ID Q0A787_ALKEH Unreviewed; 501 AA.
AC Q0A787;
DT 17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 17-OCT-2006, sequence version 1.
DT 18-JUN-2025, entry version 109.
DE RecName: Full=NADH-quinone oxidoreductase subunit M {ECO:0000256|ARBA:ARBA00019906};
DE AltName: Full=NADH dehydrogenase I subunit M {ECO:0000256|ARBA:ARBA00031584};
DE AltName: Full=NDH-1 subunit M {ECO:0000256|ARBA:ARBA00032798};
GN OrderedLocusNames=Mlg_1958 {ECO:0000313|EMBL:ABI57300.1};
OS Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1).
OC Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria;
OC Chromatiales; Ectothiorhodospiraceae; Alkalilimnicola.
OX NCBI_TaxID=187272 {ECO:0000313|EMBL:ABI57300.1, ECO:0000313|Proteomes:UP000001962};
RN [1] {ECO:0000313|Proteomes:UP000001962}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1101 / DSM 17681 / MLHE-1
RC {ECO:0000313|Proteomes:UP000001962};
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S.,
RA Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B.,
RA Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P.;
RT "Complete sequence of Alkalilimnicola ehrilichei MLHE-1.";
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004127}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004127}. Membrane
CC {ECO:0000256|RuleBase:RU000320}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU000320}.
CC -!- SIMILARITY: Belongs to the complex I subunit 4 family.
CC {ECO:0000256|ARBA:ARBA00009025}.
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DR EMBL; CP000453; ABI57300.1; -; Genomic_DNA.
DR RefSeq; WP_011629694.1; NC_008340.1.
DR AlphaFoldDB; Q0A787; -.
DR KEGG; aeh:Mlg_1958; -.
DR eggNOG; COG1008; Bacteria.
DR HOGENOM; CLU_007100_4_4_6; -.
DR OrthoDB; 9768329at2; -.
DR Proteomes; UP000001962; Chromosome.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0048039; F:ubiquinone binding; IEA:TreeGrafter.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR GO; GO:0015990; P:electron transport coupled proton transport; IEA:TreeGrafter.
DR InterPro; IPR000260; NADH4_N.
DR InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4.
DR InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR InterPro; IPR001750; ND/Mrp_TM.
DR NCBIfam; TIGR01972; NDH_I_M; 1.
DR NCBIfam; NF004499; PRK05846.1-3; 1.
DR NCBIfam; NF004501; PRK05846.1-5; 1.
DR PANTHER; PTHR43507; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4; 1.
DR PANTHER; PTHR43507:SF1; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4; 1.
DR Pfam; PF01059; Oxidored_q5_N; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01437; NUOXDRDTASE4.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:ABI57300.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001962};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|RuleBase:RU000320, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 36..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 84..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 199..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..263
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 301..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 344..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 67..122
FT /note="NADH:ubiquinone oxidoreductase chain 4 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01059"
FT DOMAIN 131..428
FT /note="NADH:quinone oxidoreductase/Mrp antiporter
FT transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00361"
SQ SEQUENCE 501 AA; 54788 MW; C97DC734FA40569D CRC64;
MFDGWLLSLL IWLPILGGVA VMVLGDSAPD RVRWTALGIA LVTFLASLPL YFGFEPGTHE
MQFVEQREWV SALQVYYHLG VDGISMPLII LTTFCTLLVV IAGWEVIKYR PSQYLAAFLI
MEGIMVGVFS ALDAILFYVF FEAMLVPMFL IIGIWGGANR IYATIKFFLY TFLGSVLMLV
AVIYLRLQAG SFGILDMHGL DLGLTAQVLI FLAFLGAFAV KVPMWPVHTW LPDAHVEAPT
GGSVILAAIM LKIGGYGFLR FSLPITPEAS MTLDWLIILM SLVAVAYIGL VAMVQKDMKK
LIAYSSIAHM GFVTLGFFLI FQIMANGGGE QGGMLALQGG MVQMISHGFI SAAMFLCVGV
LYDRMHSRQI ADYGGVINTM PWFGAFFVLF AMANAGLPGT SGFVGEFMVI LAAFQANFWY
AFVAGTTLVL GAAYSLWMVK RVIFGEVANE NVAKLEDVNR REVLVLGLLA AMVLLLGLWP
APLVEVMEPS LLHLLNQVTG A
//
