
FT DOMAIN 1..172
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 626 AA; 71359 MW; 2BF4B8692185EF40 CRC64;
MRDFILGTAG HIDHGKTELI ARLTGRRTER FPEERIRGMT IDIGFSSLEL PCGKVLGIVD
VPGHERFIDN MLVGSAGVDL ALLVVAADEG IKEQTREHFE ILKLLEVKDG LIVITKKDLV
DEELLEYLKE EIKDFVKGSF LENNPIICAS SVTGEGLEEI LEVLNEKVEL LYSKEYDDNE
KPFRLFIDRK FKIKGFGLVV TGTVYSGSVR VGDSLEITPF KDAIRVKNLE SHFNKVQEGH
TGMRLAVNIN TTLDENFITR GKVLVEKNYY KESTKFVGFL NVLDSYENLK NNKRVHLYVG
SSSSVCRLSF EGSPSEGKMS YIVKLSCQNP VCAVRGDKFI LRDPSAKKTL GGGIILDNEQ
IKLKDLSKYL NDKPIIDKKD LSSNIVQVVK RKGIMELFDL AKKVNYKAEY VRKFISETTL
NVFENEGKVY LFSSDYQKDL LERLENIIFE IESKNPFQTQ ISKEEILKKL DSPIAQNIID
KYAKKKGYLV DKTYLLKERV SDEVLTMVDE VEKDIKNLGF FVLPLDELGL KYKDKKAFNS
AIATLKRSQK IFQVSISPEI YIHFSNLEKL VNLLKEFFQK SNELSVSDFK DLTNTTRKFS
IPLLEFCDKM GFTKRIGNVR QKGKKL
//
