ID Q19BJ7_XENLA Unreviewed; 676 AA.
AC Q19BJ7;
DT 11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2006, sequence version 1.
DT 28-JAN-2026, entry version 65.
DE RecName: Full=Zinc finger protein 750 {ECO:0000256|ARBA:ARBA00040216};
GN Name=znf750.S {ECO:0000313|RefSeq:NP_001089178.1,
GN ECO:0000313|Xenbase:XB-GENE-6251680};
GN Synonyms=BENI {ECO:0000313|RefSeq:NP_001089178.1}, SG1
GN {ECO:0000313|EMBL:ABF74593.1}, sg1 {ECO:0000313|EMBL:AAI69498.1,
GN ECO:0000313|RefSeq:NP_001089178.1}, znf750
GN {ECO:0000313|RefSeq:NP_001089178.1}, znf750-a
GN {ECO:0000313|RefSeq:NP_001089178.1}, znf750-b
GN {ECO:0000313|RefSeq:NP_001089178.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:ABF74593.1};
RN [1] {ECO:0000313|RefSeq:NP_001089178.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:ABF74593.1, ECO:0000313|RefSeq:NP_001089178.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16916602; DOI=10.1016/j.mod.2006.04.006;
RA Chalmers A.D., Lachani K., Shin Y., Sherwood V., Cho K.W., Papalopulu N.;
RT "Grainyhead-like 3, a transcription factor identified in a microarray
RT screen, promotes the specification of the superficial layer of the
RT embryonic epidermis.";
RL Mech. Dev. 123:702-718(2006).
RN [3] {ECO:0000313|EMBL:AAI69498.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula {ECO:0000313|EMBL:AAI69498.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_001089178.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (APR-2025) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; BC169498; AAI69498.1; -; mRNA.
DR EMBL; BC169500; AAI69500.1; -; mRNA.
DR EMBL; DQ530237; ABF74593.1; -; mRNA.
DR RefSeq; NP_001089178.1; NM_001095709.1.
DR AlphaFoldDB; Q19BJ7; -.
DR GeneID; 734220; -.
DR KEGG; xla:734220; -.
DR AGR; Xenbase:XB-GENE-6251680; -.
DR CTD; 734220; -.
DR Xenbase; XB-GENE-6251680; znf750.S.
DR OrthoDB; 8933073at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10S.
DR Bgee; 734220; Expressed in zone of skin and 9 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0008544; P:epidermis development; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR039363; ZNF750.
DR InterPro; IPR039064; ZNF750_Znf.
DR PANTHER; PTHR14678; PROLINE-RICH PROTEIN 35-RELATED; 1.
DR PANTHER; PTHR14678:SF1; ZINC FINGER PROTEIN 750; 1.
DR Pfam; PF15269; zf-C2H2_7; 1.
PE 2: Evidence at transcript level;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 6..57
FT /note="Zinc finger protein 750-like zinc finger"
FT /evidence="ECO:0000259|Pfam:PF15269"
FT REGION 373..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 598..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 676 AA; 74937 MW; 03010AA5DF43A0C9 CRC64;
MSLVKERKPK KPHYIPRPPG KPFKFKCFQC PFTCNEKSHL FNHMKYGLCK NSITVVTDQD
RITKNPKVNS IDQKQTSNEP FAKSSVPALN GFTNLESKTQ HNVAREEVKD NLDLKNDAKH
HLERTTVSKE VTLSLPVAIS QINKPPSLDG AMRPSAFIPV GEHRLIKGTE NPSIPELTSI
SAEPAKGVHS IKSAFHSLPT PWKSGLVSPD FSQKSSMPRY IHPMISEYPP QFYSEAGLPA
VFSPYLFPQT ECENPMLSVY SSPDQRPFLP HPLQSSGLPL PKPISAHFEH YRLLQQFQQN
PQLHYGFYRP TEHPYLSYGL KVPSVPGLSK EHISHSMDSP ACIYPSSHPS RLYPLEGFQK
FFEIQKEISP VPAKNLDSKS DSDSVKMSPR AGSAATGSPG RPSPTNFTQN SQGHEGIFDL
SNKSTSTSDI IGKDVTSGKA VRKSTDSQTI ISRENSPSFR NNEVQSHSDS IIFTDDAVPH
DNTIVPLNLS KKSEVEARDV DTVHNSNSNK ECVGFMEMQD FPLNLSVKDS GSNHNTLCAD
ERLSLPRQST SPPIYQVIHT TDKRSPTSRG IHSLGIIENC DEQKQSAAVA LCQLATSSPG
VPLRGTEDEF PEKETVVPEQ VHPRSPAAQE TETDIGARGQ KRTNSKDPGK SQSSNKKHKA
VDSGRMFTLR KRPRVS
//
