GenomeNet

Database: UniProt
Entry: Q6CRA3
LinkDB: Q6CRA3
Original site: Q6CRA3 
ID   Q6CRA3_KLULA            Unreviewed;       227 AA.
AC   Q6CRA3;
DT   16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT   16-AUG-2004, sequence version 1.
DT   07-APR-2021, entry version 103.
DE   SubName: Full=KLLA0D10659p {ECO:0000313|EMBL:CAH00632.1};
GN   ORFNames=KLLA0_D10659g {ECO:0000313|EMBL:CAH00632.1};
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590 {ECO:0000313|Proteomes:UP000000598};
RN   [1] {ECO:0000313|EMBL:CAH00632.1, ECO:0000313|Proteomes:UP000000598}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
RC   WM37 {ECO:0000313|Proteomes:UP000000598};
RX   PubMed=15229592; DOI=10.1038/nature02579;
RG   Genolevures;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.F., Straub M.L.,
RA   Suleau A., Swennene D., Tekaia F., Wesolowski-Louvel M., Westhof E.,
RA   Wirth B., Zeniou-Meyer M., Zivanovic I., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
RN   [2] {ECO:0007829|PDB:3J80, ECO:0007829|PDB:3J81}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.75 ANGSTROMS).
RX   PubMed=25417110; DOI=10.1016/j.cell.2014.10.001;
RA   Hussain T., Llacer J.L., Fernandez I.S., Munoz A., Martin-Marcos P.,
RA   Savva C.G., Lorsch J.R., Hinnebusch A.G., Ramakrishnan V.;
RT   "Structural changes enable start codon recognition by the eukaryotic
RT   translation initiation complex.";
RL   Cell 159:597-607(2014).
RN   [3] {ECO:0007829|PDB:3JAM, ECO:0007829|PDB:3JAP}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.46 ANGSTROMS).
RX   PubMed=26212456; DOI=10.1016/j.molcel.2015.06.033;
RA   Llacer J.L., Hussain T., Marler L., Aitken C.E., Thakur A., Lorsch J.R.,
RA   Hinnebusch A.G., Ramakrishnan V.;
RT   "Conformational differences between open and closed states of the
RT   eukaryotic translation initiation complex.";
RL   Mol. Cell 59:399-412(2015).
RN   [4] {ECO:0007829|PDB:5IT7, ECO:0007829|PDB:5IT9}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.60 ANGSTROMS) OF 22-227.
RX   PubMed=27159451; DOI=10.7554/eLife.13567;
RA   Murray J., Savva C.G., Shin B.S., Dever T.E., Ramakrishnan V.,
RA   Fernandez I.S.;
RT   "Structural characterization of ribosome recruitment and translocation by
RT   type IV IRES.";
RL   Elife 5:0-0(2016).
RN   [5] {ECO:0007829|PDB:6FYX, ECO:0007829|PDB:6FYY}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.05 ANGSTROMS).
RX   PubMed=30475211; DOI=10.7554/eLife.39273;
RA   Llacer J.L., Hussain T., Saini A.K., Nanda J.S., Kaur S., Gordiyenko Y.,
RA   Kumar R., Hinnebusch A.G., Lorsch J.R., Ramakrishnan V.;
RT   "Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal
RT   subunit to promote start-codon recognition.";
RL   Elife 7:0-0(2018).
RN   [6] {ECO:0007829|PDB:6GSM, ECO:0007829|PDB:6GSN}
RP   STRUCTURE BY ELECTRON MICROSCOPY (5.75 ANGSTROMS) OF 22-227.
RA   Llacer J.L., Hussain T., Gordiyenko Y., Ramakrishnan V.;
RT   "Towards a model of eIF3 on the 40S subunit interface in eukaryotic
RT   translation initiation.";
RL   Submitted (JUN-2018) to the PDB data bank.
RN   [7] {ECO:0007829|PDB:6UZ7}
RP   STRUCTURE BY ELECTRON MICROSCOPY (3.60 ANGSTROMS).
RX   PubMed=31900355; DOI=10.1073/pnas.1916436117;
RA   Huang B.Y., Fernandez I.S.;
RT   "Long-range interdomain communications in eIF5B regulate GTP hydrolysis and
RT   translation initiation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 117:1429-1437(2020).
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uS7 family.
CC       {ECO:0000256|ARBA:ARBA00007151, ECO:0000256|RuleBase:RU003619}.
