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Database: UniProt
Entry: P42315
LinkDB: P42315
Original site: P42315 
ID   SCOA_BACSU              Reviewed;         238 AA.
AC   P42315;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   02-JUN-2021, entry version 127.
DE   RecName: Full=Probable succinyl-CoA:3-ketoacid coenzyme A transferase subunit A;
DE            EC=2.8.3.5;
DE   AltName: Full=Succinyl-CoA:3-oxoacid CoA-transferase;
DE            Short=OXCT A;
GN   Name=scoA; Synonyms=yxjD; OrderedLocusNames=BSU38990; ORFNames=N15K;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / BGSC1A1;
RX   PubMed=8969509; DOI=10.1099/13500872-142-11-3113;
RA   Yoshida K., Shindo K., Sano H., Seki S., Fujimura M., Yanai N., Miwa Y.,
RA   Fujita Y.;
RT   "Sequencing of a 65 kb region of the Bacillus subtilis genome containing
RT   the lic and cel loci, and creation of a 177 kb contig covering the gnt-
RT   sacXY region.";
RL   Microbiology 142:3113-3123(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate;
CC         Xref=Rhea:RHEA:24564, ChEBI:CHEBI:30031, ChEBI:CHEBI:35973,
CC         ChEBI:CHEBI:57292, ChEBI:CHEBI:90726; EC=2.8.3.5;
CC   -!- SUBUNIT: Heterodimer of a subunit A and a subunit B. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the 3-oxoacid CoA-transferase subunit A family.
CC       {ECO:0000305}.
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DR   EMBL; D83026; BAA11705.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB15925.1; -; Genomic_DNA.
DR   PIR; B70079; B70079.
DR   RefSeq; NP_391778.1; NC_000964.3.
DR   RefSeq; WP_003244373.1; NZ_JNCM01000034.1.
DR   PDB; 3CDK; X-ray; 2.59 A; A/C=1-238.
DR   PDBsum; 3CDK; -.
DR   SMR; P42315; -.
DR   STRING; 224308.BSU38990; -.
DR   PaxDb; P42315; -.
DR   EnsemblBacteria; CAB15925; CAB15925; BSU_38990.
DR   GeneID; 937468; -.
DR   KEGG; bsu:BSU38990; -.
DR   PATRIC; fig|224308.179.peg.4219; -.
DR   eggNOG; COG1788; Bacteria.
DR   InParanoid; P42315; -.
DR   OMA; LEYPIHG; -.
DR   PhylomeDB; P42315; -.
DR   BioCyc; BSUB:BSU38990-MONOMER; -.
DR   EvolutionaryTrace; P42315; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0008260; F:3-oxoacid CoA-transferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008775; F:acetate CoA-transferase activity; IBA:GO_Central.
DR   GO; GO:0008410; F:CoA-transferase activity; IBA:GO_Central.
DR   InterPro; IPR012792; 3-oxoacid_CoA-transf_A.
DR   InterPro; IPR004165; CoA_trans_fam_I.
DR   InterPro; IPR004163; CoA_transf_BS.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   PANTHER; PTHR13707; PTHR13707; 1.
DR   Pfam; PF01144; CoA_trans; 1.
DR   SMART; SM00882; CoA_trans; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   TIGRFAMs; TIGR02429; pcaI_scoA_fam; 1.
DR   PROSITE; PS01273; COA_TRANSF_1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome; Transferase.
FT   CHAIN           1..238
FT                   /note="Probable succinyl-CoA:3-ketoacid coenzyme A
FT                   transferase subunit A"
FT                   /id="PRO_0000157908"
FT   REGION          24..30
FT                   /note="CoA-binding"
FT                   /evidence="ECO:0000255"
FT   HELIX           8..12
FT                   /evidence="ECO:0007829|PDB:3CDK"
FT   STRAND          20..23
FT                   /evidence="ECO:0007829|PDB:3CDK"
FT   HELIX           33..42
FT                   /evidence="ECO:0007829|PDB:3CDK"
FT   STRAND          46..53
FT                   /evidence="ECO:0007829|PDB:3CDK"
FT   STRAND          57..59
FT                   /evidence="ECO:0007829|PDB:3CDK"
FT   HELIX           62..66
FT                   /evidence="ECO:0007829|PDB:3CDK"
FT   STRAND          70..77
FT                   /evidence="ECO:0007829|PDB:3CDK"
FT   HELIX           82..88
FT                   /evidence="ECO:0007829|PDB:3CDK"
FT   TURN            89..91
FT                   /evidence="ECO:0007829|PDB:3CDK"
FT   STRAND          92..97
FT                   /evidence="ECO:0007829|PDB:3CDK"
FT   HELIX           100..112
FT                   /evidence="ECO:0007829|PDB:3CDK"
FT   STRAND          116..120
FT                   /evidence="ECO:0007829|PDB:3CDK"
FT   TURN            121..124
FT                   /evidence="ECO:0007829|PDB:3CDK"
FT   HELIX           126..128
FT                   /evidence="ECO:0007829|PDB:3CDK"
FT   STRAND          133..136
FT                   /evidence="ECO:0007829|PDB:3CDK"
FT   STRAND          139..145
FT                   /evidence="ECO:0007829|PDB:3CDK"
FT   STRAND          149..160
FT                   /evidence="ECO:0007829|PDB:3CDK"
FT   HELIX           169..171
FT                   /evidence="ECO:0007829|PDB:3CDK"
FT   HELIX           175..181
FT                   /evidence="ECO:0007829|PDB:3CDK"
FT   STRAND          182..193
FT                   /evidence="ECO:0007829|PDB:3CDK"
FT   TURN            200..202
FT                   /evidence="ECO:0007829|PDB:3CDK"
FT   HELIX           207..209
FT                   /evidence="ECO:0007829|PDB:3CDK"
FT   STRAND          211..215
FT                   /evidence="ECO:0007829|PDB:3CDK"
SQ   SEQUENCE   238 AA;  25399 MW;  E88552A437098CE0 CRC64;
     MGKVLSSSKE AAKLIHDGDT LIAGGFGLCG IPEQLILSIR DQGVKDLTVV SNNCGVDDWG
     LGLLLANKQI KKMIASYVGE NKIFERQFLS GELEVELVPQ GTLAERIRAG GAGIPGFYTA
     TGVGTSIAEG KEHKTFGGRT YVLERGITGD VAIVKAWKAD TMGNLIFRKT ARNFNPIAAM
     AGKITIAEAE EIVEAGELDP DHIHTPGIYV QHVVLGASQE KRIEKRTVQQ ASGKGEAK
//
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