ID M3XJM3_LATCH Unreviewed; 487 AA.
AC M3XJM3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 10-JUN-2026, entry version 62.
DE RecName: Full=Centrosomal protein 57kDa-like protein 1 {ECO:0000256|ARBA:ARBA00041218};
DE AltName: Full=Cep57-related protein {ECO:0000256|ARBA:ARBA00042578};
GN Name=CEP57L1 {ECO:0000313|Ensembl:ENSLACP00000022929.1};
OS Latimeria chalumnae (Coelacanth).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Coelacanthiformes; Coelacanthidae; Latimeria.
OX NCBI_TaxID=7897 {ECO:0000313|Ensembl:ENSLACP00000022929.1, ECO:0000313|Proteomes:UP000008672};
RN [1] {ECO:0000313|Ensembl:ENSLACP00000022929.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JAN-2026) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC -!- SIMILARITY: Belongs to the translokin family.
CC {ECO:0000256|ARBA:ARBA00008179}.
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DR EMBL; AFYH01040103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01040104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01040105; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01040106; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AFYH01040107; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3XJM3; -.
DR FunCoup; M3XJM3; 164.
DR Ensembl; ENSLACT00000025060.1; ENSLACP00000022929.1; ENSLACG00000017598.2.
DR eggNOG; ENOG502QTVF; Eukaryota.
DR GeneTree; ENSGT00530000063695; -.
DR InParanoid; M3XJM3; -.
DR OMA; LQTMQHY; -.
DR Proteomes; UP000008672; Unassembled WGS sequence.
DR Bgee; ENSLACG00000017598; Expressed in pectoral fin and 2 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR Gene3D; 1.20.58.90; -; 1.
DR InterPro; IPR051756; Centrosomal_MT-associated.
DR InterPro; IPR025913; Cep57_CLD.
DR InterPro; IPR024957; Cep57_MT-bd_dom.
DR PANTHER; PTHR19336:SF10; CENTROSOMAL PROTEIN CEP57L1; 1.
DR PANTHER; PTHR19336; UNCHARACTERIZED DUF1167; 1.
DR Pfam; PF14073; Cep57_CLD; 1.
DR Pfam; PF06657; Cep57_MT_bd; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000008672}.
FT DOMAIN 58..244
FT /note="Cep57 centrosome localisation"
FT /evidence="ECO:0000259|Pfam:PF14073"
FT DOMAIN 348..418
FT /note="Cep57 centrosome microtubule-binding"
FT /evidence="ECO:0000259|Pfam:PF06657"
FT REGION 244..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 431..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 56..154
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 181..229
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 253..262
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..443
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 487 AA; 55393 MW; A089541D42812EA0 CRC64;
MESSVHNRFL GSFYLPREKL SAFAFPTYKQ AESPTVDTGS ERLTGQTTGM RSASNSQALA
TALKTLQEKI HRLELERSKA ADNFKQLSSQ TTLYGKVLEH EKDLEYAGLT KQNNELSCQL
SAAKARCSIL EKQLEYMREM MENAEAEKNI LLEKQYKTFL KGCSDVSTSL QNEKSTNPVE
LHTKLEKLEN LERECLKLTT TQNATEDKIQ QLQQKLHEEE HQRKLIQDKA AQLQTGLEMN
RILLTSVSPQ KEPKKKIKKK QSSKQNASLK EETSQTRVSK KHAELPFVAG KSASPSHSLR
ANVQNVLYMM KHYRPQMCER KPRSCYHRVL RNKNIKQEVG RPVSACSTSS SVSFEGLSEL
LLALQDELGQ MSFEHQELVK QIHETKNTAV REDLERELDS LVKQMELKGD QISNLKKHQV
KVQTLKQKAQ QMKKKRTHAK SRGGKVNGVQ KQMVTPRQIH GKTPPGQKSK DFLLCRQCRA
KGVPGPV
//