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DR   EMBL; CR382124; CAH00632.1; -; Genomic_DNA.
DR   RefSeq; XP_453536.1; XM_453536.1.
DR   PDB; 3J80; EM; 3.75 A; F=1-227.
DR   PDB; 3J81; EM; 4.00 A; F=1-227.
DR   PDB; 3JAM; EM; 3.46 A; F=1-227.
DR   PDB; 3JAP; EM; 4.90 A; F=1-227.
DR   PDB; 3JAQ; EM; 6.00 A; F=1-227.
DR   PDB; 5IT7; EM; 3.60 A; F=22-227.
DR   PDB; 5IT9; EM; 3.80 A; F=22-227.
DR   PDB; 6FYX; EM; 3.05 A; F=1-227.
DR   PDB; 6FYY; EM; 3.05 A; F=1-227.
DR   PDB; 6GSM; EM; 5.15 A; F=22-227.
DR   PDB; 6GSN; EM; 5.75 A; F=22-227.
DR   PDB; 6UZ7; EM; 3.60 A; F=1-227.
DR   PDBsum; 3J80; -.
DR   PDBsum; 3J81; -.
DR   PDBsum; 3JAM; -.
DR   PDBsum; 3JAP; -.
DR   PDBsum; 3JAQ; -.
DR   PDBsum; 5IT7; -.
DR   PDBsum; 5IT9; -.
DR   PDBsum; 6FYX; -.
DR   PDBsum; 6FYY; -.
DR   PDBsum; 6GSM; -.
DR   PDBsum; 6GSN; -.
DR   PDBsum; 6UZ7; -.
DR   SMR; Q6CRA3; -.
DR   STRING; 28985.XP_453536.1; -.
DR   EnsemblFungi; CAH00632; CAH00632; KLLA0_D10659g.
DR   GeneID; 2892700; -.
DR   KEGG; kla:KLLA0_D10659g; -.
DR   eggNOG; KOG3291; Eukaryota.
DR   HOGENOM; CLU_063975_0_0_1; -.
DR   InParanoid; Q6CRA3; -.
DR   OMA; DYIQIRH; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   GO; GO:0022627; C:cytosolic small ribosomal subunit; IEA:EnsemblFungi.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:EnsemblFungi.
DR   GO; GO:0006407; P:rRNA export from nucleus; IEA:EnsemblFungi.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   CDD; cd14867; uS7_Eukaryote; 1.
DR   Gene3D; 1.10.455.10; -; 1.
DR   InterPro; IPR000235; Ribosomal_S5/S7.
DR   InterPro; IPR005716; Ribosomal_S5/S7_euk/arc.
DR   InterPro; IPR020606; Ribosomal_S7_CS.
DR   InterPro; IPR023798; Ribosomal_S7_dom.
DR   InterPro; IPR036823; Ribosomal_S7_dom_sf.
DR   PANTHER; PTHR11205; PTHR11205; 1.
DR   Pfam; PF00177; Ribosomal_S7; 1.
DR   PIRSF; PIRSF002122; RPS7p_RPS7a_RPS5e_RPS7o; 1.
DR   SUPFAM; SSF47973; SSF47973; 1.
DR   TIGRFAMs; TIGR01028; uS7_euk_arch; 1.
DR   PROSITE; PS00052; RIBOSOMAL_S7; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:3J80, ECO:0007829|PDB:3J81};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000598};
KW   Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274,
KW   ECO:0000256|RuleBase:RU003619};
KW   Ribosomal protein {ECO:0000256|ARBA:ARBA00022980,
KW   ECO:0000256|RuleBase:RU003619}.
FT   DOMAIN          85..227
FT                   /note="Ribosomal_S7"
FT                   /evidence="ECO:0000259|Pfam:PF00177"
SQ   SEQUENCE   227 AA;  25351 MW;  D4731B68DE41D17C CRC64;
     MSEHEAQVEV EVQEDFEVVQ EFVPVELATT IPVEIQQAQQ EIKLFNKWSF EDVEVKDASL
     VDYIQISKPI YVAHTAGRYA NKRFRKAQCP IVERLTNSLM MNGRNNGKKL KAVRIVKHTL
     EIINVLTDQN PLQVVVDAII NSGPREDTTR VGGGGAARRQ AVDVSPLRRV NQSIALLTIG
     AREAAFRNIK TIAETLAEEL INAAKGSSTS YAIKKKDELE RVAKSNR
//
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