ID RLP24_DROME Reviewed; 191 AA.
AC Q9VGN9;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 28-JAN-2026, entry version 147.
DE RecName: Full=Probable ribosome biogenesis protein RLP24;
GN Name=RpL24-like; ORFNames=CG6764;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Testis;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-136, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit.
CC Ensures the docking of NOG1 to pre-60S particles (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Associated with nucleolar and cytoplasmic pre-60S particles.
CC At the end of biogenesis it dissociates from cytoplasmic pre-60S
CC particles and is likely to be exchanged for its ribosomal homologue,
CC RPL24 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL24 family.
CC {ECO:0000305}.
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DR EMBL; AE014297; AAF54637.1; -; Genomic_DNA.
DR EMBL; AY113325; AAM29330.1; -; mRNA.
DR RefSeq; NP_650073.1; NM_141816.4.
DR AlphaFoldDB; Q9VGN9; -.
DR SMR; Q9VGN9; -.
DR BioGRID; 66505; 9.
DR FunCoup; Q9VGN9; 1747.
DR IntAct; Q9VGN9; 43.
DR STRING; 7227.FBpp0081879; -.
DR iPTMnet; Q9VGN9; -.
DR PaxDb; 7227-FBpp0081879; -.
DR DNASU; 41372; -.
DR EnsemblMetazoa; FBtr0082403; FBpp0081879; FBgn0037899.
DR GeneID; 41372; -.
DR KEGG; dme:Dmel_CG6764; -.
DR UCSC; CG6764-RA; d. melanogaster.
DR AGR; FB:FBgn0037899; -.
DR CTD; 41372; -.
DR FlyBase; FBgn0037899; RpL24-like.
DR VEuPathDB; VectorBase:FBgn0037899; -.
DR eggNOG; KOG1723; Eukaryota.
DR HOGENOM; CLU_089419_1_1_1; -.
DR InParanoid; Q9VGN9; -.
DR OMA; TCYFCSG; -.
DR OrthoDB; 10262490at2759; -.
DR PhylomeDB; Q9VGN9; -.
DR BioGRID-ORCS; 41372; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 41372; -.
DR PRO; PR:Q9VGN9; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0037899; Expressed in adult enteroendocrine precursor cell in adult midgut (Drosophila) and 271 other cell types or tissues.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; TAS:FlyBase.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; TAS:FlyBase.
DR GO; GO:0002181; P:cytoplasmic translation; TAS:FlyBase.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR CDD; cd00472; Ribosomal_L24e_L24; 1.
DR FunFam; 2.30.170.20:FF:000001; probable ribosome biogenesis protein RLP24; 1.
DR Gene3D; 2.30.170.20; Ribosomal protein L24e; 1.
DR InterPro; IPR038630; L24e/L24_sf.
DR InterPro; IPR056366; Ribosomal_eL24.
DR InterPro; IPR000988; Ribosomal_eL24-rel_N.
DR InterPro; IPR023442; Ribosomal_eL24_CS.
DR InterPro; IPR011017; TRASH_dom.
DR PANTHER; PTHR10792; 60S RIBOSOMAL PROTEIN L24; 1.
DR PANTHER; PTHR10792:SF8; RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED; 1.
DR Pfam; PF01246; Ribosomal_L24e; 1.
DR SMART; SM00746; TRASH; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR PROSITE; PS01073; RIBOSOMAL_L24E; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome; Ribosome biogenesis.
FT CHAIN 1..191
FT /note="Probable ribosome biogenesis protein RLP24"
FT /id="PRO_0000136902"
FT MOD_RES 136
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
SQ SEQUENCE 191 AA; 22436 MW; 21644770E407A700 CRC64;
MRIQTCYFCS SKIYPGHGVQ FVRNDCKVFK FCRGKCHKAF KRKKNPRKVG WTKAYRKAAG
KELAIDPSFE FEKRRNVPMK YSRETWQKGL EAIKRVTEIK EKRTSHFVME RLRKGRQVEI
QMDVKDVQRN MSLIRSPAAG LKQRRAQEAA EEAALMEEDL PEEKITYVDA RELEKKLEEG
MGVEDLEMLE A
//
