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Database: UniProt
Entry: P35774
LinkDB: P35774
Original site: P35774 
ID   SPIKE_ADE1P             Reviewed;         325 AA.
AC   P35774;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   02-JUN-2021, entry version 96.
DE   RecName: Full=Fiber protein;
DE            Short=SPIKE;
DE   AltName: Full=Protein IV;
GN   ORFNames=L5;
OS   Human adenovirus B serotype 11 (strain Slobiski) (HAdV-11) (Human
OS   adenovirus 11P (strain Slobiski)).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Rowavirales; Adenoviridae; Mastadenovirus; Human mastadenovirus B.
OX   NCBI_TaxID=343462;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8503168; DOI=10.1006/viro.1993.1284;
RA   Mei Y.-F., Wadell G.;
RT   "Hemagglutination properties and nucleotide sequence analysis of the fiber
RT   gene of adenovirus genome types 11p and 11a.";
RL   Virology 194:453-462(1993).
RN   [2]
RP   REVIEW.
RX   PubMed=16160140; DOI=10.1128/jvi.79.19.12125-12131.2005;
RA   Zhang Y., Bergelson J.M.;
RT   "Adenovirus receptors.";
RL   J. Virol. 79:12125-12131(2005).
CC   -!- FUNCTION: Forms spikes that protrude from each vertex of the
CC       icosahedral capsid. Interacts with host receptor CD46 to provide virion
CC       initial attachment to target cell. Fiber proteins are shed during virus
CC       entry, when virus is still at the cell surface.
CC   -!- SUBUNIT: Homotrimer. Interacts with host receptor CD46. Interacts (via
CC       N-terminal tail region) with pentons (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host nucleus {ECO:0000250}.
CC       Note=Anchored to the pentons, protrudes from the virion surface.
CC       {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- DOMAIN: The tail region anchors the fiber to penton base capsomers,
CC       whereas the shaft, built from several repeated motifs, allows the knob
CC       to protrude from the virion. {ECO:0000250}.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adenoviridae fiber family. {ECO:0000305}.
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DR   EMBL; AF532578; AAA42490.1; -; Genomic_DNA.
DR   PIR; D37476; D37476.
DR   PDB; 2O39; X-ray; 2.85 A; A/B=129-325.
DR   PDB; 3EXV; X-ray; 1.45 A; A=117-325.
DR   PDBsum; 2O39; -.
DR   PDBsum; 3EXV; -.
DR   SMR; P35774; -.
DR   EvolutionaryTrace; P35774; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0098671; P:adhesion receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.90.10; -; 1.
DR   InterPro; IPR000931; Adeno_fibre.
DR   InterPro; IPR000978; Adeno_fibre_knob.
DR   InterPro; IPR000939; Adenobir_fibre_prot_rpt/shaft.
DR   InterPro; IPR008982; Adenovirus_pIV-like_att.
DR   InterPro; IPR009013; Attachment_protein_shaft_sf.
DR   Pfam; PF00541; Adeno_knob; 1.
DR   Pfam; PF00608; Adeno_shaft; 2.
DR   PRINTS; PR00307; ADENOVSFIBRE.
DR   SUPFAM; SSF49835; SSF49835; 1.
DR   SUPFAM; SSF51225; SSF51225; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Capsid protein; Host nucleus; Host-virus interaction;
KW   Late protein; Viral attachment to host adhesion receptor;
KW   Viral attachment to host cell; Virion; Virus entry into host cell.
FT   CHAIN           1..325
FT                   /note="Fiber protein"
FT                   /id="PRO_0000221794"
FT   HELIX           130..132
FT                   /evidence="ECO:0007829|PDB:3EXV"
FT   STRAND          133..135
FT                   /evidence="ECO:0007829|PDB:3EXV"
FT   STRAND          151..153
FT                   /evidence="ECO:0007829|PDB:3EXV"
FT   STRAND          156..165
FT                   /evidence="ECO:0007829|PDB:3EXV"
FT   STRAND          168..177
FT                   /evidence="ECO:0007829|PDB:3EXV"
FT   HELIX           180..183
FT                   /evidence="ECO:0007829|PDB:3EXV"
FT   HELIX           184..187
FT                   /evidence="ECO:0007829|PDB:3EXV"
FT   STRAND          189..199
FT                   /evidence="ECO:0007829|PDB:3EXV"
FT   TURN            207..209
FT                   /evidence="ECO:0007829|PDB:3EXV"
FT   STRAND          210..212
FT                   /evidence="ECO:0007829|PDB:3EXV"
FT   HELIX           232..235
FT                   /evidence="ECO:0007829|PDB:3EXV"
FT   TURN            239..241
FT                   /evidence="ECO:0007829|PDB:3EXV"
FT   HELIX           247..253
FT                   /evidence="ECO:0007829|PDB:3EXV"
FT   STRAND          254..262
FT                   /evidence="ECO:0007829|PDB:3EXV"
FT   STRAND          268..279
FT                   /evidence="ECO:0007829|PDB:3EXV"
FT   STRAND          283..285
FT                   /evidence="ECO:0007829|PDB:2O39"
FT   STRAND          288..297
FT                   /evidence="ECO:0007829|PDB:3EXV"
FT   TURN            305..307
FT                   /evidence="ECO:0007829|PDB:3EXV"
FT   STRAND          316..322
FT                   /evidence="ECO:0007829|PDB:3EXV"
SQ   SEQUENCE   325 AA;  35538 MW;  3B3ACCA4CBDB3EFD CRC64;
     MTKRVRLSDS FNPVYPYEDE STSQHPFINP GFISPNGFTQ SPNGVLTLKC LTPLTTTGGS
     LQLKVGGGLT VDDTNGFLKE NISATTPLVK TGHSIGLPLG AGLGTNENKL CIKLGQGLTF
     NSNNICIDDN INTLWTGVNP TEANCQIMNS SESNDCKLIL TLVKTGALVT AFVYVIGVSN
     NFNMLTTHRN INFTAELFFD STGNLLTRLS SLKTPLNHKS GQNMATGAIT NAKGFMPSTT
     AYPFNDNSRE KENYIYGTCY YTASDRTAFP IDISVMLNRR AINDETSYCI RITWSWNTGD
     APEVQTSATT LVTSPFTFYY IREDD
//
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