ID PG108_VACCC Reviewed; 324 AA.
AC P20497;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 28-JAN-2026, entry version 91.
DE RecName: Full=Envelope protein H3;
DE AltName: Full=Ag35;
DE AltName: Full=Virion envelope protein p35;
GN Name=OPG108; ORFNames=H3L;
OS Vaccinia virus (strain Copenhagen) (VACV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX NCBI_TaxID=10249;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA Paoletti E.;
RT "The complete DNA sequence of vaccinia virus.";
RL Virology 179:247-266(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA Paoletti E.;
RT "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL Virology 179:517-563(1990).
CC -!- FUNCTION: Envelope protein that binds to heparan sulfate on the cell
CC surface and might provide virion attachment to target cell.
CC {ECO:0000250, ECO:0000250|UniProtKB:P07240}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000250|UniProtKB:P07240};
CC Single-pass membrane protein {ECO:0000250|UniProtKB:P07240}.
CC Note=Component of the mature virion (MV) membrane. Becomes membrane
CC associated presumably during virus maturation. The mature virion is
CC located in the cytoplasm of infected cells and is probably released by
CC cell lysis. {ECO:0000250|UniProtKB:P07240}.
CC -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC -!- PTM: Does not contain disulfide bonds. {ECO:0000250|UniProtKB:P07240}.
CC -!- MISCELLANEOUS: Immunodominant protein. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the orthopoxvirus OPG108 family. {ECO:0000305}.
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DR EMBL; M35027; AAA48090.1; -; Genomic_DNA.
DR PIR; C42514; C42514.
DR SMR; P20497; -.
DR ABCD; P20497; 7 sequenced antibodies.
DR Proteomes; UP000008269; Segment.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046718; P:symbiont entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR InterPro; IPR004900; Poxvirus_P35.
DR Pfam; PF03213; Pox_P35; 1.
PE 2: Evidence at transcript level;
KW Host-virus interaction; Late protein; Membrane; Signal-anchor;
KW Transmembrane; Transmembrane helix; Viral attachment to host cell;
KW Viral envelope protein; Virion; Virus entry into host cell.
FT CHAIN 1..324
FT /note="Envelope protein H3"
FT /id="PRO_0000099206"
FT TOPO_DOM 1..284
FT /note="Virion surface"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical; Signal-anchor"
FT /evidence="ECO:0000250"
FT TOPO_DOM 306..324
FT /note="Intravirion"
FT /evidence="ECO:0000255"
SQ SEQUENCE 324 AA; 37458 MW; ED326A2B3875EB32 CRC64;
MAAVKTPVIV VPVIDRPPSE TFPNVHEHIN DQKFDDVKDN EVMPEKRNVV VVKDDPDHYK
DYAFIQWTGG NIRNDDKYTH FFSGFCNTMC TEETKRNIAR HLALWDSNFF TELENKKVEY
VVIVENDNVI EDITFLRPVL KAMHDKKIDI LQMREIITGN KVKTELVMDK NHTIFTYTGG
YDVSLSAYII RVTTALNIVD EIIKSGGLSS GFYFEIARIE NEMKINRQIL DNAAKYVEHD
PRLVAEHRFE NMKPNFWSRI GTAAAKRYPG VMYAFTTPLI SFFGLFDINV IGLIVILFIM
FMLIFNVKSK LLWFLTGTFV TAFI
//
