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Database: UniProt
Entry: P46898
LinkDB: P46898
Original site: P46898 
ID   RL6_BACSU               Reviewed;         179 AA.
AC   P46898;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   29-SEP-2021, entry version 131.
DE   RecName: Full=50S ribosomal protein L6 {ECO:0000255|HAMAP-Rule:MF_01365};
DE   AltName: Full=BL10;
GN   Name=rplF {ECO:0000255|HAMAP-Rule:MF_01365}; OrderedLocusNames=BSU01310;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC   3610 / NRRL NRS-744 / VKM B-501;
RX   PubMed=8635744; DOI=10.1016/0378-1119(95)00757-1;
RA   Suh J.-W., Boylan S.A., Oh S.H., Price C.W.;
RT   "Genetic and transcriptional organization of the Bacillus subtilis spc-
RT   alpha region.";
RL   Gene 169:17-23(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=8969501; DOI=10.1099/13500872-142-11-3039;
RA   Yasumoto K., Liu H., Jeong S.M., Ohashi Y., Kakinuma S., Tanaka K.,
RA   Kawamura F., Yoshikawa H., Takahashi H.;
RT   "Sequence analysis of a 50 kb region between spo0H and rrnH on the Bacillus
RT   subtilis chromosome.";
RL   Microbiology 142:3039-3046(1996).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [4] {ECO:0007744|PDB:6HA1, ECO:0007744|PDB:6HA8}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.10 ANGSTROMS) OF 1-179 WITH AND WITHOUT
RP   VIRGINIAMYCIN M.
RX   PubMed=30126986; DOI=10.1073/pnas.1808535115;
RA   Crowe-McAuliffe C., Graf M., Huter P., Takada H., Abdelshahid M.,
RA   Novacek J., Murina V., Atkinson G.C., Hauryliuk V., Wilson D.N.;
RT   "Structural basis for antibiotic resistance mediated by the Bacillus
RT   subtilis ABCF ATPase VmlR.";
RL   Proc. Natl. Acad. Sci. U.S.A. 115:8978-8983(2018).
CC   -!- FUNCTION: This protein binds to the 23S rRNA, and is important in its
CC       secondary structure. It is located near the subunit interface in the
CC       base of the L7/L12 stalk, and near the tRNA binding site of the
CC       peptidyltransferase center. {ECO:0000255|HAMAP-Rule:MF_01365}.
CC   -!- SUBUNIT: Part of the 50S ribosomal subunit.
CC       {ECO:0000269|PubMed:30126986}.
CC   -!- INTERACTION:
CC       P46898; P38424: engB; NbExp=2; IntAct=EBI-6401129, EBI-6401087;
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL6 family.
CC       {ECO:0000255|HAMAP-Rule:MF_01365}.
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DR   EMBL; L47971; AAB06814.1; -; Genomic_DNA.
DR   EMBL; D64125; BAA10981.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB11907.1; -; Genomic_DNA.
DR   PIR; B69695; B69695.
DR   RefSeq; NP_388012.1; NC_000964.3.
DR   RefSeq; WP_004399690.1; NZ_JNCM01000029.1.
DR   PDB; 3J3V; EM; 13.30 A; G=1-179.
DR   PDB; 3J3W; EM; 10.70 A; G=1-179.
DR   PDB; 3J9W; EM; 3.90 A; BH=1-179.
DR   PDB; 5NJT; EM; 3.80 A; a=2-176.
DR   PDB; 6HA1; EM; 3.10 A; G=1-179.
DR   PDB; 6HA8; EM; 3.50 A; G=1-179.
DR   PDB; 6HTQ; EM; 4.50 A; G=2-176.
DR   PDB; 6PPK; EM; 4.40 A; G=1-179.
DR   PDB; 6TNN; EM; 3.07 A; a=1-179.
DR   PDB; 6TPQ; EM; 3.07 A; a=1-179.
DR   PDB; 7AQC; EM; 2.99 A; G=1-179.
DR   PDB; 7AQD; EM; 3.10 A; G=1-179.
