ID COF3_DICDI Reviewed; 138 AA.
AC Q556H5; Q86K24;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 10-JUN-2026, entry version 96.
DE RecName: Full=Cofilin-3;
GN Name=cofD-1; ORFNames=DDB_G0272646;
GN and
GN Name=cofD-2; ORFNames=DDB_G0274057;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Controls actin polymerization and depolymerization.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the actin-binding proteins ADF family.
CC {ECO:0000305}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
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DR EMBL; AAFI02000011; EAL70462.1; -; Genomic_DNA.
DR EMBL; AAFI02000009; EAL70960.1; -; Genomic_DNA.
DR RefSeq; XP_644387.1; XM_639295.1.
DR RefSeq; XP_645026.1; XM_639934.1.
DR AlphaFoldDB; Q556H5; -.
DR SMR; Q556H5; -.
DR FunCoup; Q556H5; 3.
DR STRING; 44689.Q556H5; -.
DR PaxDb; 44689-Q556H5; -.
DR GeneID; 8618703; -.
DR GeneID; 8619273; -.
DR KEGG; ddi:DDB_G0272646; -.
DR KEGG; ddi:DDB_G0274057; -.
DR dictyBase; DDB_G0272646; cofD-1.
DR dictyBase; DDB_G0274057; cofD-2.
DR VEuPathDB; AmoebaDB:DDB_G0274057; -.
DR eggNOG; KOG1735; Eukaryota.
DR HOGENOM; CLU_1809787_0_0_1; -.
DR InParanoid; Q556H5; -.
DR PhylomeDB; Q556H5; -.
DR PRO; PR:Q556H5; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0015629; C:actin cytoskeleton; ISS:dictyBase.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0030042; P:actin filament depolymerization; IBA:GO_Central.
DR GO; GO:0051014; P:actin filament severing; IBA:GO_Central.
DR CDD; cd11286; ADF_cofilin_like; 1.
DR FunFam; 3.40.20.10:FF:000125; Cofilin-2; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR InterPro; IPR002108; ADF-H.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR017904; ADF/Cofilin.
DR PANTHER; PTHR11913; COFILIN-RELATED; 1.
DR Pfam; PF00241; Cofilin_ADF; 1.
DR SMART; SM00102; ADF; 1.
DR SUPFAM; SSF55753; Actin depolymerizing proteins; 1.
DR PROSITE; PS51263; ADF_H; 1.
PE 3: Inferred from homology;
KW Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..138
FT /note="Cofilin-3"
FT /id="PRO_0000365597"
FT DOMAIN 7..134
FT /note="ADF-H"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00599"
SQ SEQUENCE 138 AA; 15582 MW; 69006853764FBE52 CRC64;
MTTPKPTIAK ISPECQTHFQ DIKFRNKYQG ILLKVNEESN MVVDKTLVAE GEFSELAQSL
PTDQCRIIIY RYKSGEGSKL FFIYWGPDSA PQQDKLIYGN AKVTLAITLK GIDHKISASN
LKEISEQVFI DRITPKTA
//
