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Database: UniProt
Entry: Q76RH3_HHV8
LinkDB: Q76RH3_HHV8
Original site: Q76RH3_HHV8 
ID   Q76RH3_HHV8             Unreviewed;        61 AA.
AC   Q76RH3; Q2HR94;
DT   15-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   15-MAY-2007, sequence version 1.
DT   07-APR-2021, entry version 53.
DE   RecName: Full=Cytoplasmic envelopment protein 3 {ECO:0000256|HAMAP-Rule:MF_04042};
GN   Name=ORF38 {ECO:0000313|EMBL:ADQ57919.1};
GN   ORFNames=HHV8GK18_gp42 {ECO:0000313|EMBL:QGX86272.1};
OS   Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=37296 {ECO:0000313|EMBL:AAB62610.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AAB62610.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=9151804;
RA   Neipel F., Albrecht J.C., Fleckenstein B.;
RT   "Cell-homologous genes in the Kaposi's sarcoma-associated rhadinovirus
RT   human herpesvirus 8: determinants of its pathogenicity?";
RL   J. Virol. 71:4187-4192(1997).
RN   [2] {ECO:0000313|EMBL:AAB62610.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Neipel F., Albrecht J.-C., Ensser A., Huang Y.-Q., Li J.J.,
RA   Friedman-Kien A.E., Fleckenstein B.;
RT   "The genome of human herpesvirus 8 cloned from Kaposi's sarcoma.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ACY00436.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=JSC-1 {ECO:0000313|EMBL:ACY00436.1};
RA   Brulois K., Lee A., Chang H.;
RL   Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:ADQ57919.1, ECO:0000313|Proteomes:UP000146550}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSHV-BAC36 {ECO:0000313|EMBL:ADQ57919.1};
RX   PubMed=21307197; DOI=10.1128/JVI.02068-10;
RA   Yakushko Y., Hackmann C., Gunther T., Ruckert J., Henke M., Koste L.,
RA   Alkharsah K., Bohne J., Grundhoff A., Schulz T.F., Henke-Gendo C.;
RT   "Kaposi's sarcoma-associated herpesvirus bacterial artificial chromosome
RT   contains a duplication of a long unique-region fragment within the terminal
RT   repeat region.";
RL   J. Virol. 85:4612-4617(2011).
RN   [5] {ECO:0000313|EMBL:ACY00436.1, ECO:0000313|Proteomes:UP000141755}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JSC-1 {ECO:0000313|EMBL:ACY00436.1};
RX   PubMed=22740391; DOI=10.1128/JVI.01019-12;
RA   Brulois K.F., Chang H., Lee A.S., Ensser A., Wong L.Y., Toth Z., Lee S.H.,
RA   Lee H.R., Myoung J., Ganem D., Oh T.K., Kim J.F., Gao S.J., Jung J.U.;
RT   "Construction and Manipulation of a New Kaposi's Sarcoma-Associated
RT   Herpesvirus Bacterial Artificial Chromosome Clone.";
RL   J. Virol. 86:9708-9720(2012).
RN   [6] {ECO:0000313|EMBL:ALH44279.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ZM027 {ECO:0000313|EMBL:ALH44279.1}, ZM091
RC   {ECO:0000313|EMBL:ALH44367.1}, ZM095 {ECO:0000313|EMBL:ALH44455.1},
RC   ZM102 {ECO:0000313|EMBL:ALH44542.1}, ZM108
RC   {ECO:0000313|EMBL:ALH44718.1}, ZM114 {ECO:0000313|EMBL:ALH44806.1},
RC   ZM117 {ECO:0000313|EMBL:ALH44982.1}, ZM121
RC   {ECO:0000313|EMBL:ALH45156.1}, ZM128 {ECO:0000313|EMBL:ALH45420.1},
RC   and ZM130 {ECO:0000313|EMBL:ALH45506.1};
RX   PubMed=26423952; DOI=10.1128/JVI.01712-15;
RA   Olp L.N., Jeanniard A., Marimo C., West J.T., Wood C.;
RT   "Whole-Genome Sequencing of Kaposi's Sarcoma-Associated Herpesvirus from
RT   Zambian Kaposi's Sarcoma Biopsy Specimens Reveals Unique Viral Diversity.";
RL   J. Virol. 89:12299-12308(2015).
