ID RL24A_CANAL Reviewed; 155 AA.
AC Q5A6A1;
DT 12-OCT-2022, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 10-JUN-2026, entry version 119.
DE RecName: Full=Large ribosomal subunit protein eL24 {ECO:0000303|PubMed:35613268};
DE AltName: Full=60S ribosomal protein L24-A;
GN Name=RPL24A {ECO:0000303|PubMed:35613268}; Synonyms=RPL24;
GN OrderedLocusNames=orf19.3789; ORFNames=CAALFM_C404890CA;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Pichiomycetes;
OC Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4] {ECO:0007744|PDB:7PZY, ECO:0007744|PDB:7Q0F, ECO:0007744|PDB:7Q0P}
RP STRUCTURE BY ELECTRON MICROSCOPY (2.32 ANGSTROMS) OF THE 80S RIBOSOME, AND
RP SUBUNIT.
RX PubMed=35613268; DOI=10.1126/sciadv.abn1062;
RA Zgadzay Y., Kolosova O., Stetsenko A., Wu C., Bruchlen D., Usachev K.,
RA Validov S., Jenner L., Rogachev A., Yusupova G., Sachs M.S., Guskov A.,
RA Yusupov M.;
RT "E-site drug specificity of the human pathogen Candida albicans ribosome.";
RL Sci. Adv. 8:eabn1062-eabn1062(2022).
CC -!- FUNCTION: Component of the ribosome, a large ribonucleoprotein complex
CC responsible for the synthesis of proteins in the cell. The small
CC ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the
CC encoded message by selecting cognate aminoacyl-transfer RNA (tRNA)
CC molecules. The large subunit (LSU) contains the ribosomal catalytic
CC site termed the peptidyl transferase center (PTC), which catalyzes the
CC formation of peptide bonds, thereby polymerizing the amino acids
CC delivered by tRNAs into a polypeptide chain. The nascent polypeptides
CC leave the ribosome through a tunnel in the LSU and interact with
CC protein factors that function in enzymatic processing, targeting, and
CC the membrane insertion of nascent chains at the exit of the ribosomal
CC tunnel. {ECO:0000305|PubMed:35613268}.
CC -!- SUBUNIT: Component of the large ribosomal subunit (PubMed:35613268).
CC Mature ribosomes consist of a small (40S) and a large (60S) subunit
CC (PubMed:35613268). The 40S subunit contains about 32 different proteins
CC and 1 molecule of RNA (18S) (PubMed:35613268). The 60S subunit contains
CC 45 different proteins and 3 molecules of RNA (25S, 5.8S and 5S)
CC (PubMed:35613268). {ECO:0000269|PubMed:35613268}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:35613268}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL24 family.
CC {ECO:0000305}.
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DR EMBL; CP017626; AOW29232.1; -; Genomic_DNA.
DR RefSeq; XP_717194.1; XM_712101.2.
DR PDB; 7PZY; EM; 2.32 A; 7=1-155.
DR PDB; 7Q08; EM; 2.56 A; 7=1-155.
DR PDB; 7Q0F; EM; 2.64 A; 7=1-155.
DR PDB; 7Q0P; EM; 2.77 A; 7=1-155.
DR PDB; 7Q0R; EM; 2.67 A; 7=1-155.
DR PDB; 8C3A; X-ray; 3.00 A; 7/BR=1-155.
DR PDB; 8OGJ; EM; 3.10 A; 7=1-155.
DR PDB; 8OH6; X-ray; 3.35 A; 7/BR=1-155.
DR PDB; 8OI5; X-ray; 2.90 A; 7/BR=1-155.
DR PDB; 8OJ3; X-ray; 3.50 A; 7/BR=1-155.
DR PDB; 9G1Z; EM; 3.10 A; 7=1-155.
DR PDB; 9G30; EM; 2.35 A; 7=1-155.
DR PDB; 9G6J; EM; 2.15 A; 7=1-155.
DR PDBsum; 7PZY; -.
DR PDBsum; 7Q08; -.
