ID BETI_BURCM Reviewed; 194 AA.
AC Q0B713;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 18-JUN-2025, entry version 100.
DE RecName: Full=HTH-type transcriptional regulator BetI {ECO:0000255|HAMAP-Rule:MF_00768};
GN Name=betI {ECO:0000255|HAMAP-Rule:MF_00768}; OrderedLocusNames=Bamb_4510;
OS Burkholderia ambifaria (strain ATCC BAA-244 / DSM 16087 / CCUG 44356 / LMG
OS 19182 / AMMD) (Burkholderia cepacia (strain AMMD)).
OC Bacteria; Pseudomonadati; Pseudomonadota; Betaproteobacteria;
OC Burkholderiales; Burkholderiaceae; Burkholderia;
OC Burkholderia cepacia complex.
OX NCBI_TaxID=339670;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-244 / DSM 16087 / CCUG 44356 / LMG 19182 / AMMD;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Pitluck S., Bruce D., Chain P.,
RA Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Kim E., Parke J., Coenye T., Konstantinidis K.,
RA Ramette A., Tiedje J., Richardson P.;
RT "Complete sequence of chromosome 2 of Burkholderia cepacia AMMD.";
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Repressor involved in the biosynthesis of the osmoprotectant
CC glycine betaine. It represses transcription of the choline transporter
CC BetT and the genes of BetAB involved in the synthesis of glycine
CC betaine (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via
CC choline pathway [regulation].
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DR EMBL; CP000441; ABI90060.1; -; Genomic_DNA.
DR RefSeq; WP_011659481.1; NZ_CP009799.1.
DR AlphaFoldDB; Q0B713; -.
DR SMR; Q0B713; -.
DR GeneID; 93087470; -.
DR KEGG; bam:Bamb_4510; -.
DR PATRIC; fig|339670.21.peg.4844; -.
DR eggNOG; COG1309; Bacteria.
DR UniPathway; UPA00529; -.
DR Proteomes; UP000000662; Chromosome 2.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:TreeGrafter.
DR GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR HAMAP; MF_00768; HTH_type_BetI; 1.
DR InterPro; IPR039538; BetI_C.
DR InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR InterPro; IPR009057; Homeodomain-like_sf.
DR InterPro; IPR050109; HTH-type_TetR-like_transc_reg.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR InterPro; IPR017757; Tscrpt_rep_BetI.
DR NCBIfam; TIGR03384; betaine_BetI; 1.
DR NCBIfam; NF001978; PRK00767.1; 1.
DR PANTHER; PTHR30055:SF234; HTH-TYPE TRANSCRIPTIONAL REGULATOR BETI; 1.
DR PANTHER; PTHR30055; HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR; 1.
DR Pfam; PF13977; TetR_C_6; 1.
DR Pfam; PF00440; TetR_N; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR PROSITE; PS01081; HTH_TETR_1; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..194
FT /note="HTH-type transcriptional regulator BetI"
FT /id="PRO_1000083554"
FT DOMAIN 8..68
FT /note="HTH tetR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00768"
FT DNA_BIND 31..50
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00768"
SQ SEQUENCE 194 AA; 21316 MW; A8AEEFFD77B72A81 CRC64;
MPKVGMREIR RAQLIDATLR SIDEAGLPGT TLASVAQRAN ISTGIVSHYF GDKDGLLEAT
MRHVLRDLWA ATTQRRVAAR KDPRSRLRAI VAANFDDTQV SAPVMKTWLA FWSQSMHDAM
LKRLQHVNTR RLHSNLCAEF AKALPRAKAR QAASGLAALI DGLWLRGALA GGPIDTRAAL
KLAHDYIDLL LASD
//