DR   PDB; 7AS8; EM; 2.90 A; I=1-179.
DR   PDB; 7AS9; EM; 3.50 A; I=1-179.
DR   PDBsum; 3J3V; -.
DR   PDBsum; 3J3W; -.
DR   PDBsum; 3J9W; -.
DR   PDBsum; 5NJT; -.
DR   PDBsum; 6HA1; -.
DR   PDBsum; 6HA8; -.
DR   PDBsum; 6HTQ; -.
DR   PDBsum; 6PPK; -.
DR   PDBsum; 6TNN; -.
DR   PDBsum; 6TPQ; -.
DR   PDBsum; 7AQC; -.
DR   PDBsum; 7AQD; -.
DR   PDBsum; 7AS8; -.
DR   PDBsum; 7AS9; -.
DR   SMR; P46898; -.
DR   IntAct; P46898; 1.
DR   STRING; 224308.BSU01310; -.
DR   jPOST; P46898; -.
DR   PaxDb; P46898; -.
DR   PRIDE; P46898; -.
DR   EnsemblBacteria; CAB11907; CAB11907; BSU_01310.
DR   GeneID; 938229; -.
DR   KEGG; bsu:BSU01310; -.
DR   PATRIC; fig|224308.179.peg.134; -.
DR   eggNOG; COG0097; Bacteria.
DR   InParanoid; P46898; -.
DR   OMA; KPDPYKG; -.
DR   PhylomeDB; P46898; -.
DR   BioCyc; BSUB:BSU01310-MONOMER; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR   Gene3D; 3.90.930.12; -; 2.
DR   HAMAP; MF_01365_B; Ribosomal_L6_B; 1.
DR   InterPro; IPR000702; Ribosomal_L6.
DR   InterPro; IPR020040; Ribosomal_L6_a/b-dom.
DR   InterPro; IPR036789; Ribosomal_L6_a/b-dom_sf.
DR   InterPro; IPR019906; Ribosomal_L6_bac-type.
DR   InterPro; IPR002358; Ribosomal_L6_CS.
DR   PANTHER; PTHR11655; PTHR11655; 1.
DR   PANTHER; PTHR11655:SF14; PTHR11655:SF14; 1.
DR   Pfam; PF00347; Ribosomal_L6; 2.
DR   PIRSF; PIRSF002162; Ribosomal_L6; 1.
DR   PRINTS; PR00059; RIBOSOMALL6.
DR   SUPFAM; SSF56053; SSF56053; 2.
DR   TIGRFAMs; TIGR03654; L6_bact; 1.
DR   PROSITE; PS00525; RIBOSOMAL_L6_1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW   RNA-binding; rRNA-binding.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..179
FT                   /note="50S ribosomal protein L6"
FT                   /id="PRO_0000131038"
FT   TURN            4..6
FT                   /evidence="ECO:0007829|PDB:7AQC"
FT   STRAND          16..19
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   STRAND          21..23
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   STRAND          25..28
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   STRAND          33..36
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   STRAND          42..47
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   STRAND          50..54
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   HELIX           60..81
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   STRAND          84..94
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   STRAND          96..98
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   STRAND          103..112
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   STRAND          114..116
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   STRAND          123..125
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   STRAND          127..130
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   STRAND          132..137
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   HELIX           139..150
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   TURN            151..153
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   STRAND          157..159
FT                   /evidence="ECO:0007829|PDB:7AS8"
FT   STRAND          162..164
FT                   /evidence="ECO:0007829|PDB:7AS8"
SQ   SEQUENCE   179 AA;  19509 MW;  C52DC1D1543E377E CRC64;
     MSRVGKKLLE IPSDVTVTLN DNNTVAVKGP KGELTRTFHP DMEIKVEDNV LTVARPSDQK
     EHRALHGTTR SLLGNMVEGV SKGFERGLEL VGVGYRASKS GNKLVLNVGY SHPVEIVPEE
     GIEIEVPSQT KVVVKGTDKE RVGAIAANIR AVRSPEPYKG KGIRYEGEVV RRKEGKSAK
//
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