ID R0KFU8_EXST2 Unreviewed; 641 AA.
AC R0KFU8;
DT 26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 1.
DT 04-NOV-2026, entry version 42.
DE RecName: Full=Cation/H+ exchanger transmembrane domain-containing protein {ECO:0000259|Pfam:PF00999};
GN ORFNames=SETTUDRAFT_170521 {ECO:0000313|EMBL:EOA91698.1};
OS Exserohilum turcicum (strain 28A) (Northern leaf blight fungus)
OS (Setosphaeria turcica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae;
OC Exserohilum.
OX NCBI_TaxID=671987 {ECO:0000313|EMBL:EOA91698.1, ECO:0000313|Proteomes:UP000016935};
RN [1] {ECO:0000313|EMBL:EOA91698.1, ECO:0000313|Proteomes:UP000016935}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=28A {ECO:0000313|Proteomes:UP000016935};
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
RN [2] {ECO:0000313|EMBL:EOA91698.1, ECO:0000313|Proteomes:UP000016935}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=28A {ECO:0000313|Proteomes:UP000016935};
RX PubMed=23357949; DOI=10.1371/journal.pgen.1003233;
RA Condon B.J., Leng Y., Wu D., Bushley K.E., Ohm R.A., Otillar R., Martin J.,
RA Schackwitz W., Grimwood J., MohdZainudin N., Xue C., Wang R., Manning V.A.,
RA Dhillon B., Tu Z.J., Steffenson B.J., Salamov A., Sun H., Lowry S.,
RA LaButti K., Han J., Copeland A., Lindquist E., Barry K., Schmutz J.,
RA Baker S.E., Ciuffetti L.M., Grigoriev I.V., Zhong S., Turgeon B.G.;
RT "Comparative genome structure, secondary metabolite, and effector coding
RT capacity across Cochliobolus pathogens.";
RL PLoS Genet. 9:E1003233-E1003233(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KB908481; EOA91698.1; -; Genomic_DNA.
DR RefSeq; XP_008020798.1; XM_008022607.1.
DR AlphaFoldDB; R0KFU8; -.
DR STRING; 671987.R0KFU8; -.
DR GeneID; 19401046; -.
DR eggNOG; KOG3319; Eukaryota.
DR eggNOG; KOG4505; Eukaryota.
DR HOGENOM; CLU_008635_5_0_1; -.
DR OrthoDB; 2190219at2759; -.
DR Proteomes; UP000016935; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0030007; P:intracellular potassium ion homeostasis; IEA:TreeGrafter.
DR GO; GO:0120029; P:proton export across plasma membrane; IEA:InterPro.
DR GO; GO:0042391; P:regulation of membrane potential; IEA:InterPro.
DR GO; GO:0036376; P:sodium ion export across plasma membrane; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger_TM.
DR InterPro; IPR004712; Na+/H+_antiporter_fungi.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR007203; ORMDL.
DR PANTHER; PTHR31382:SF2; CATION_H+ EXCHANGER DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR31382; NA(+)/H(+) ANTIPORTER; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF04061; ORMDL; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000016935};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 47..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 149..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 242..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 413..440
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 493..515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 576..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 192..596
FT /note="Cation/H+ exchanger transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT REGION 619..641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..641
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 641 AA; 71401 MW; 90438FFEBE1DEB34 CRC64;
MSLDPAKDAR RRRSSSLVYK EPPESLEQLS DQSALPNLNV EWVNAKGAWA IHFVLIFFGK
ILFDIIPGMS QEASWTLVNL SYVAGSYLMF HYVRGVPFDF NSGAYDNLNM WEQIDNGDQY
TPAKKFLLSV PILLFLVSTH YTNYDLTYFL INCFATIAVV IPKLPSFIMV WSQLEPTGPH
VTYVALTFFL ILYALFSVLI RNRLHLSEPP LATLFGIIVG PRALGLLRPY EWGFSDDLIQ
ETTRLIVGIQ CFAVGLELED RYLSKKAYAL LALLGPVMTF GWLICAFFIT FIFQTDFVTA
MTIAACLTPT DPVLAASVLS NSQFSTRVPK RIRDLLSAES GCNDGVSFPF LYIGLSLLLK
NTAGSVLKKW FLVTVLYQCV VGVIVGIVLG HVFNMLYRIS HAREWMGRPA YLTFYLLAAI
FSVGLAAVLG VDDFLVAFFA GRGFSHRQRS PLAETALPVI IDMMINSAFF IFFGAMIPWD
SFNKLDAITP GRLVGLLVLI LLFRRIPIVF SLFQLKLLPF VKTKTEALFV GHFGPMGVGA
LFLAIEARAQ LETGTSLPLP SPPDDLPIEK QRTVTLIWPI VCFIVLGSTM VHGFSTLAVS
IGGHFARKEA ERAPLIGGES EGLHGMIHDE EEDTEVEDNY E
//