RN   [7] {ECO:0000313|EMBL:AKE33074.1, ECO:0000313|Proteomes:UP000155579}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25736227; DOI=10.1016/j.jviromet.2015.02.022;
RA   Kati S., Hage E., Mynarek M., Ganzenmueller T., Indenbirken D.,
RA   Grundhoff A., Schulz T.F.;
RT   "Generation of high-titre virus stocks using BrK.219, a B-cell line
RT   infected stably with recombinant Kaposi's sarcoma-associated herpesvirus.";
RL   J. Virol. Methods 217:79-86(2015).
RN   [8] {ECO:0000313|EMBL:BAV17889.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SPEL {ECO:0000313|EMBL:BAV17889.1};
RX   PubMed=27536332; DOI=10.1186/s13027-016-0086-5;
RA   Osawa M., Mine S., Ota S., Kato K., Sekizuka T., Kuroda M., Kataoka M.,
RA   Fukumoto H., Sato Y., Kanno T., Hasegawa H., Ueda K., Fukayama M.,
RA   Maeda T., Kanoh S., Kawana A., Fujikura Y., Katano H.;
RT   "Establishing and characterizing a new primary effusion lymphoma cell line
RT   harboring Kaposi's sarcoma-associated herpesvirus.";
RL   Infect. Agents Cancer 11:37-37(2016).
RN   [9] {ECO:0000313|EMBL:BBA90883.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Japan1 {ECO:0000313|EMBL:BBA91146.1}, Miyako1
RC   {ECO:0000313|EMBL:BBA90883.1}, Miyako2 {ECO:0000313|EMBL:BBA90970.1},
RC   and Miyako3 {ECO:0000313|EMBL:BBA91058.1};
RX   PubMed=28968717;
RA   Awazawa R., Utsumi D., Katano H., Awazawa T., Miyagi T., Hayashi K.,
RA   Matori S., Uezato H., Takahashi K.;
RT   "High Prevalence of Distinct Human Herpesvirus 8 Contributes to the High
RT   Incidence of Non-acquired Immune Deficiency Syndrome-Associated Kaposi's
RT   Sarcoma in Isolated Japanese Islands.";
RL   J. Infect. Dis. 216:850-858(2017).
RN   [10] {ECO:0000313|EMBL:QGX86272.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Beauclair G., Naimo E., Dubich T., Rueckert J., Koch S., Dhingra A.,
RA   Wirth D., Schulz T.F.;
RT   "Targeting the Kaposi Sarcoma Herpesvirus ORF 21 tyrosine kinase and viral
RT   lytic reactivation by tyrosine kinase inhibitors approved for clinical
RT   use.";
RL   J. Virol. 0:0-0(2019).
RN   [11] {ECO:0000313|EMBL:QAX88103.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=JSC-1 {ECO:0000313|EMBL:QAX88103.1};
RX   PubMed=30682185; DOI=10.1371/journal.ppat.1007489;
RA   De Leo A., Deng Z., Vladimirova O., Chen H.S., Dheekollu J., Calderon A.,
RA   Myers K.A., Hayden J., Keeney F., Kaufer B.B., Yuan Y., Robertson E.,
RA   Lieberman P.M.;
RT   "LANA oligomeric architecture is essential for KSHV nuclear body formation
RT   and viral genome maintenance during latency.";
RL   PLoS Pathog. 15:e1007489-e1007489(2019).
