ID S4RY73_PETMA Unreviewed; 788 AA.
AC S4RY73;
DT 18-SEP-2013, integrated into UniProtKB/TrEMBL.
DT 18-SEP-2013, sequence version 1.
DT 18-JUN-2025, entry version 69.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
OS Petromyzon marinus (Sea lamprey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
OX NCBI_TaxID=7757 {ECO:0000313|Ensembl:ENSPMAP00000010164.1};
RN [1] {ECO:0000313|Ensembl:ENSPMAP00000010164.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2025) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC -!- SIMILARITY: Belongs to the RBR family. Ariadne subfamily.
CC {ECO:0000256|ARBA:ARBA00005884}.
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DR AlphaFoldDB; S4RY73; -.
DR STRING; 7757.ENSPMAP00000010164; -.
DR Ensembl; ENSPMAT00000010209.1; ENSPMAP00000010164.1; ENSPMAG00000009240.1.
DR GeneTree; ENSGT00940000165758; -.
DR HOGENOM; CLU_009823_1_0_1; -.
DR OMA; GPMEDPW; -.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd20346; BRcat_RBR_ANKIB1; 1.
DR CDD; cd20361; Rcat_RBR_ANKIB1; 1.
DR FunFam; 1.20.120.1750:FF:000003; RBR-type E3 ubiquitin transferase; 1.
DR FunFam; 1.25.40.20:FF:000040; RBR-type E3 ubiquitin transferase; 1.
DR FunFam; 3.30.40.10:FF:000019; RBR-type E3 ubiquitin transferase; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR045840; Ariadne.
DR InterPro; IPR048962; ARIH1-like_UBL.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR047564; Rcat_RBR_ANKIB1.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR027370; Znf-RING_euk.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF19422; Ariadne; 1.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF22191; IBR_1; 1.
DR Pfam; PF21235; UBA_ARI1; 1.
DR Pfam; PF13445; zf-RING_UBOX; 1.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00647; IBR; 2.
DR SMART; SM00184; RING; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT REPEAT 137..169
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 324..559
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 328..373
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 276..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 750..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..310
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 778..788
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 788 AA; 89293 MW; B81B9C2ACC97F6CD CRC64;
MGSASTKFRK ALQAGDEGLA LQLYYTNVPL AQQLDPNASY GEAYDNNTAM HYATRHAMPR
LLSVFLREKE GNPNKRNGLE ETALHCACTP LAVLIVPPSG QQEERRLLCL RMLLDWQGPL
LGPQQRERAK VDARDHHGNT PLHYAACSGM KRCVELLVVR GASLFVENED GATPCDRAEI
NRHYEVALHL ESRMVLAQDY PDGDGDEPQE PLASGCREPF EGLRAQELRE LKDLLIVETA
DMLQVPLFTA EALLRSHGWD RERLLEAWML NSDECCQRSG VQPPPPPPTG QNSWGTIPDS
RPPLRSPITP PGDLRHGLST VGARESLCEI CLGRMPESDP VDVPCGHLFC KKCWEEYLNM
KIQEGKAHSI LCPAYDCYSL VPIETIEVLV CREMARRYLQ FDIKAFVDTN PSIRWCPVPR
CEQAVRLALP GAAGGSAARA HTPTAVDCGS GHTFCWECLG EAHEPCDCGT WKQWLQKIVD
MKPEELSGVS VAAEDAANCL WLISNSKPCP SCKSPIQKND GCNHMQCTKC KHDFCWICLE
EWKKHSSSTG GYYRCTRYEV IQAVEDSSRD VANEAEKKHK KFQELDRFMH YYSRFKNHEH
SYKLELPLLQ TARAKMEILR SALENMEGVD TSFIEHAVQE LLKTRRVLRG SYGYGYFLEP
HSTQKDIFEL MQMDLEMLTE DLAQKVNRPY LRTPRQKIVR AARLAQQKRQ EFLASVARGV
APPDSPPSSR RQLVGRPWEW EFLGFSSPEE YEEVLERRRR RSRRGDPRSS HSHLTDPGLR
EESSTGRP
//
