ID   S2JBW0_MUCC1            Unreviewed;       259 AA.
AC   S2JBW0;
DT   18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT   18-SEP-2013, sequence version 1.
DT   28-JAN-2026, entry version 43.
DE   RecName: Full=phosphoethanolamine N-methyltransferase {ECO:0000256|ARBA:ARBA00035674};
DE            EC=2.1.1.103 {ECO:0000256|ARBA:ARBA00035674};
GN   ORFNames=HMPREF1544_05401 {ECO:0000313|EMBL:EPB87741.1};
OS   Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis
OS   agent) (Calyptromyces circinelloides).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX   NCBI_TaxID=1220926 {ECO:0000313|EMBL:EPB87741.1, ECO:0000313|Proteomes:UP000014254};
RN   [1] {ECO:0000313|Proteomes:UP000014254}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1006PhL {ECO:0000313|Proteomes:UP000014254};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., Earl A., Findley K., Lee S.C., Walker B., Young S., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome sequence of Mucor circinelloides f. circinelloides 1006PhL.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N,N-dimethylethanolamine phosphate + S-adenosyl-L-methionine =
CC         phosphocholine + S-adenosyl-L-homocysteine + H(+);
CC         Xref=Rhea:RHEA:25325, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:58641, ChEBI:CHEBI:59789, ChEBI:CHEBI:295975;
CC         EC=2.1.1.103; Evidence={ECO:0000256|ARBA:ARBA00047619};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25326;
CC         Evidence={ECO:0000256|ARBA:ARBA00047619};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-methylethanolamine phosphate + S-adenosyl-L-methionine =
CC         N,N-dimethylethanolamine phosphate + S-adenosyl-L-homocysteine +
CC         H(+); Xref=Rhea:RHEA:25321, ChEBI:CHEBI:15378, ChEBI:CHEBI:57781,
CC         ChEBI:CHEBI:57856, ChEBI:CHEBI:58641, ChEBI:CHEBI:59789;
CC         EC=2.1.1.103; Evidence={ECO:0000256|ARBA:ARBA00047841};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25322;
CC         Evidence={ECO:0000256|ARBA:ARBA00047841};
CC   -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC   -!- PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004969}.
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DR   EMBL; KE123962; EPB87741.1; -; Genomic_DNA.
DR   AlphaFoldDB; S2JBW0; -.
DR   STRING; 1220926.S2JBW0; -.
DR   VEuPathDB; FungiDB:HMPREF1544_05401; -.
DR   eggNOG; ENOG502S5S2; Eukaryota.
DR   InParanoid; S2JBW0; -.
DR   OMA; IPQENYY; -.
DR   OrthoDB; 61390at2759; -.
DR   Proteomes; UP000014254; Unassembled WGS sequence.
DR   GO; GO:0000234; F:phosphoethanolamine N-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR44307; PHOSPHOETHANOLAMINE METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR44307:SF2; PHOSPHOETHANOLAMINE METHYLTRANSFERASE ISOFORM X1; 1.
DR   Pfam; PF02353; CMAS; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014254};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ   SEQUENCE   259 AA;  29367 MW;  4F9633C0D536E9D8 CRC64;
     MGLWNRDDMS FPEACENLVH AVANKMSIKP NASVLDVGFG CGDSCLLLAE HYKSKVTGIT
     NELSQWKIAN ERLTGSHLKQ NITLLHGSAD NLDQMLPSKD RFDYITSIDS AYHYNTRWKF
     LENAFKRLNL HGSIGLYDLA IEADFLDKAS PMQKSVFRFI CDTVHIPIQN LVTVEEYGDR
     LEDIGYEEVQ IEQLDRHLVF GGLSRSFDQQ YTTAMKYGIG VSLSNRIFLK VSSFLFGLLG
     SKPWLVPIIV RGVKQHEED
//