RN   [12] {ECO:0000313|EMBL:QFU18575.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BC1_UNC {ECO:0000313|EMBL:QFU18661.1}, UNC_KICS009
RC   {ECO:0000313|EMBL:QFU18575.1}, and UNC_KICS010
RC   {ECO:0000313|EMBL:QFU18747.1};
RA   Caro-Vegas C., Sellers S., Host K., Seltzer J., Landis J.T., Fisher W.,
RA   Damania B., Dittmer D.;
RT   "KSHV-associated inflammatory cytokine syndrome (KICS): Viral replication
RT   and IL-10 predict disease progression.";
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:QKE51232.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BC3 {ECO:0000313|EMBL:QKE51232.1}, P030_KS
RC   {ECO:0000313|EMBL:QKE51319.1}, P044_PEL {ECO:0000313|EMBL:QKE51406.1},
RC   P075_MCD {ECO:0000313|EMBL:QKE51580.1}, P076_PEL
RC   {ECO:0000313|EMBL:QKE51667.1}, P100_PEL {ECO:0000313|EMBL:QKE51754.1},
RC   and P133_MCD {ECO:0000313|EMBL:QKE51841.1};
RA   Jary A., Leducq V., Desire N., Palich R., Joly V., Canestri A.,
RA   Gothland A., Lambert-Niclot S., Surgers L., Amiel C., Descamps D.,
RA   Spano J.-P., Katlama C., Calvez V., Marcelin A.-G.;
RT   "Spread of a new Kaposi's sarcoma-associated herpesvirus variant driving
RT   severe pathologies in men who have sex with men.";
RL   Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|EMBL:QGX86272.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Goetting J., Naimo E., Schulz T.F.;
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN   [15] {ECO:0000313|EMBL:QLF96531.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FNL002 {ECO:0000313|EMBL:QLF96531.1}, FNL003
RC   {ECO:0000313|EMBL:QLF96615.1}, FNL004 {ECO:0000313|EMBL:QLF96699.1},
RC   FNL005 {ECO:0000313|EMBL:QLF96783.1}, FNL006
RC   {ECO:0000313|EMBL:QLF96867.1}, FNL007 {ECO:0000313|EMBL:QLF96952.1},
RC   FNL009 {ECO:0000313|EMBL:QLF97037.1}, and FNL011
RC   {ECO:0000313|EMBL:QLF97122.1};
RA   Cornejo Castro E.M., Marshall V., Lack J., Lurain K., Immonen T., Labo N.,
RA   Fisher N.C., Ramaswami R., Wyvill K.M., Aleman K., Polizzotto M.N., Cam M.,
RA   Keele B.F., Yarchoan R., Uldrick T.S., Whitby D.;
RT   "Dual infection and recombination of Kaposi sarcoma herpesvirus revealed by
RT   whole-genome sequence analysis of effusion samples.";
RL   Virus Evol 0:0-0(2020).
RN   [16] {ECO:0000313|EMBL:QLI55781.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=U004-C {ECO:0000313|EMBL:QLI55781.1}, U004-D
RC   {ECO:0000313|EMBL:QLI55959.1}, U004-o1 {ECO:0000313|EMBL:QLI55870.1},
RC   U020-B {ECO:0000313|EMBL:QLI56048.1}, U020-C
RC   {ECO:0000313|EMBL:QLI56137.1}, U020-o1 {ECO:0000313|EMBL:QLI56226.1},
RC   and U023-o1 {ECO:0000313|EMBL:QLI56315.1};
RA   Santiago J.C.A.;
RL   Submitted (MAY-2020) to the EMBL/GenBank/DDBJ databases.
RN   [17] {ECO:0000313|EMBL:QLI55781.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=U004-C {ECO:0000313|EMBL:QLI55781.1}, U004-D
RC   {ECO:0000313|EMBL:QLI55959.1}, U004-o1 {ECO:0000313|EMBL:QLI55870.1},
RC   U020-B {ECO:0000313|EMBL:QLI56048.1}, U020-C
RC   {ECO:0000313|EMBL:QLI56137.1}, U020-o1 {ECO:0000313|EMBL:QLI56226.1},
RC   and U023-o1 {ECO:0000313|EMBL:QLI56315.1};
RA   Goldman J.D., Zhao H., Pankow A.P., Okuku F., Schmitt M.W., Chen L.H.,
RA   Hill C.A., Casper C., Phipps W.T., Mullins J.I.;
RT   "Tumor-specific changes in Kaposi sarcoma-associated herpesvirus genomes in
RT   Ugandan adults with Kaposi sarcoma.";
RL   Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the cytoplasmic envelopment of
CC       tegument proteins and capsids during the assembly and egress processes.
CC       Participates also in viral entry at the fusion step probably by
CC       regulating the core fusion machinery. {ECO:0000256|HAMAP-
CC       Rule:MF_04042}.
CC   -!- SUBUNIT: Interacts with cytoplasmic envelopment protein 2; this
CC       interaction is essential for the proper localization of each protein to
CC       the assembly complex and thus for the production of infectious virus.