DR PDBsum; 7Q0F; -.
DR PDBsum; 7Q0P; -.
DR PDBsum; 7Q0R; -.
DR PDBsum; 8C3A; -.
DR PDBsum; 8OGJ; -.
DR PDBsum; 8OH6; -.
DR PDBsum; 8OI5; -.
DR PDBsum; 8OJ3; -.
DR PDBsum; 9G1Z; -.
DR PDBsum; 9G30; -.
DR PDBsum; 9G6J; -.
DR AlphaFoldDB; Q5A6A1; -.
DR EMDB; EMD-50957; -.
DR EMDB; EMD-51103; -.
DR SMR; Q5A6A1; -.
DR FunCoup; Q5A6A1; 941.
DR STRING; 237561.Q5A6A1; -.
DR PaxDb; 237561-Q5A6A1; -.
DR EnsemblFungi; C4_04890C_A-T; C4_04890C_A-T-p1; C4_04890C_A.
DR GeneID; 3641174; -.
DR KEGG; cal:CAALFM_C404890CA; -.
DR CGD; CAL0000190222; RPL24A.
DR VEuPathDB; FungiDB:C4_04890C_A; -.
DR eggNOG; KOG1722; Eukaryota.
DR HOGENOM; CLU_106411_0_0_1; -.
DR InParanoid; Q5A6A1; -.
DR OMA; PGHGKKM; -.
DR OrthoDB; 1727108at2759; -.
DR Proteomes; UP000000559; Chromosome 4.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR GO; GO:0006414; P:translational elongation; IEA:UniProtKB-ARBA.
DR CDD; cd00472; Ribosomal_L24e_L24; 1.
DR FunFam; 2.30.170.20:FF:000002; 60S ribosomal protein L24; 1.
DR Gene3D; 6.10.10.140; -; 1.
DR Gene3D; 2.30.170.20; Ribosomal protein L24e; 1.
DR InterPro; IPR038630; L24e/L24_sf.
DR InterPro; IPR056366; Ribosomal_eL24.
DR InterPro; IPR000988; Ribosomal_eL24-rel_N.
DR InterPro; IPR023442; Ribosomal_eL24_CS.
DR PANTHER; PTHR10792; 60S RIBOSOMAL PROTEIN L24; 1.
DR PANTHER; PTHR10792:SF1; RIBOSOMAL PROTEIN L24; 1.
DR Pfam; PF01246; Ribosomal_L24e; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR PROSITE; PS01073; RIBOSOMAL_L24E; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein.
FT CHAIN 1..155
FT /note="Large ribosomal subunit protein eL24"
FT /id="PRO_0000456513"
FT REGION 87..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..143
FT /note="Low complexity"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT TURN 7..9
FT /evidence="ECO:0007829|PDB:9G6J"
FT STRAND 18..22
FT /evidence="ECO:0007829|PDB:9G6J"
FT STRAND 28..33
FT /evidence="ECO:0007829|PDB:9G6J"
FT HELIX 34..41
FT /evidence="ECO:0007829|PDB:9G6J"
FT HELIX 46..48
FT /evidence="ECO:0007829|PDB:9G6J"
FT HELIX 53..58
FT /evidence="ECO:0007829|PDB:9G6J"
FT TURN 59..62
FT /evidence="ECO:0007829|PDB:8OJ3"
FT HELIX 87..93
FT /evidence="ECO:0007829|PDB:8OI5"
FT HELIX 98..124
FT /evidence="ECO:0007829|PDB:8OI5"
SQ SEQUENCE 155 AA; 17383 MW; 4DE8E09C953C5484 CRC64;
MKIEVDSFSG SKIYPGRGTL FVRGDSKIFR FQSSKSASLF QQRKNPRRIS WTVLYRRHHK
KGISEEAAKK RTRKTVKHQR AIVGASLELI KERRSQKPSD RKAARDSKLA KDKEAKKAAK
AARKAEKAKA VASGASVVSK QQAKGSFQKV KATSR
//
