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Database: UniProt
Entry: P19946
LinkDB: P19946
Original site: P19946 
ID   RL15_BACSU              Reviewed;         146 AA.
AC   P19946;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   29-SEP-2021, entry version 131.
DE   RecName: Full=50S ribosomal protein L15 {ECO:0000255|HAMAP-Rule:MF_01341};
GN   Name=rplO {ECO:0000255|HAMAP-Rule:MF_01341}; OrderedLocusNames=BSU01350;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2113521; DOI=10.1093/oxfordjournals.jbchem.a123093;
RA   Nakamura K., Nakamura A., Takamatsu H., Yoshikawa H., Yamane K.;
RT   "Cloning and characterization of a Bacillus subtilis gene homologous to E.
RT   coli secY.";
RL   J. Biochem. 107:603-607(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2139212; DOI=10.1093/nar/18.6.1647;
RA   Yoshikawa H., Doi R.H.;
RT   "Sequence of the Bacillus subtilis spectinomycin resistance gene region.";
RL   Nucleic Acids Res. 18:1647-1647(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC   3610 / NRRL NRS-744 / VKM B-501;
RX   PubMed=8635744; DOI=10.1016/0378-1119(95)00757-1;
RA   Suh J.-W., Boylan S.A., Oh S.H., Price C.W.;
RT   "Genetic and transcriptional organization of the Bacillus subtilis spc-
RT   alpha region.";
RL   Gene 169:17-23(1996).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 94-146.
RC   STRAIN=168;
RX   PubMed=2110998; DOI=10.1111/j.1365-2958.1990.tb00597.x;
RA   Suh J.-W., Boylan S.A., Thomas S.M., Dolan K.M., Oliver D.B., Price C.W.;
RT   "Isolation of a secY homologue from Bacillus subtilis: evidence for a
RT   common protein export pathway in eubacteria.";
RL   Mol. Microbiol. 4:305-314(1990).
RN   [6] {ECO:0007744|PDB:6HA1, ECO:0007744|PDB:6HA8}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS) OF 1-146 WITH AND WITHOUT
RP   VIRGINIAMYCIN M.
RX   PubMed=30126986; DOI=10.1073/pnas.1808535115;
RA   Crowe-McAuliffe C., Graf M., Huter P., Takada H., Abdelshahid M.,
RA   Novacek J., Murina V., Atkinson G.C., Hauryliuk V., Wilson D.N.;
RT   "Structural basis for antibiotic resistance mediated by the Bacillus
RT   subtilis ABCF ATPase VmlR.";
RL   Proc. Natl. Acad. Sci. U.S.A. 115:8978-8983(2018).
CC   -!- FUNCTION: Binds to the 23S rRNA. {ECO:0000255|HAMAP-Rule:MF_01341}.
CC   -!- SUBUNIT: Part of the 50S ribosomal subunit.
CC       {ECO:0000269|PubMed:30126986}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL15 family.
CC       {ECO:0000255|HAMAP-Rule:MF_01341}.
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DR   EMBL; D00619; BAA00494.1; -; Genomic_DNA.
DR   EMBL; X51329; CAA35711.1; -; Genomic_DNA.
DR   EMBL; L47971; AAB06818.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB11911.1; -; Genomic_DNA.
DR   EMBL; M31102; AAB59117.1; -; Genomic_DNA.
DR   PIR; S12682; R5BSL5.
DR   RefSeq; NP_388016.1; NC_000964.3.
DR   RefSeq; WP_003225819.1; NZ_JNCM01000029.1.
DR   PDB; 3J3V; EM; 13.30 A; L=1-146.
DR   PDB; 3J3W; EM; 10.70 A; L=1-146.
DR   PDB; 3J9W; EM; 3.90 A; BO=1-146.
DR   PDB; 5NJT; EM; 3.80 A; e=1-146.
DR   PDB; 6HA1; EM; 3.10 A; L=1-146.
DR   PDB; 6HA8; EM; 3.50 A; L=1-146.
DR   PDB; 6HTQ; EM; 4.50 A; L=1-146.
DR   PDB; 6PPF; EM; 3.40 A; L=1-145.
DR   PDB; 6PPK; EM; 4.40 A; L=1-146.
DR   PDB; 6PVK; EM; 3.40 A; L=1-145.
DR   PDB; 6TNN; EM; 3.07 A; e=1-146.
DR   PDB; 6TPQ; EM; 3.07 A; e=1-146.
