ID M2XG68_GALSU Unreviewed; 367 AA.
AC M2XG68;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 08-OCT-2025, entry version 49.
DE SubName: Full=mRNA-decapping enzyme subunit 2 {ECO:0000313|EMBL:EME29037.1};
GN ORFNames=Gasu_36050 {ECO:0000313|EMBL:EME29037.1};
OS Galdieria sulphuraria (Red alga).
OC Eukaryota; Rhodophyta; Bangiophyceae; Galdieriales; Galdieriaceae;
OC Galdieria.
OX NCBI_TaxID=130081 {ECO:0000313|EMBL:EME29037.1, ECO:0000313|Proteomes:UP000030680};
RN [1] {ECO:0000313|Proteomes:UP000030680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=074W {ECO:0000313|Proteomes:UP000030680};
RX PubMed=23471408; DOI=10.1126/science.1231707;
RA Schonknecht G., Chen W.H., Ternes C.M., Barbier G.G., Shrestha R.P.,
RA Stanke M., Brautigam A., Baker B.J., Banfield J.F., Garavito R.M., Carr K.,
RA Wilkerson C., Rensing S.A., Gagneul D., Dickenson N.E., Oesterhelt C.,
RA Lercher M.J., Weber A.P.;
RT "Gene transfer from bacteria and archaea facilitated evolution of an
RT extremophilic eukaryote.";
RL Science 339:1207-1210(2013).
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the Nudix hydrolase family. DCP2 subfamily.
CC {ECO:0000256|ARBA:ARBA00005279}.
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DR EMBL; KB454513; EME29037.1; -; Genomic_DNA.
DR RefSeq; XP_005705557.1; XM_005705500.1.
DR AlphaFoldDB; M2XG68; -.
DR SMR; M2XG68; -.
DR STRING; 130081.M2XG68; -.
DR GeneID; 17087865; -.
DR Gramene; EME29037; EME29037; Gasu_36050.
DR KEGG; gsl:Gasu_36050; -.
DR eggNOG; KOG2937; Eukaryota.
DR OMA; KLNMSAI; -.
DR OrthoDB; 18996at2759; -.
DR Proteomes; UP000030680; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0140933; F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity; IEA:InterPro.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IEA:InterPro.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR CDD; cd03672; NUDIX_Dcp2p_Nudt20; 1.
DR FunFam; 3.90.79.10:FF:000003; M7GpppN-mRNA hydrolase isoform 2; 1.
DR Gene3D; 1.10.10.1050; Dcp2, box A domain; 1.
DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR InterPro; IPR007722; DCP2_BoxA.
DR InterPro; IPR036189; DCP2_BoxA_sf.
DR InterPro; IPR044099; Dcp2_NUDIX.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR020084; NUDIX_hydrolase_CS.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR PANTHER; PTHR23114; M7GPPPN-MRNA HYDROLASE; 1.
DR PANTHER; PTHR23114:SF17; M7GPPPN-MRNA HYDROLASE; 1.
DR Pfam; PF05026; DCP2; 1.
DR Pfam; PF00293; NUDIX; 1.
DR SMART; SM01125; DCP2; 1.
DR SUPFAM; SSF140586; Dcp2 domain-like; 1.
DR SUPFAM; SSF55811; Nudix; 1.
DR PROSITE; PS51462; NUDIX; 1.
DR PROSITE; PS00893; NUDIX_BOX; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000030680};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 91..218
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS51462"
SQ SEQUENCE 367 AA; 42327 MW; C5FFA83DC7204400 CRC64;
MQNELSSVLI DLSSRFLLTL SQEDFENFER LFFAVEEAHW FYDDFFREKN SSLPKLSLRE
FAALLFEHSP LLDKYTKNVK HLLKNFQQYK NSIPTAGVAL LNSTLEKVLL VKGFRGKSWS
FPKGKVGKDE SYESCAVREA REEVGFDVSN QLYRENLLTS NWQGHESYIF IVPGIPDSTR
FETNTRKEIS EIKWHDIFSL PSSEDDSGGN ELHPKLKRSR FFSVLPFVKP LQSWVLSRNR
NLGMTRDSSG LEYPRTKASF SNVTSKRLSR REALSKQRVE TKSLKTNKKD LETFGVGKPF
SSWEEERNFL QACFDRSSQG TTMQPTEQAF LIDVNSRKGS GLSNFAFSRQ SIEAEWERLI
LGNVSQN
//
