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Database: UniProt
Entry: P36075
LinkDB: P36075
Original site: P36075 
ID   CUE2_YEAST              Reviewed;         443 AA.
AC   P36075; D6VXJ8;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   29-SEP-2021, entry version 157.
DE   RecName: Full=Ubiquitin-binding protein CUE2;
DE   AltName: Full=Coupling of ubiquitin conjugation to ER degradation protein 2;
GN   Name=CUE2; OrderedLocusNames=YKL090W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8196765; DOI=10.1038/369371a0;
RA   Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V.,
RA   Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P.,
RA   Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L.,
RA   Daignan-Fornier B., del Rey F., Dion C., Domdey H., Duesterhoeft A.,
RA   Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H.,
RA   Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L.,
RA   Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M.,
RA   Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H.,
RA   Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J.,
RA   Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H.,
RA   Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J.,
RA   Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S.,
RA   Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F.,
RA   Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R.,
RA   Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W.,
RA   Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M.,
RA   Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C.,
RA   Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H.,
RA   Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L.,
RA   van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S.,
RA   von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M.,
RA   Becker I., Mewes H.-W.;
RT   "Complete DNA sequence of yeast chromosome XI.";
RL   Nature 369:371-378(1994).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   STRUCTURE BY NMR OF 1-54 IN COMPLEX WITH UBIQUITIN.
RX   PubMed=12787503; DOI=10.1016/s0092-8674(03)00362-3;
RA   Kang R.S., Daniels C.M., Francis S.A., Shih S.C., Salerno W.J., Hicke L.,
RA   Radhakrishnan I.;
RT   "Solution structure of a CUE-ubiquitin complex reveals a conserved mode of
RT   ubiquitin binding.";
RL   Cell 113:621-630(2003).
CC   -!- SUBUNIT: Binds to ubiquitin. {ECO:0000269|PubMed:12787503}.
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DR   EMBL; Z28090; CAA81928.1; -; Genomic_DNA.
DR   EMBL; BK006944; DAA09068.1; -; Genomic_DNA.
DR   PIR; S37915; S37915.
DR   RefSeq; NP_012833.1; NM_001179656.1.
DR   PDB; 1OTR; NMR; -; A=6-54.
DR   PDBsum; 1OTR; -.
DR   SMR; P36075; -.
DR   BioGRID; 34043; 27.
DR   DIP; DIP-1917N; -.
DR   IntAct; P36075; 4.
DR   STRING; 4932.YKL090W; -.
DR   iPTMnet; P36075; -.
DR   MaxQB; P36075; -.
DR   PaxDb; P36075; -.
DR   PRIDE; P36075; -.
DR   EnsemblFungi; YKL090W_mRNA; YKL090W; YKL090W.
DR   GeneID; 853772; -.
DR   KEGG; sce:YKL090W; -.
DR   SGD; S000001573; CUE2.
DR   VEuPathDB; FungiDB:YKL090W; -.
DR   eggNOG; KOG2401; Eukaryota.
DR   HOGENOM; CLU_590497_0_0_1; -.
DR   InParanoid; P36075; -.
DR   OMA; NDDHESK; -.
DR   EvolutionaryTrace; P36075; -.
DR   PRO; PR:P36075; -.
DR   Proteomes; UP000002311; Chromosome XI.
DR   RNAct; P36075; protein.
DR   GO; GO:0004519; F:endonuclease activity; IDA:SGD.
DR   GO; GO:0043130; F:ubiquitin binding; IDA:SGD.
DR   GO; GO:0006379; P:mRNA cleavage; IDA:SGD.
DR   GO; GO:0070966; P:nuclear-transcribed mRNA catabolic process, no-go decay; IDA:SGD.
DR   CDD; cd14374; CUE1_Cue2p_like; 1.
DR   CDD; cd14375; CUE2_Cue2p_like; 1.
DR   InterPro; IPR003892; CUE.
DR   InterPro; IPR041809; Cue2_CUE1.
DR   InterPro; IPR041810; Cue2_CUE2.
DR   InterPro; IPR002625; Smr_dom.
DR   InterPro; IPR036063; Smr_dom_sf.
DR   InterPro; IPR009060; UBA-like_sf.
DR   Pfam; PF02845; CUE; 2.
DR   SMART; SM00546; CUE; 2.
DR   SMART; SM00463; SMR; 1.
DR   SUPFAM; SSF160443; SSF160443; 1.
DR   SUPFAM; SSF46934; SSF46934; 2.
DR   PROSITE; PS51140; CUE; 2.
DR   PROSITE; PS50828; SMR; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome; Repeat; Ubl conjugation pathway.
FT   CHAIN           1..443
FT                   /note="Ubiquitin-binding protein CUE2"
FT                   /id="PRO_0000079558"
FT   DOMAIN          8..51
FT                   /note="CUE 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00468"
FT   DOMAIN          55..98
FT                   /note="CUE 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00468"
FT   DOMAIN          347..443
FT                   /note="Smr"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00321"
FT   HELIX           9..19
FT                   /evidence="ECO:0007829|PDB:1OTR"
FT   STRAND          21..23
FT                   /evidence="ECO:0007829|PDB:1OTR"
FT   HELIX           25..34
FT                   /evidence="ECO:0007829|PDB:1OTR"
FT   TURN            35..37
FT                   /evidence="ECO:0007829|PDB:1OTR"
FT   HELIX           40..49
FT                   /evidence="ECO:0007829|PDB:1OTR"
SQ   SEQUENCE   443 AA;  50874 MW;  8B7BB872C2BDC734 CRC64;
     MSMDNNDDHE SKLSILMDMF PAISKSKLQV HLLENNNDLD LTIGLLLKEN DDKSTVDNEL
     HQLYDMFPQL DCSVIKDQFV INEKSVESTI SDLLNYETLQ KLKDNQANSP DSVKRNEKKN
     NWESTNDHIE SIIKFTDAPK NIAQEYLAEN GFDTVKAIIK IILDYYDKRD FKKDVDTFKV
     KRSPNTTVRG GRVQSSTGLA HVLKKGKESA NVAQESLKRP RSYKHSLDSP QMVELNELVA
     DNRDLKAINH EFLQKCLQFY DGDVVKVLNI SSLLIEDDKN ITKTWNFDEG FTLTSRDNCK
     QHLPKFSTPQ ISRRNEVGNT YKLPLHDKET PEGAVPVINN LFQTYRLDFH GFLPSEAVST
     LKLALNKWWS KEVAERELNS HNINSYGSKV QFVSPLIVVT GRGIHSIGGI SKVRLQVKSF
     LEKNHYIFWE ESSYFRIEGK KKK
//
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