CC       {ECO:0000256|HAMAP-Rule:MF_04042}.
CC   -!- INTERACTION:
CC       Q76RH3; P50897: PPT1; Xeno; NbExp=2; IntAct=EBI-14033513, EBI-1237011;
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000256|HAMAP-
CC       Rule:MF_04042}. Virion membrane {ECO:0000256|HAMAP-Rule:MF_04042};
CC       Lipid-anchor {ECO:0000256|HAMAP-Rule:MF_04042}. Host cell membrane
CC       {ECO:0000256|HAMAP-Rule:MF_04042}; Lipid-anchor {ECO:0000256|HAMAP-
CC       Rule:MF_04042}; Cytoplasmic side {ECO:0000256|HAMAP-Rule:MF_04042}.
CC       Host Golgi apparatus membrane {ECO:0000256|HAMAP-Rule:MF_04042}; Lipid-
CC       anchor {ECO:0000256|HAMAP-Rule:MF_04042}; Cytoplasmic side
CC       {ECO:0000256|HAMAP-Rule:MF_04042}. Note=Virion membrane-associated
CC       tegument protein. Associates with host membrane lipids rafts. During
CC       virion morphogenesis, this protein probably accumulates in the
CC       endosomes and trans-Golgi where secondary envelopment occurs. It is
CC       probably transported to the cell surface from where it is endocytosed
CC       and directed to the trans-Golgi network (TGN). {ECO:0000256|HAMAP-
CC       Rule:MF_04042}.
CC   -!- PTM: Myristoylation and palmitoylation (probably on one or more of the
CC       nearby cysteines at the N-terminus) enable membrane-binding and Golgi
CC       apparatus-specific targeting and are essential for efficient packaging.
CC       {ECO:0000256|HAMAP-Rule:MF_04042}.
CC   -!- PTM: Phosphorylated. Phosphorylation does not seem to be required for
CC       recycling to the host Golgi apparatus. Packaging is selective for
CC       underphosphorylated forms. {ECO:0000256|HAMAP-Rule:MF_04042}.
CC   -!- SIMILARITY: Belongs to the herpesviridae cytoplasmic envelopment
CC       protein 3 family. {ECO:0000256|HAMAP-Rule:MF_04042}.
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DR   EMBL; U93872; AAB62610.1; -; Genomic_DNA.
DR   EMBL; GQ994935; ACY00436.1; -; Genomic_DNA.
DR   EMBL; HQ404500; ADQ57919.1; -; Genomic_DNA.
DR   EMBL; KF588566; AKE33074.1; -; Genomic_DNA.
DR   EMBL; KT271454; ALH44279.1; -; Genomic_DNA.
DR   EMBL; KT271455; ALH44367.1; -; Genomic_DNA.
DR   EMBL; KT271456; ALH44455.1; -; Genomic_DNA.
DR   EMBL; KT271457; ALH44542.1; -; Genomic_DNA.
DR   EMBL; KT271459; ALH44718.1; -; Genomic_DNA.
DR   EMBL; KT271460; ALH44806.1; -; Genomic_DNA.
DR   EMBL; KT271462; ALH44982.1; -; Genomic_DNA.
DR   EMBL; KT271464; ALH45156.1; -; Genomic_DNA.
DR   EMBL; KT271467; ALH45420.1; -; Genomic_DNA.
DR   EMBL; KT271468; ALH45506.1; -; Genomic_DNA.
DR   EMBL; AP017458; BAV17889.1; -; Genomic_DNA.
DR   EMBL; LC200586; BBA90883.1; -; Genomic_DNA.
DR   EMBL; LC200587; BBA90970.1; -; Genomic_DNA.
DR   EMBL; LC200588; BBA91058.1; -; Genomic_DNA.
DR   EMBL; LC200589; BBA91146.1; -; Genomic_DNA.
DR   EMBL; MK143395; QAX88103.1; -; Genomic_DNA.
DR   EMBL; MK733606; QFU18575.1; -; Genomic_DNA.
DR   EMBL; MK733607; QFU18661.1; -; Genomic_DNA.
DR   EMBL; MK733608; QFU18747.1; -; Genomic_DNA.
