ID Q2IN09_ANADE Unreviewed; 649 AA.
AC Q2IN09;
DT 07-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 07-MAR-2006, sequence version 1.
DT 28-JAN-2026, entry version 115.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN OrderedLocusNames=Adeh_0419 {ECO:0000313|EMBL:ABC80195.1};
OS Anaeromyxobacter dehalogenans (strain 2CP-C).
OC Bacteria; Pseudomonadati; Myxococcota; Myxococcia; Myxococcales;
OC Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter.
OX NCBI_TaxID=290397 {ECO:0000313|EMBL:ABC80195.1, ECO:0000313|Proteomes:UP000001935};
RN [1] {ECO:0000313|EMBL:ABC80195.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=2CP-C {ECO:0000313|EMBL:ABC80195.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R.,
RA Gilna P., Kiss H., Schmutz J., Larimer F., Land M., Kyrpides N.,
RA Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R.,
RA Zhulin I.B., Loeffler F.E., Richardson P.;
RT "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CP000251; ABC80195.1; -; Genomic_DNA.
DR RefSeq; WP_011419478.1; NC_007760.1.
DR AlphaFoldDB; Q2IN09; -.
DR STRING; 290397.Adeh_0419; -.
DR KEGG; ade:Adeh_0419; -.
DR eggNOG; COG3276; Bacteria.
DR HOGENOM; CLU_023030_3_0_7; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000001935; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR CDD; cd15491; selB_III; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 3.
DR InterPro; IPR057335; Beta-barrel_SelB.
DR InterPro; IPR050055; EF-Tu_GTPase.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR015190; Elong_fac_SelB-wing-hlx_typ-2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR005225; Small_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF25461; Beta-barrel_SelB; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09106; WHD_2nd_SelB; 1.
DR Pfam; PF09107; WHD_3rd_SelB; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 3.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Elongation factor {ECO:0000313|EMBL:ABC80195.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}.
FT DOMAIN 1..176
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 649 AA; 67705 MW; B5E5F9B2B06B668E CRC64;
MKRVVIGTAG HIDHGKTSLV RALTGIDTDR LRDEKRRGIT IELGFAHLAL PDGSVAGVVD
VPGHERFVRS MAAGAGGIDL VVLVIAADEG VMPQTREHLD ICRLLGVPRG LVAVTKADLL
PELGADWLPL LEQDVREVTR GTFLEGAPIV PVSSATGEGL DALRAALGAL AAEVPERPAD
GPLFLPVDRA FSMKGFGTVV TGTLLSGQIA EGDAAALLPA SAGGEGLRVR SVQVHGKPTP
RALAGQRTAV NLPGIEPAAI RRGQVLVHPG VVPASSIIDA ELTLLAAAPK PLRHRAKLLL
HVGTTQVPAV ISLLDRAELA PGATAHAQLR LAEPAAALPG QRFILRGFAV LEGRGKTVGG
GRVLAVAAPK RRRGRPESLA QLAALAGPDP EARLATVLAM AGPAGLDLPA LVGRTALSPK
AAQGTLDRLG ARGGAVLFDR ERRAYVAGPV AQELTRRMAA AVAAFHRDHP LAAGMGREAL
RGKLPPVTDP RLFQRLLAQA AERGELVVEG DVVREKGHAA ASGESAGGAL KEKVAAALAK
GGLTPPWLAE LPGAVGASAP DVQAVLKLLA AEGRALRVSS ELYFDAAAVK ALEAKLVAWL
RERRQITTQE FKDLVGATRK HVIPLAEYFD REKVTLRVGE KRVLRGEGR
//
