ID Q231U3_TETTS Unreviewed; 418 AA.
AC Q231U3;
DT 18-APR-2006, integrated into UniProtKB/TrEMBL.
DT 16-APR-2014, sequence version 2.
DT 02-APR-2025, entry version 81.
DE SubName: Full=IBR domain protein {ECO:0000313|EMBL:EAR91357.2};
GN ORFNames=TTHERM_00736520 {ECO:0000313|EMBL:EAR91357.2};
OS Tetrahymena thermophila (strain SB210).
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC Tetrahymena.
OX NCBI_TaxID=312017 {ECO:0000313|EMBL:EAR91357.2, ECO:0000313|Proteomes:UP000009168};
RN [1] {ECO:0000313|Proteomes:UP000009168}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB210 {ECO:0000313|Proteomes:UP000009168};
RX PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA Hamilton E.P., Orias E.;
RT "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT model eukaryote.";
RL PLoS Biol. 4:1620-1642(2006).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; GG662786; EAR91357.2; -; Genomic_DNA.
DR RefSeq; XP_001011602.2; XM_001011602.2.
DR AlphaFoldDB; Q231U3; -.
DR STRING; 312017.Q231U3; -.
DR EnsemblProtists; EAR91357; EAR91357; TTHERM_00736520.
DR GeneID; 7823311; -.
DR KEGG; tet:TTHERM_00736520; -.
DR eggNOG; KOG1815; Eukaryota.
DR HOGENOM; CLU_588636_0_0_1; -.
DR InParanoid; Q231U3; -.
DR OrthoDB; 5986204at2759; -.
DR Proteomes; UP000009168; Unassembled WGS sequence.
DR GO; GO:0000151; C:ubiquitin ligase complex; IEA:TreeGrafter.
DR GO; GO:0043130; F:ubiquitin binding; IEA:TreeGrafter.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:TreeGrafter.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:TreeGrafter.
DR GO; GO:0097039; P:protein linear polyubiquitination; IEA:TreeGrafter.
DR CDD; cd20335; BRcat_RBR; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR051628; LUBAC_E3_Ligases.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22770:SF13; RING-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22770; UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED; 1.
DR Pfam; PF01485; IBR; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000009168};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 249..418
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 253..303
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 418 AA; 50021 MW; A68447FD99A0C337 CRC64;
MINIIYPNSQ LKLVALYLFF KINSKSLKQI LLFQLLLHLK VSTNQIKSGS RFDIRSNLFL
VFSFLVSQKR KKSELHDFLL NSTKKLLIKL QFQKIKKIIS KIRKERNLFN QDRNIKYFKM
SSFQSIQKLK VSEIQELLAP LSSINVDKDL LVFIIGTQYA YKKINKDQLN EFVTQIIQLY
QQCKSKGQYL IIEQVFSQLI DGEEQEPLSF IKYQYDSNFK QMNLNSQSKP LREQQDDKIE
ESKEEQKSEI WNCDICFEKM TDQDYWPIEC CHNTYHRVCL KKYFNSQVEE RRFPIKCVNN
KCPQVVSQQD IREILNDSDF QKYSYFQIKN YIEKQGDQAS WCLTPDCQYA FILENNQKRL
DCPFCKKSYL PNLQLDLSQK FDLQRKQNSE QLFRRRCKIL KISQRLKIQV MQLMQNVG
//