DR   EMBL; MK733609; QFU18833.1; -; Genomic_DNA.
DR   EMBL; MN752405; QGX86272.1; -; Genomic_DNA.
DR   EMBL; MK876731; QKE51232.1; -; Genomic_DNA.
DR   EMBL; MK876732; QKE51319.1; -; Genomic_DNA.
DR   EMBL; MK876733; QKE51406.1; -; Genomic_DNA.
DR   EMBL; MK876735; QKE51580.1; -; Genomic_DNA.
DR   EMBL; MK876736; QKE51667.1; -; Genomic_DNA.
DR   EMBL; MK876737; QKE51754.1; -; Genomic_DNA.
DR   EMBL; MK876738; QKE51841.1; -; Genomic_DNA.
DR   EMBL; MN419219; QLF96531.1; -; Genomic_DNA.
DR   EMBL; MN419220; QLF96615.1; -; Genomic_DNA.
DR   EMBL; MN419221; QLF96699.1; -; Genomic_DNA.
DR   EMBL; MN419222; QLF96783.1; -; Genomic_DNA.
DR   EMBL; MN419223; QLF96867.1; -; Genomic_DNA.
DR   EMBL; MN419224; QLF96952.1; -; Genomic_DNA.
DR   EMBL; MN419225; QLF97037.1; -; Genomic_DNA.
DR   EMBL; MN419226; QLF97122.1; -; Genomic_DNA.
DR   EMBL; MT510663; QLI55781.1; -; Genomic_DNA.
DR   EMBL; MT510664; QLI55870.1; -; Genomic_DNA.
DR   EMBL; MT510665; QLI55959.1; -; Genomic_DNA.
DR   EMBL; MT510666; QLI56048.1; -; Genomic_DNA.
DR   EMBL; MT510667; QLI56137.1; -; Genomic_DNA.
DR   EMBL; MT510668; QLI56226.1; -; Genomic_DNA.
DR   EMBL; MT510669; QLI56315.1; -; Genomic_DNA.
DR   RefSeq; YP_001129391.1; NC_009333.1.
DR   IntAct; Q76RH3; 6.
DR   DNASU; 4961435; -.
DR   GeneID; 4961435; -.
DR   KEGG; vg:4961435; -.
DR   Proteomes; UP000141755; Genome.
DR   Proteomes; UP000146550; Genome.
DR   Proteomes; UP000155579; Genome.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046760; P:viral budding from Golgi membrane; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04042; HSV_CEP3_gammahv; 1.
DR   InterPro; IPR024360; Herpesvirus_UL11_homo.
DR   Pfam; PF10813; DUF2733; 1.
PE   1: Evidence at protein level;
KW   Host cell membrane {ECO:0000256|HAMAP-Rule:MF_04042};
KW   Host Golgi apparatus {ECO:0000256|ARBA:ARBA00022812, ECO:0000256|HAMAP-
KW   Rule:MF_04042}; Host membrane {ECO:0000256|HAMAP-Rule:MF_04042};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288, ECO:0000256|HAMAP-
KW   Rule:MF_04042};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_04042};
KW   Myristate {ECO:0000256|ARBA:ARBA00022707, ECO:0000256|HAMAP-Rule:MF_04042};
KW   Palmitate {ECO:0000256|ARBA:ARBA00023139, ECO:0000256|HAMAP-Rule:MF_04042};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|HAMAP-
KW   Rule:MF_04042}; Reference proteome {ECO:0000313|Proteomes:UP000141755};
KW   Virion {ECO:0000256|ARBA:ARBA00022844, ECO:0000256|HAMAP-Rule:MF_04042};
KW   Virion tegument {ECO:0000256|ARBA:ARBA00022580, ECO:0000256|HAMAP-
KW   Rule:MF_04042}.
FT   INIT_MET        1
FT                   /note="Removed; by host"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_04042"
FT   LIPID           2
FT                   /note="N-myristoyl glycine; by host"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_04042"
SQ   SEQUENCE   61 AA;  6893 MW;  78AB187E8CC6DF7D CRC64;
     MGFLLSICKR PSQPVDVDGE PLDVVVDYDP IRVSEKGMLL EQSQSPYPAL KKKKKNKEAI
     Y
//
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