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Database: UniProt
Entry: Q2NKV2
LinkDB: Q2NKV2
Original site: Q2NKV2 
ID   APC13_BOVIN             Reviewed;          74 AA.
AC   Q2NKV2;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   23-FEB-2022, entry version 90.
DE   RecName: Full=Anaphase-promoting complex subunit 13;
DE            Short=APC13;
DE   AltName: Full=Cyclosome subunit 13;
GN   Name=ANAPC13;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC       (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC       progression through mitosis and the G1 phase of the cell cycle. The
CC       APC/C complex acts by mediating ubiquitination and subsequent
CC       degradation of target proteins: it mainly mediates the formation of
CC       'Lys-11'-linked polyubiquitin chains and, to a lower extent, the
CC       formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By
CC       similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: The mammalian APC/C is composed at least of 14 distinct
CC       subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6,
CC       ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and
CC       ANAPC16 that assemble into a complex of at least 19 chains with a
CC       combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1
CC       and FBXO5. {ECO:0000250|UniProtKB:Q9BS18}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the APC13 family. {ECO:0000305}.
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DR   EMBL; BC111620; AAI11621.1; -; mRNA.
DR   RefSeq; NP_001106700.1; NM_001113229.2.
DR   RefSeq; NP_001106705.1; NM_001113234.2.
DR   RefSeq; XP_005201988.1; XM_005201931.3.
DR   RefSeq; XP_005201989.1; XM_005201932.3.
DR   RefSeq; XP_005201991.1; XM_005201934.3.
DR   PDB; 5A31; EM; 4.30 A; M=1-74.
DR   PDB; 5G05; EM; 3.40 A; M=1-74.
DR   PDBsum; 5A31; -.
DR   PDBsum; 5G05; -.
DR   SMR; Q2NKV2; -.
DR   DIP; DIP-61975N; -.
DR   STRING; 9913.ENSBTAP00000019228; -.
DR   PaxDb; Q2NKV2; -.
DR   Ensembl; ENSBTAT00000019228; ENSBTAP00000019228; ENSBTAG00000014461.
DR   GeneID; 614347; -.
DR   KEGG; bta:614347; -.
DR   CTD; 25847; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014461; -.
DR   VGNC; VGNC:25881; ANAPC13.
DR   eggNOG; ENOG502S4J1; Eukaryota.
DR   GeneTree; ENSGT00390000008673; -.
DR   HOGENOM; CLU_199969_0_0_1; -.
DR   InParanoid; Q2NKV2; -.
DR   OMA; DEGWRKE; -.
DR   OrthoDB; 1635284at2759; -.
DR   TreeFam; TF105448; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000009136; Chromosome 1.
DR   Bgee; ENSBTAG00000014461; Expressed in pons and 98 other tissues.
DR   GO; GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.
DR   InterPro; IPR008401; Apc13.
DR   PANTHER; PTHR28672; PTHR28672; 1.
DR   Pfam; PF05839; Apc13p; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell cycle; Cell division; Mitosis; Nucleus;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..74
FT                   /note="Anaphase-promoting complex subunit 13"
FT                   /id="PRO_0000253979"
FT   REGION          33..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   HELIX           9..15
FT                   /evidence="ECO:0007829|PDB:5G05"
FT   HELIX           18..21
FT                   /evidence="ECO:0007829|PDB:5G05"
FT   STRAND          34..36
FT                   /evidence="ECO:0007829|PDB:5G05"
FT   HELIX           50..55
FT                   /evidence="ECO:0007829|PDB:5G05"
SQ   SEQUENCE   74 AA;  8521 MW;  F3C52A7E3821CB3B CRC64;
     MDSEVQRDGR ILDLIDDAWR EDKLPYEDVA IPLNELPEPE QDNGGTTESV KEQEMKWTDL
     ALQYLHENVP PIGN
//
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