DR   PDB; 7AQC; EM; 2.99 A; L=1-146.
DR   PDB; 7AQD; EM; 3.10 A; L=1-146.
DR   PDB; 7AS8; EM; 2.90 A; P=1-146.
DR   PDB; 7AS9; EM; 3.50 A; P=1-146.
DR   PDBsum; 3J3V; -.
DR   PDBsum; 3J3W; -.
DR   PDBsum; 3J9W; -.
DR   PDBsum; 5NJT; -.
DR   PDBsum; 6HA1; -.
DR   PDBsum; 6HA8; -.
DR   PDBsum; 6HTQ; -.
DR   PDBsum; 6PPF; -.
DR   PDBsum; 6PPK; -.
DR   PDBsum; 6PVK; -.
DR   PDBsum; 6TNN; -.
DR   PDBsum; 6TPQ; -.
DR   PDBsum; 7AQC; -.
DR   PDBsum; 7AQD; -.
DR   PDBsum; 7AS8; -.
DR   PDBsum; 7AS9; -.
DR   SMR; P19946; -.
DR   STRING; 224308.BSU01350; -.
DR   jPOST; P19946; -.
DR   PaxDb; P19946; -.
DR   PRIDE; P19946; -.
DR   EnsemblBacteria; CAB11911; CAB11911; BSU_01350.
DR   GeneID; 50135124; -.
DR   GeneID; 64301973; -.
DR   GeneID; 935940; -.
DR   KEGG; bsu:BSU01350; -.
DR   PATRIC; fig|224308.179.peg.138; -.
DR   eggNOG; COG0200; Bacteria.
DR   InParanoid; P19946; -.
DR   OMA; FKNINRV; -.
DR   PhylomeDB; P19946; -.
DR   BioCyc; BSUB:BSU01350-MONOMER; -.
DR   PRO; PR:P19946; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01341; Ribosomal_L15; 1.
DR   InterPro; IPR036227; L18e/L15P_sf.
DR   InterPro; IPR030878; Ribosomal_L15.
DR   InterPro; IPR005749; Ribosomal_L15_bac-type.
DR   InterPro; IPR001196; Ribosomal_L15_CS.
DR   InterPro; IPR021131; Ribosomal_L18e/L15P.
DR   PANTHER; PTHR12934; PTHR12934; 1.
DR   Pfam; PF00828; Ribosomal_L27A; 1.
DR   SUPFAM; SSF52080; SSF52080; 1.
DR   TIGRFAMs; TIGR01071; rplO_bact; 1.
DR   PROSITE; PS00475; RIBOSOMAL_L15; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW   RNA-binding; rRNA-binding.
FT   CHAIN           1..146
FT                   /note="50S ribosomal protein L15"
FT                   /id="PRO_0000104674"
FT   REGION          1..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   HELIX           3..5
FT                   /evidence="ECO:0007829|PDB:6TPQ"
FT   TURN            10..12
FT                   /evidence="ECO:0007829|PDB:7AQC"
FT   STRAND          19..21
FT                   /evidence="ECO:0007829|PDB:6PVK"
FT   TURN            23..26
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   TURN            28..32
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   STRAND          35..37
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   TURN            38..40
FT                   /evidence="ECO:0007829|PDB:6TPQ"
FT   STRAND          41..43
FT                   /evidence="ECO:0007829|PDB:6TNN"
FT   STRAND          52..54
FT                   /evidence="ECO:0007829|PDB:6TNN"
FT   HELIX           57..60
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   STRAND          75..77
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   HELIX           81..84
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   STRAND          85..87
FT                   /evidence="ECO:0007829|PDB:7AQC"
FT   HELIX           93..99
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   STRAND          101..103
FT                   /evidence="ECO:0007829|PDB:6PPF"
FT   STRAND          109..111
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   STRAND          122..128
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   HELIX           130..139
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   STRAND          142..145
FT                   /evidence="ECO:0007829|PDB:7AS8"
SQ   SEQUENCE   146 AA;  15383 MW;  5DB07A902B266C11 CRC64;
     MKLHELKPSE GSRKTRNRVG RGIGSGNGKT AGKGHKGQNA RSGGGVRPGF EGGQMPLFQR
     LPKRGFTNIN RKEYAVVNLD KLNGFAEGTE VTPELLLETG VISKLNAGVK ILGNGKLEKK
     LTVKANKFSA SAKEAVEAAG GTAEVI
//
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