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Database: UniProt
Entry: Q59HN8
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Original site: Q59HN8 
ID   RAPH_BACSU              Reviewed;         376 AA.
AC   Q59HN8; O31508; P40771;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 2.
DT   02-JUN-2021, entry version 69.
DE   RecName: Full=Response regulator aspartate phosphatase H;
DE            EC=3.1.-.-;
DE   AltName: Full=PSP28;
GN   Name=rapH; Synonyms=yeeH, yzqA; OrderedLocusNames=BSU06830;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [2]
RP   SEQUENCE REVISION TO C-TERMINUS.
RX   PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA   Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA   Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT   "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT   168 reference genome a decade later.";
RL   Microbiology 155:1758-1775(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 318-376, AND INDUCTION.
RC   STRAIN=168;
RX   PubMed=16553878; DOI=10.1111/j.1365-2958.2006.05059.x;
RA   Hayashi K., Kensuke T., Kobayashi K., Ogasawara N., Ogura M.;
RT   "Bacillus subtilis RghR (YvaN) represses rapG and rapH, which encode
RT   inhibitors of expression of the srfA operon.";
RL   Mol. Microbiol. 59:1714-1729(2006).
CC   -!- INTERACTION:
CC       Q59HN8; P06628: spo0F; NbExp=2; IntAct=EBI-15913371, EBI-6418009;
CC   -!- INDUCTION: Repressed by RghR. {ECO:0000269|PubMed:16553878}.
CC   -!- SIMILARITY: Belongs to the RAP family. {ECO:0000305}.
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DR   EMBL; AL009126; CAB12503.2; -; Genomic_DNA.
DR   EMBL; AB207815; BAD91217.1; -; Genomic_DNA.
DR   PIR; C69689; C69689.
DR   RefSeq; NP_388565.2; NC_000964.3.
DR   RefSeq; WP_003243267.1; NZ_JNCM01000032.1.
DR   PDB; 3Q15; X-ray; 2.19 A; A/B=1-376.
DR   PDBsum; 3Q15; -.
DR   SMR; Q59HN8; -.
DR   DIP; DIP-58964N; -.
DR   IntAct; Q59HN8; 1.
DR   STRING; 224308.BSU06830; -.
DR   PaxDb; Q59HN8; -.
DR   PRIDE; Q59HN8; -.
DR   EnsemblBacteria; CAB12503; CAB12503; BSU_06830.
DR   GeneID; 936065; -.
DR   KEGG; bsu:BSU06830; -.
DR   PATRIC; fig|224308.179.peg.742; -.
DR   eggNOG; COG0457; Bacteria.
DR   InParanoid; Q59HN8; -.
DR   OMA; CIQEYTE; -.
DR   PhylomeDB; Q59HN8; -.
DR   BioCyc; BSUB:BSU06830-MONOMER; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR040702; Rap_N.
DR   InterPro; IPR013026; TPR-contain_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   Pfam; PF18801; RapH_N; 1.
DR   Pfam; PF13176; TPR_7; 1.
DR   SMART; SM00028; TPR; 6.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50005; TPR; 4.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Hydrolase; Protein phosphatase; Reference proteome; Repeat;
KW   TPR repeat.
FT   CHAIN           1..376
FT                   /note="Response regulator aspartate phosphatase H"
FT                   /id="PRO_0000106442"
FT   REPEAT          99..132
FT                   /note="TPR 1"
FT   REPEAT          139..172
FT                   /note="TPR 2"
FT   REPEAT          180..213
FT                   /note="TPR 3"
FT   REPEAT          220..253
FT                   /note="TPR 4"
FT   REPEAT          259..292
FT                   /note="TPR 5"
FT   REPEAT          334..367
FT                   /note="TPR 6"
FT   HELIX           7..22
FT                   /evidence="ECO:0007829|PDB:3Q15"
FT   HELIX           26..39
FT                   /evidence="ECO:0007829|PDB:3Q15"
FT   HELIX           40..42
FT                   /evidence="ECO:0007829|PDB:3Q15"
FT   HELIX           47..65
FT                   /evidence="ECO:0007829|PDB:3Q15"
FT   HELIX           79..87
FT                   /evidence="ECO:0007829|PDB:3Q15"
FT   HELIX           88..90
FT                   /evidence="ECO:0007829|PDB:3Q15"
FT   HELIX           91..111
FT                   /evidence="ECO:0007829|PDB:3Q15"
FT   HELIX           115..126
FT                   /evidence="ECO:0007829|PDB:3Q15"
FT   HELIX           127..131
FT                   /evidence="ECO:0007829|PDB:3Q15"
FT   HELIX           135..151
FT                   /evidence="ECO:0007829|PDB:3Q15"
FT   HELIX           155..170
FT                   /evidence="ECO:0007829|PDB:3Q15"
FT   HELIX           176..192
FT                   /evidence="ECO:0007829|PDB:3Q15"
FT   HELIX           196..212
FT                   /evidence="ECO:0007829|PDB:3Q15"
FT   HELIX           216..233
FT                   /evidence="ECO:0007829|PDB:3Q15"
FT   HELIX           236..253
FT                   /evidence="ECO:0007829|PDB:3Q15"
FT   HELIX           255..257
FT                   /evidence="ECO:0007829|PDB:3Q15"
FT   HELIX           258..271
FT                   /evidence="ECO:0007829|PDB:3Q15"
FT   HELIX           275..288
FT                   /evidence="ECO:0007829|PDB:3Q15"
FT   HELIX           297..308
FT                   /evidence="ECO:0007829|PDB:3Q15"
FT   STRAND          309..311
FT                   /evidence="ECO:0007829|PDB:3Q15"
FT   HELIX           314..326
FT                   /evidence="ECO:0007829|PDB:3Q15"
FT   HELIX           330..346
FT                   /evidence="ECO:0007829|PDB:3Q15"
FT   HELIX           350..370
FT                   /evidence="ECO:0007829|PDB:3Q15"
SQ   SEQUENCE   376 AA;  44003 MW;  74FABAA843676A74 CRC64;
     MSQAIPSSRV GVKINEWYKM IRQFSVPDAE ILKAEVEQDI QQMEEDQDLL IYYSLMCFRH
     QLMLDYLEPG KTYGNRPTVT ELLETIETPQ KKLTGLLKYY SLFFRGMYEF DQKEYVEAIG
     YYREAEKELP FVSDDIEKAE FHFKVAEAYY HMKQTHVSMY HILQALDIYQ NHPLYSIRTI
     QSLFVIAGNY DDFKHYDKAL PHLEAALELA MDIQNDRFIA ISLLNIANSY DRSGDDQMAV
     EHFQKAAKVS REKVPDLLPK VLFGLSWTLC KAGQTQKAFQ FIEEGLDHIT ARSHKFYKEL
     FLFLQAVYKE TVDERKIHDL LSYFEKKNLH AYIEACARSA AAVFESSCHF EQAAAFYRKV
     LKAQEDILKG ECLYAY
//
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